Benzodiazepines are bicyclic heterocycles having medicinal importance. As a result several greener procedures have been developed using mild conditions and recyclable catalysts, easy work up good yields, multi component reactions less wastage and solvent less synthesis. Deepali Mahajan | Abhishek Raina "Synthesis of 1,5- Benzodiazepines: A Review" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5 , August 2021, URL: https://www.ijtsrd.com/papers/ijtsrd43842.pdf Paper URL: https://www.ijtsrd.com/chemistry/other/43842/synthesis-of-15-benzodiazepines-a-review/deepali-mahajan
International Journal of Trend in Scientific Research and Development (IJTSRD)
Volume 5 Issue 5, July-August 2021 Available Online: www.ijtsrd.com e-ISSN: 2456 – 6470
@ IJTSRD | Unique Paper ID – IJTSRD43842 | Volume – 5 | Issue – 5 | Jul-Aug 2021
Page 497
Synthesis of 1,5- Benzodiazepines: A Review
Deepali Mahajan
1
, Abhishek Raina
2
1Department of Chemistry GGM Science College, Cluster University of Jammu, Jammu And Kashmir, India
2Department of Chemistry School of Sciences, Cluster University of Jammu, Jammu And Kashmir, India
ABSTRACT
Benzodiazepines are bicyclic heterocycles having medicinal
importance. As a result several greener procedures have been
developed using mild conditions and recyclable catalysts, easy work
up good yields, multi component reactions less wastage and solvent
less synthesis.
KEYWORDS: 1,5- benzodiazepines. o-phenylenediamine, ketones
How to cite this paper: Deepali Mahajan
| Abhishek Raina "Synthesis of 1,5-
Benzodiazepines: A
Review" Published
in
International
Journal of Trend in
Scientific Research
and Development
(ijtsrd), ISSN: 2456-
6470, Volume-5 |
Issue-5, August 2021, pp.497-509, URL:
www.ijtsrd.com/papers/ijtsrd43842.pdf
Copyright © 2021 by author (s) and
International Journal of Trend in
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INTRODUCTION
The benzodiazepines1 are bicyclic heterocycles; benzene nucleus being fused to a seven membered hetero ring
having two nitrogen atoms. The benzodiazepines are a class of drugs with hypnotic, anxiolytic, anticonvulsant,
amnestic and muscle relaxant properties. They serve as cholecystokinin A and B antagonists, opioid receptor
ligands, platelet-activating factor antagonists, HIV inhibitors, farnesyltransferase inhibitors and as somatoform
disorder.
Synthesi