Acta Dermatoven APA Vol 18, 2009, No 3
C l i n i c a l s t u d y
Association of cytokine gene polymorphisms with psoriasis
Background: Psoriasis is a chronic inflammatory skin disease with an immunogenetic background.
This study was planned to check for the association of polymorphisms related to cytokine genes
TNF-α−308(G/A), IL-10−1082(G/A), IL-6−174(G/C), and IL-1Ra (VNTR) with psoriasis in cases from Egypt.
Methods: This study included 46 cases with psoriasis recruited from the Department of Dermatol-
ogy, University Hospitals, Nile Delta region of Egypt. They included 14 males and 32 females with
a mean age ± SD of 46.68 ± 12.16 years and a range of 15 to 70 years. Their genotypes were com-
pared to 98 healthy controls of matched age and sex from the same locality. Genotyping was done
through DNA amplification using PCR with sequence-specific primers for polymorphic alleles.
Results: Compared to controls, cases showed a significantly higher frequency of certain geno-
types including IL-6−174 CC (p < 0.001, OR = 6.7), IL-10−1082 GG (p < 0.05, OR = 5.1), and TNF-α−308
GG (p < 0.05, OR = 3.7). Combined heterozygosity for IL-10 GA, IL-6 GC, and TNF GA showed a
significant low frequency among the cases studied.
Conclusion: Genetic polymorphisms related to the IL6, IL10, and TNF-α genes showed a particular
pattern of association with psoriasis that may have a potential impact on disease counseling and
Association of cytokine gene
polymorphisms with psoriasis in cases
from the Nile Delta of Egypt
A. Settin, H. Hassan, R. El-Baz, and T. Hassan
A B S T R A C T
K E Y
W O R D S
Psoriasis is a chronic, T lymphocyte–mediated
inflammatory disorder that affects the skin, joints,
and tendons in up to 4.8 percent of the world
population (1). The immune system involving Th1
cells in particular plays a dominant role in the
initiation and maintenance of psoriasis (2).
Recently, IL-6 has been assumed to play an
important role in the pathop