colon tissues probed by oligonucleotide arrays
Broad patterns of gene expression revealed by clustering analysis of tumor and normal
U. Alon, N. Barkai, D. A. Notterman, K. Gish, S. Ybarra, D. Mack, and A. J. Levine
doi:10.1073/pnas.96.12.6745
1999;96;6745-6750
PNAS
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Proc. Natl. Acad. Sci. USA
Vol. 96, pp. 6745–6750, June 1999
Cell Biology
Broad patterns of gene expression revealed by clustering analysis
of tumor and normal colon tissues probed by
oligonucleotide arrays
U. ALON*†, N. BARKAI*†, D. A. NOTTERMAN*, K. GISH‡, S. YBARRA‡, D. MACK‡, AND A. J. LEVINE*§
Departments of *Molecular Biology and †Physics, Princeton University, Princeton, NJ 08540; and ‡EOS Biotechnology, 225A Gateway Boulevard,
South San Francisco, CA 94080
Contributed by A. J. Levine, April 13, 1999
ABSTRACT
Oligonucleotide arrays can provide a broad
picture of the state of the cell, by monitoring the expression
level of thousands of genes at the same time. It is of interest
to develop techniques for extracting useful information from
the resulting data sets. Here we report the application of a
two-way clustering method for analyzing a data set consisting
of the expression patterns of different cell types. Gene expres-
sio