EXECUTIVE EMPLOYMENT AGREEMENT
N. ANTHONY COLES, M.D.
This AMENDMENT TO EXECUTIVE EMPLOYMENT AGREEMENT FOR N. ANTHONY COLES, M.D. (the “
Amendment ”) is made and entered into, as of March 12, 2009 (the “ Effective Date ”), by and between
ONYX PHARMACEUTICALS, INC. , a Delaware corporation (“ Company ”), and N. ANTHONY COLES, M.D.
(“ Executive ”). As of the Effective Date, the Company and Executive hereby amend that certain EXECUTIVE
EMPLOYMENT AGREEMENT FOR N. ANTHONY COLES between them entered into as of February 22, 2008 (the
“ Employment Agreement ”), a copy of which is attached hereto as Exhibit A , as follows:
1. AMENDMENT OF SECTION 2. 6(D) . Section 2.6(d) of the Employment Agreement is hereby amended
and restated in full:
(d) Housing Allowance and Restricted Stock Award. Executive will be eligible to receive the
following additional relocation benefits from the Company, which additional relocation benefits shall not be
subject to further modification or negotiation by the parties:
(i) Housing Allowance. For up to thirty (30) months after the Start Date, Executive will be eligible to
receive a monthly temporary housing allowance of $10,000 (the “ Housing Allowance ”), contingent upon his
continued employment, the after-tax amount of which shall be used for Executive’s rental or lease payments. The
Housing Allowance payments will cease immediately upon the closing date of Executive’s purchase of a
residence in the San Francisco Bay Area. The Housing Allowance will be subject to required payroll deductions
and withholdings, and will not be considered by the Company part of Executive’s Base Salary, including but not
limited to for such purposes as determination of the Annual Bonus, the Severance Benefits (described in Section
5.2(b)), or for the purposes of the Change in Control Agreement (described in Section 5.5).
(ii) Restricted Stock Award. Effective as of March 12, 2009, Executive wa