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<p> 2 The Shocking and Disturbing Truths Your Doctor Is NOT Telling You About Hypothyroidism, Testing, and Treatments Tom Brimeyer M.S. www.HypothyroidismRevolution.com 3 Hypothyroidism The Silent Killer My motivation for writing this report was simple Research continues to show that hypothyroidism is an epidemic problem that potentially affects more than one hundred million people in the US alone, most of whom go entirely undiagnosed while being treated for other unknowingly related health issues such as heart disease, stroke, cancer, diabetes, chronic fatigue, depression, autoimmune, and fertility issues, just to name a few. Despite the research, modern medicine continues to remain ignorant of the fact that the standard medical testing and treatment available to hypothyroidism sufferers today is far inadequate and ineffective to the point that it is practically useless. And if we continue to be complacent with and rely on inadequate and ineffective medical testing and treatment, the idea of making marked progress against hypothyroidism, and disease in general, will remain nothing more than a fantasy. But you have the opportunity and the power to make this your reality. In my struggles with my own hypothyroidism and health, I lost years of my life that could have easily been avoided. It wasn't until I discovered much of the research that I'll share with you in this report that I finally put the pieces of the puzzle together and was able to overcome my hypothyroidism and help countless others do the same. It's through this research that this Hypothyroidism Revolution was born and it's up to you as a Health Revolutionary to demand better medical care. In a world where hypothyroidism and its related diseases continue to rise year after year, it's up to you to reverse this trend and pave the way for a healthier, happier, and better future. Not only will this affect you and your health today but this revolution is for the greater good of changing and improving the health of our future generations. After reading this report, you WILL be smarter and more informed than your doctor. But it's up to you to decide what you will do with this knowledge. Where would we be today if more than a half a century ago everyone continued to accept the false idea that the world was flat? Where would we be today if more than two hundred and fifty years ago everyone continued to accept the false idea that harnessing electricity was impossible? Where would we be today if a hundred years ago everyone continued to accept the false idea that creating an automobile was unfeasible? Now, think about this. Where will we be tomorrow if we continue to believe the false idea that today's medical approach and treatment is the best answer to hypothyroidism? 4 Modern medicine continues to ignore the obvious connections between hypothyroidism and many of the most deadly diseases known to man, including heart disease, cancer, as well as a number of other diseases that are rapidly rising today. Because of this, hypothyroidism continues to be the most vile silent killer today as heart disease and cancer continue to kill at unprecedented rates. Simply looking at the leading causes of death, it's quite clear that heart disease and cancer are the two leading causes of death today, and both by astronomical margins. Yet, there's an enormous amount of research demonstrating the connection between hypothyroidism and both of these diseases. So much so that even researchers today are noting the overwhelming evidence. Here is an example. The following research not only proves that hypothyroidism leads to heart disease but it also mentions several other reports that have overwhelmingly proven the same exact connection. There are even studies, like the following one, demonstrating that thyroid hormone levels dictate the severity of the heart disease as well. Endokrynol Pol. 2005 Mar-Apr;56(2):194-202. [The influence of thyroid hormones on homocysteine and atherosclerotic vascular disease]. http://www.ncbi.nlm.nih.gov/pubmed/16335688 Excerpt: Several reports have appeared in the literature proving that hypothyroidism is associated with increased risk for cardiovascular disease, especially coronary heart disease. This increased risk for premature atherosclerosis is supported by autopsy and epidemiological studies in patients with thyroid hormone deficiency. 5 But let's take it even one step further There are also studies, like the next one, demonstrating that thyroid hormone levels are the most important predictor of death from heart disease. This means that the more hypothyroid you are or become, the greater your chance of dying from heart disease. Even if you're one of the millions who haven't been properly diagnosed by the poor medical testing available today, research has shown that sub-clinical or undiagnosed hypothyroidism results in the same increased risk of heart disease and death. Int J Cardiol. 2008 Mar 28;125(1):41-8. Epub 2007 Apr 16. Impact of subclinical thyroid disorders on coronary heart disease, cardiovascular and all-cause mortality: a meta-analysis. http://www.ncbi.nlm.nih.gov/pubmed/17434631 CONCLUSION: The present meta-analysis indicates that sub-clinical hypothyroidism is associated with both, a significant risk of CHD [Coronary Heart Disease] at baseline and at follow-up. In addition, mortality from cardiovascular causes is significantly higher at follow-up. Intern Med. 2012;51(21):3009-15. Epub 2012 Nov 1. A Low fT3 Level as a Prognostic Marker in Patients with Acute Myocardial Infarctions. http://www.ncbi.nlm.nih.gov/pubmed/23124142 Excerpt: Using a multivariable Cox proportional hazards model, the fT3 level was found to be the most important predictor of cumulative death and MACE. A Kaplan- Meier analysis revealed that those patients with low fT3 levels had higher rates of MACE and death. Conclusion: A low fT3 level, a common phenomenon in patients with acute myocardial infarctions, is a strong predictor of short-term and long-term poor prognoses in patients with acute myocardial infarctions. Clin Cardiol. 2003 Dec;26(12):569-73. Thyroid function is associated with presence and severity of coronary atherosclerosis. http://www.ncbi.nlm.nih.gov/pubmed/14677810 Excerpt: Higher levels of [T3] hormone concentrations were associated with decreased severity of coronary atherosclerosis. Higher levels of [TSH] concentrations were associated with increased severity of coronary atherosclerosis. 6 Believe it or not, this connection between hypothyroidism and heart disease has been well known for more than 70 years. The research presented above was all conducted in the 2000's but hypothyroidism research pioneers like Dr. Broda Barnes had proven the hypothyroidism heart disease connection as far back as the 1930's. Dr. Broda Barnes showed clearly through experimentation that when the thyroid gland was removed to induce hypothyroidism, heart disease developed rapidly. Yet, even today modern medicine continues to turn a blind eye and entirely ignore his research that could have been used to better prevent and treat heart disease for the past 70 years. This trend of scientific ignorance is now continuing with cancer research as well. The work of other brilliant scientists like Otto Warburg, who won the Nobel Prize almost a century ago for discovering and demonstrating the cellular defect that causes cancer, continues to be ignored by modern medicine to this day while more than a half a million people die of cancer every single year. Yet, even today research continues to prove what Otto Warburg discovered so many decades ago; hypothyroidism's role in the development of cancer. For example, the research recognizing the role of hypothyroidism and thyroid disease in breast cancer is overwhelming. Following are just a few of the research studies that demonstrate this: Eur J Cancer Prev. 1996 Dec;5(6):504-6. Thyroid disorders and breast cancer. http://www.ncbi.nlm.nih.gov/pubmed/9061284 Excerpt: These findings provide clear evidence of a relationship between thyroid disease and breast carcinoma Breast Cancer Res. 2003;5(5):R110-3. Epub 2003 Jun 5. Breast cancer in association with thyroid disorders. http://www.ncbi.nlm.nih.gov/pubmed/12927040 CONCLUSION: Our results indicate an increased prevalence of autoimmune and nonautoimmune thyroid diseases in breast cancer patients. 7 But the research is not limited to breast cancer alone. More and more research is showing the involvement of hypothyroidism in other forms of cancer, including lung cancer. Hypothyroidism's involvement in the disease process doesn't stop with heart disease and cancer. But I wanted to shed some light on these two in particular because they are responsible for nearly half of all deaths in the United States each year. Imagine how many unnecessary deaths could be prevented by simply focusing your attention on healing your thyroid. Imagine the improvements in the quality of life. The prevalence of other thyroid related diseases, like diabetes, which is currently the 7th leading cause of death, are rapidly increasing and more and more research is demonstrating the involvement of hypothyroidism in diabetes today. J Clin Endocrinol Metab. 2006 Sep;91(9):3337-43. Thyroid function is intrinsically linked to insulin sensitivity and endothelium- dependent vasodilation in healthy euthyroid subjects. http://www.ncbi.nlm.nih.gov/pubmed/16804039 CONCLUSIONS: Thyroid function tests are intrinsically linked to variables of insulin resistance and endothelial function. Br Med J. 1978 January 28; 1(6107): 210212. Thyroid function in lung cancer http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1602576/ Excerpt: Overall, the pattern of thyroid hormone metabolism in lung cancer was a tendency towards reduced T3 concentrations with significantly increased T4/T3 ratios and modestly increased 3,3,5-triiodothyronine (rT3) concentrations These data suggest that thyroid hormone metabolism is altered in patients with lung cancer by decreased 5-monodeiodination of T4. Thyroid. 2005 Nov;15(11):1253-9. Hypothyroidism might be related to breast cancer in post-menopausal women. http://www.ncbi.nlm.nih.gov/pubmed/16356089 Conclusion: Hypothyroidism and low-normal FT4 are related with an increased risk of breast cancer in post-menopausal women. 8 Hypothyroidism is truly the most deadly silent killer. The health of your thyroid is the most important factor in your overall health, and hypothyroidism plays a direct role in the development heart disease, cancer, and so many major diseases of today. Every single cell of your body relies heavily on thyroid hormone because without thyroid hormone, your cells cannot produce the energy they need to function properly and remain healthy. Think about it like this. If electrical system in your car wasn't able to produce an adequate amount of energy to keep your car running, your car would stop functioning and eventually die. The same is true for your cells and organs. Without adequate thyroid function, your cells and organs can't generate the energy they need to continue running, and your cells eventually become diseased and begin to die. Just think about the major implications that hypothyroidism can have on your health. Many of your body's most vital organs including your brain and heart rely heavily on your thyroid to maintain their energy and continue to function properly 24 hours a day, 7 days a week. Without adequate thyroid function, these vital organs struggle to function properly. Hopefully it's becoming clearer to you that your thyroid is directly responsible for the health of every cell, organ, and tissue within your body. And when thyroid function is impaired, every cell, organ, and tissue becomes susceptible to failure and disease. The health of your thyroid is far more important to your overall health than you realize. How Hypothyroidism Became So Mis/Undiagnosed One thing I've always found very interesting when talking with people about hypothyroidism is the large number of people who believe or suspect that they are hypothyroid even when their doctor and testing clearly show that they are not. It may be entirely intuitive for some. For others it's often a strong connection of their symptoms with the many symptoms of hypothyroidism. Regardless of the connection, I've found that most people are correct with their self diagnosis because of the poor testing methods used today. 9 Up until the late 1940's, hypothyroidism was successfully diagnosed and treated based primarily on a number of common symptoms and oftentimes on your Basal Metabolic Rate (BMR). Your BMR is entirely dependent upon your thyroid function. Doctors would determine your BMR by measuring your body's oxygen consumption, which would indicate your body's rate of metabolism. An inefficient use of oxygen was clearly a sign of hypothyroidism. Another one of the common symptoms oftentimes used to diagnose hypothyroidism was cholesterol levels. Research studies at that time, and still today, showed that your cholesterol levels were directly correlated to your thyroid function. When thyroid function is low, cholesterol levels rise. When the thyroid is stimulated to normal levels, cholesterol levels fall to within normal range. And so doctors began using elevated cholesterol levels as another indicator of hypothyroidism. The relationship between thyroid and cholesterol is easily explained through a basic understanding of the human body. Your body requires cholesterol, thyroid hormone, and vitamin A in order produce the hormone pregnenolone. Pregnenolone is a very important hormone because it is the precursor to all of the highly protective steroid hormones including two very important ones, DHEA and progesterone. When you are hypothyroid and lack thyroid hormone, then your body can't convert cholesterol as it normally would. Thus, your cholesterol builds up as a protective mechanism in attempt to stimulate the production of more protective hormones. At that time, the diagnosis was conclusive based on therapeutic trials. You would be treated for hypothyroidism while your measureable indicators (BMR, temperatures, cholesterol, etc.) were charted over time. If your symptoms improved as your indicators normalized, then the diagnosis was confirmed and treatment would continue. Based on these well accepted methods that were used at the time, hypothyroidism was commonly diagnosed and treated in 40-45 percent of the population. 10 Then, things quickly changed in the late 1940's when a new "scientific" test for hypothyroidism was introduced and promoted within the medical community. This particular test measured Protein Bound Iodine (PBI) in the blood, which was claimed to be a more accurate indicator of hypothyroidism. However, this was not the case. During the time when PBI testing became the gold standard, the rate of diagnosis of hypothyroidism dropped significantly to 5 percent. The other 35 percent were then being diagnosed as various other conditions such as overeating, mental illness, and unexplained disease. By the time that PBI testing was exposed as being very inaccurate, the medical community had already adopted this false belief that hypothyroidism existed in only 5 percent of the population. And so, this false statistic was carried over to newer forms of thyroid testing such as today's "gold standard" measurement of Thyroid Stimulating Hormone (TSH). When the reference ranges for the TSH test were established they were grossly inaccurate because they were made to fit this false 5 percent statistic instead of being based on true statistical values. So, even to this day, the reference ranges used for TSH testing do not make a bit of sense. As a result, 35-40 percent of today's population is hypothyroid and misdiagnosed by their doctor. So, unfortunately, they are being treated with a lifetime of prescription drugs to cover up their symptoms instead of being treated to correct the underlying cause of their problems. Even today, according to the National Endocrine and Metabolic Diseases Information Service "About 5 percent of the U.S. population has hypothyroidism." If you understand statistical distributions, as you can see from the image to the right that based on the revised 2003 "normal" TSH reference ranges that the prevalence of hypothyroidism must statistically be at least 20 percent. This is not debatable, this is purely mathematics. This only goes to show you that even today the medical community continues to ignore the true statistics as the same 5 percent estimation continues to be thrown around and accepted as accurate. 11 It is because of major problems like this that it is important for you to take an active role in your own health. Otherwise, you are relying entirely on a medical system that fails to understand the underlying cause of your health problems. Some of the leading hormone researchers today are arguing the danger and validity of today's newest "normal" TSH reference range of 3 microIU/L. They believe that the TSH level of a truly healthy thyroid is closer to, or even less than, 1 microIU/L. And that translates into a far greater prevalence of hypothyroidism, which more closely matches the 40-45 percent diagnosis that we seem to somehow have forgotten long ago. The Truth & Understanding of Hypothyroidism One of the biggest misconceptions today is that hypothyroidism is merely a problem with your thyroid gland. It is this type of over-simplified thinking that has gotten modern medicine in trouble to begin with. Doctors are trained to believe that hypothyroidism is simply caused by a lack of thyroid hormone and that giving thyroid medication is the sure, quick, and easy fix. But millions of people using thyroid medication every single day still complain of every hypothyroidism symptom in the book, and when you question your doctor, the typical response is that your symptoms are all in your head. The truth is that the health of your thyroid is far more involved than just the thyroid gland itself. There's an intricate thyroid hormone pathway with multiple working components, which all must be working properly together for your thyroid to function as it should and for you to be healthy. It's like trying to fill a bucket with water from a kinked garden hose. If there's a kink in the hose, you can turn the water pressure up as high as you want, but water can't flow through the hose to fill the bucket. The same is true for your thyroid. The only thing that matters is getting the right thyroid hormone to your cells. You can take all of the thyroid medication or hormones you want, but if there's a kink anywhere along your thyroid hormone pathway, you won't get the thyroid hormone to your cells and you will continue to remain hypothyroid regardless. This is one of the biggest downfalls of thyroid testing today. It doesn't tell you the most critical piece of information that matters more than anything else; whether or not you're getting any water into your bucket, or in other words, whether or not you're getting enough thyroid hormone to your cells. 12 This is something that I continually drum into my clients because it's critical for them to understand as they are going through the process of healing their thyroid. This isn't about just popping some pills and expecting miracles to occur. This is more about removing the kinks and giving your thyroid everything that it needs to do its job properly. You can do all of the testing you want, but it doesn't tell you the most important information that you need to know. You can use all of the supplements or thyroid medication you want, but it doesn't mean that you can get that thyroid hormone to your cells where it is needed. Regardless of how or why your thyroid hormone pathway becomes kinked, if you can't get the right thyroid hormone to your cells then you will remain hypothyroid until you address and correct the underlying cause(s) and undo all of the kinks that are suppressing your thyroid. The Shocking Truths About Thyroid Testing In today's society, we are raised with the idea that doctors are infallible. From a young age we are taught to trust everything that our doctor tells us, and that if we do, it is always for the benefit of our health. It's time to learn the truth. Remember, that chart above produced by the Center for Disease Control (CDC) showing the leading causes of death? Well, they forgot a big one. The leading study on preventable medical errors estimates that there are 180,000 deaths every year due to medical error, among Medicare beneficiaries alone. This isn't even accounting for those who use other forms of insurance outside of Medicare. By this statistic alone, this puts doctors at the third leading cause of death in the United States, right behind heart disease and cancer. Department of Health & Human Services Office of Inspector General Adverse Events In Hospitals: National Incidence Among Medicare Beneficiaries https://oig.hhs.gov/oei/reports/oei-06-09-00090.pdf Excerpt: An estimated 1.5 percent of Medicare beneficiaries experienced an event that contributed to their deaths, which projects to 15,000 patients in a single month. 13 I'm in no way saying that you should not trust your doctor. However, the days of simply placing your health into your doctor's hands are over. Today, we have to take our health into our own hands and become educated so that we can make the right decisions for our health instead of relying on a failing medical system. I mentioned previously how the standard thyroid testing used today is leaving millions of people undiagnosed, but even that is only scratching the surface of why standard thyroid testing is so unreliable today. Let's discuss some of the shortcomings of the most widely used thyroid test today. Thyroid Stimulating Hormone (TSH) Testing The TSH test is what most medical doctors use to diagnose hypothyroidism today. As I mentioned previously, this test is based on grossly exaggerated "normal" reference ranges that have led to a chronic under-diagnosis of hypothyroidism. It's not only a matter of bad science, but bad math as well. The first established "normal" reference ranges for this test were statistically established so that only 5% of the population would fall outside of the normal range and therefore be diagnosed with hypothyroidism. They forced the reference ranges to fit their false belief that only 5% of the population suffered from hypothyroidism. Based on prior decades of confirmed diagnoses it was widely understood at the time that hypothyroidism affected as much as 45% of the population. Although that is a big part of the problem, it is really only part of the problem. There's a whole other piece of the puzzle that gets completely overlooked when relying entirely on TSH measurements alone. Imagine again, if you will, that you're trying to fill a bucket with water from a kinked garden hose. Because the hose is kinked, no water can flow through the hose to fill your bucket. Regardless of how high you turn up the water pressure, the water can't get past the kinks in the hose. TSH is really just a measure of the water pressure. When your cells need more thyroid hormone then TSH generally rises to increase the flow of thyroid hormone. But if there's a kink in your thyroid hormone pathway, then you still won't be able to get thyroid hormone to your cells, regardless of your TSH level. 14 What's important to understand is that there are a number of extraneous factors that can effectively turn down the water pressure and lower TSH without addressing and correcting the kinks to your thyroid hormone pathway. So, you can manipulate and lower your TSH a number of ways, but that doesn't mean that you're getting the right thyroid hormone to your cells or that your thyroid function has improved. In many cases there are extraneous hormonal influences that can lower your TSH level and make it appear as if your thyroid is functioning normally, while in reality you are still very hypothyroid. Some of these include the hormonal influences of Aging Excessive Stress or Cortisol Infection Pain or Trauma Poor Dietary Choices Caffeine Fever Adrenaline Somatostatin Dopamine or L-dopa Amphetamine Feedback Effect of Thyroid Hormones Regardless of whether you realize it or not, most hypothyroidism sufferers who are treated using the standard medical treatment today of prescribing inactive T4 thyroid hormone medications like Synthroid or Levothyroxine are directly experiencing the feedback effect of thyroid hormones. Simply taking a T4 only thyroid medication will effectively lower TSH, but most people have a kink in their thyroid hormone pathway that prevents them from converting that T4 into the active T3 thyroid hormone that their cells need. So, they medicate and effectively lower their TSH, but they continue to fail to deliver the right thyroid hormone to their cells and remain hypothyroid regardless of what their test indicates. This is one of the biggest downfalls of modern thyroid testing today and will be discussed in more detail a little later in this report. There are even studies showing that 90% of hypothyroidism sufferers treated with the standard medical treatment continue to suffer from fatigue and various other hypothyroidism symptoms without improvement. 15 I've had a number of clients who have been told by their doctor that they needed to see a psychologist because their TSH was within normal range and they continued to complain that their symptoms had not improved with treatment. One client in particular came to me in tears because her doctor literally called her a liar to her face because despite medical treatment she continued to complain of fatigue and that she still wasn't able to lose weight no matter what she tried. By simply monitoring her temperature and pulse, she was able to understand that her medication wasn't working and that she still had all of her symptoms because she continued to be just as hypothyroid as she was prior to treatment. Once we addressed the kinks in her thyroid hormone pathway, she was amazed by the difference. So, as you can see, it is not always so cut and dry. There are many factors that affect your hormones and that make it impossible to rely on the level of one single hormone (TSH) to tell a much bigger story. It is definitely not enough evidence to rule out hypothyroidism, especially when your symptoms say otherwise. Additional Thyroid Testing Few doctors understand the inadequacies of TSH testing and are even willing to run additional lab testing to see more of the bigger thyroid picture. While this is a step in the right direction, and additional thyroid testing can provide more insight into the bigger picture, it still does not answer the most important question you need to know; whether or not thyroid hormone is able to get to your cells properly. As I have mentioned many times, you can supplement or medicate all of the thyroid hormone you want, but if you can't get the right thyroid hormone to your cells, it's a lost cause. So, we really don't have much choice but to take matters into our own hands and become educated as to all of the testing options available. Believe it or not, there is a far more reliable and more accurate test that your doctor is not telling you about and you don't even need your doctor to do it. The good news for you is that I'm going to show you the best way to test your thyroid function and answer the most important question that you need to know. By monitoring your temperature and pulse you can effectively measure your metabolism and thyroid function. Instead of measuring the water pressure of the hose, which isn't accurate by any means, you're directly measuring the amount of water that is getting into your bucket, or in other words, the amount of thyroid hormone getting to your cells. 16 Dr. Broda Barnes provided the research demonstrating just how effective monitoring your temperature can be, which I discuss in detail in my free report entitled, The Best Test for Hypothyroidism - Test From Home, For Free, and In 10 Minutes or Less. The Harmful Truths About Thyroid Treatments When it comes to treating hypothyroidism, most people fall into one of two groups. The first group consists of those who are treated by their doctor using thyroid medication. The other group consists of the ones who choose to treat themselves, most commonly with natural supplements. I hate to be the bearer of bad news, but in general, neither is effective and both can actually cause far more harm to your thyroid and your health than you realize. I'm going to discuss the two most popular treatment options out there that really deserve more attention because they can have some major health implications. T4 (Thyroxine) Supplementation For decades, doctors have been prescribing T4, the non-active form of thyroid, to patients. They do so with the belief that it will easily be converted into T3, the active form of thyroid that your cells can use, and as a result, it will alleviate your hypothyroidism. This includes prescription medications such as Synthroid Levoxyl Levothyroxine Unithroid Eltroxin Levaxin Norton Eutrosig Oroxine But, unfortunately, it's just not that easy. I want to introduce you to one of the most important research studies that your doctor is likely unaware of. 17 This research study analyzed both the symptoms and the active T3 thyroid hormone levels between untreated hypothyroid patients and patients that were treated with the standard T4 only medication that is used today. The results of this study show just how ineffective the standard T4 only medical treatment is. For starters, this study revealed that 90% of T4 treated patients continue to suffer from fatigue despite more than 3 years of treatment. But let's look at this even further According to the table above, taken directly from this study, the "Symptoms score" for the T4 treated patients were actually higher than those of the untreated patients. So, not only do T4 treated patients show no improvement, their symptoms tend to be slightly more severe than even untreated patients. Also, according to the table above, the measured active T3 thyroid hormone levels of the T4 treated patients were not significantly different than those of the untreated patients. So, we know that these patients being treated with the standard medical approach are not getting the right thyroid hormone to their cells and they are still effectively hypothyroid regardless of their test results. As seen in the above study, T4 treatment will effectively lower TSH, but in most cases, it does not improve thyroid function. Journal of Nutritional & Environmental Medicine, Volume 11, Number 3, 1 September 2001 , pp. 159- 166(8) Thyroid Insufficiency. Is Thyroxine the Only Valuable Drug? http://www.hypothyroidismrevolution.com/research/Is-Thyroxine-the-Only-Valuable- Drug.pdf Results: The group of 89 patients, treated elsewhere with T4, but still complaining of symptoms of hypothyroidism, did not really differ from the group of untreated hypothyroid patients as far as symptoms and 24 h urine free T3 were concerned. 18 Imagine yourself in pain and bleeding to death from a gaping wound and your doctor telling you that you'll be fine while just sending you home with a prescription for pain meds to mask the pain. You can use all of the pain meds you want and you might feel a little better, but it doesn't change the fact that you're bleeding to death. The pain meds are just covering up the more serious problem. Using T4 only medication does practically the same thing. It can effectively lower TSH and mask your hypothyroidism from standard testing, but it doesn't change the fact that you're still hypothyroid and that your health is still suffering big time. While some people do get a little bit of help from the T4, there are typically many factors that inhibit the conversion of T4 to T3, and this oftentimes causes a buildup effect of T4 in your body. While this non-active T4 builds up, your body begins to slow down your thyroid even further in order to stop from adding even more T4, hence the worsening of symptoms in the above study. So, in the end, these T4 only medications can have a negative effect on your thyroid and you can end up even more hypothyroid than when you started. Important Note Regarding T4 Only Medication: For those who are using T4 only medication for the treatment of hypothyroidism, I do NOT recommend stopping any medication prescribed by your doctor. In some cases, this can be detrimental to your health. It is best to consult with a professional regarding the best options and how best to work with your doctor for a more effective treatment. Iodine Supplementation There are a lot of doctors and practitioners out there that highly recommend the use of iodine for hypothyroidism. This is also a subject that can be quite misleading for many. Many years ago, goiters, which are a definite sign of hypothyroidism, were primarily caused by iodine deficiency. But today this is quite rare. Most goiters today are actually a result of excessive estrogen and/or progesterone deficiency that prevents the thyroid gland from releasing its stored hormones. So, while it's true that an iodine deficiency can cause hypothyroidism, this is rarely found today in developed countries. There are some tests out there that are still being promoted that supposedly tell you if you're deficient in iodine for the purpose of suggesting hypothyroidism. One such test suggests that you paint a spot of iodine on your skin and if the iodine disappears quickly then this is an indicator of a deficiency. 19 The biggest problem with this test is that it lacks scientific justification. For example, Iodine is easily converted into iodide by many substances such as vitamin C, glutathione, and thiosulphate. Iodide naturally is completely colorless. None of these reactions indicate an iodine deficiency. It is just a natural chemical reaction. But many people continue to use unscientific tests like this one as a way to self diagnose. This is definitely a problem, especially when it comes to iodine supplementation. While some scientists agree that 150 mcg (that's micrograms not milligrams) is a safe amount of iodine to take, many of the recommendations for iodine supplementation out there are a recipe for iodine toxicity waiting to happen. Most of the popular iodine supplements today are recommending the use of 12.5 milligrams or more. That's 83 times the recommended daily allowance. Many proponents of iodine therapy recommend as much as 50 milligrams to 100 milligrams of iodine daily which is 350 to 650 times the recommend daily allowance. This is a sure way to develop iodine toxicity, which is well known to be quite dangerous to your thyroid. An iodine excess like this can come with some pretty nasty side effects. Aside from the array of degenerative diseases it can cause, too much iodine can actually cause thyroiditis and can suppress your thyroid, making you even more hypothyroid than you were to begin with. There are plenty of studies that have demonstrated this: Science. 1985 Oct 18;230(4723):325-7. Induction of autoimmune thyroiditis in chickens by dietary iodine. http://www.ncbi.nlm.nih.gov/pubmed/4048936 Excerpt: These results suggest that excessive consumption of iodine in the United States may be responsible for the increased incidence of autoimmune thyroiditis. 20 Excessive iodine was once used to treat hyper-thyroidism because of iodine's ability to suppress thyroid function. However, in hypothyroid people or people with normal thyroid function, it has the same effect and can lower thyroid function far below normal. It's well understood by science that getting some exposure to sunlight daily is essential for your health. But it's also understood that excessive sunlight can be very damaging to your health. So, the idea that more is better doesn't always hold true, especially when related to health. The same applies to iodine. A little iodine is essential for our health, but today we get plenty of iodine from our food. Supplementing additional iodine will only cause more damage to your health. Excessive iodine can also suppress your TSH levels without stimulating your thyroid, which is yet another reason you can't rely on TSH testing. If you rely on TSH testing, you may be falsely led to believe that iodine is working to your advantage when in reality it is actually working against you and your thyroid. Presse Med. 2002 Oct 26;31(35):1670-5. [Hypothyroidism related to excess iodine]. http://www.ncbi.nlm.nih.gov/pubmed/12448334 WOLFF-CHAIKOFF'S EFFECT: The thyroid gland has a capacity to reduce thyroid hormone production in the presence of excess iodine by reducing the organification of the iodine. Thyroid. 2001 May;11(5):427-36. Iodine and thyroid autoimmune disease in animal models. http://www.ncbi.nlm.nih.gov/pubmed/11396701 Excerpt: In general, iodine deficiency attenuates, while iodine excess accelerates autoimmune thyroiditis in autoimmune prone individuals. Verh Dtsch Ges Pathol. 1996;80:297-301. [Spontaneous Hashimoto-like thyroiditis in cats]. http://www.ncbi.nlm.nih.gov/pubmed/9065031 Excerpt: Animals with excess iodide intake, however, show an aggravation of the autoimmune inflammatory activity. 21 Any Treatment that Doesn't Involve your Diet The right supplements at the right times can be a game changer with your health, but keep in mind that they are meant only to "supplement" an already healthy diet. This is yet another area where I find a major problem with hypothyroidism. Most people are looking for a supplement or drug that's going to fix their thyroid. They want to pop a pill, feel great, and be done with it without having to put forth any real effort. That's just not the way it works. If you're familiar with my Hypothyroidism Revolution Program, then you already understand how big of a part your diet plays in every case of hypothyroidism. Your diet has such a big impact on your hormones and thyroid that if you don't change your diet, then it's pretty safe to say that you will never truly correct the underlying problem. Your body needs the right vitamins, minerals, and nutrients in order to produce and properly regulate all of the necessary hormones in your body. Your liver needs selenium and the right amount of sugar to convert T4 to T3, the active form of thyroid hormone. Your body needs vitamin A and thyroid hormone in order to produce the hormone pregnenolone, which is the precursor hormone to a cascade of highly protective hormones that are essential to your health. And aside from getting the necessary nutrients, you have to make sure that you're not eating foods that have a negative effect on your thyroid function. For example, there are many foods, such as soy, that promote excessive estrogen in your body. And estrogen contributes directly to hypothyroidism and thyroid disease. Another very common example is eating the wrong kinds of fats in your diet. Studies have shown that polyunsaturated fats in your diet will block your thyroid hormone pathways on multiple levels. For starters, it directly blocks thyroid hormone secretion at the gland. It then blocks the hormone from being properly transported within your bloodstream to your cells. It even blocks the response of your cells to the hormones, therefore making the hormone far less effective. So, it's pretty safe to say that you should get comfortable with your health problems until you start feeding your body what it needs to correct the problem. 22 The Future of Hypothyroidism I hope that I've shed some light on this controversial topic of hypothyroidism for you and exposed some of the major flaws with how hypothyroidism is currently understood, diagnosed, and treated. I think that it's a pretty fair assessment to say that just about everything that is commonly accepted about hypothyroidism today is false. This has to change. Hypothyroidism has become a major financial burden, not only a personal level, but on a national level as well. While modern medicine continues to ignore the severity of hypothyroidism, its related diseases including heart disease and cancer are only going to continue to rise year after year. As the rate of disease rises, medical costs and insurance premiums will continue to rise as well until eventually medical care becomes too expensive to sustain. Look at how many people end up wiping out their entire savings along with their retirement savings because of ridiculous medical costs related to hypothyroidism. Today, medical costs are the leading cause of bankruptcy in the United States. Imagine how many people miss out on promotions, salary increases, advancement in the workplace, or even lose their jobs because they can't perform to their potential due to hypothyroidism. People invest their money for retirement and other purposes in order to make their future better and brighter. Living with hypothyroidism is like investing everything you have into a sinking ship. 23 But investing in your health and healing your thyroid is one of the best investments you can make. Showing people how to take their health into their own hands could make an astronomical difference. Simply educating people and teaching them how to periodically monitor their own temperature in order to determine the onset of hypothyroidism would save massive amounts in unnecessary medical costs. Doctors' visits would be minimized because patients would not have to continuously see their doctor and run dozens of unnecessary medical tests for chronic symptoms and conditions related to hypothyroidism that their doctor can't explain or properly treat. People would not be trapped into over-medicating themselves in an attempt to manage their various symptoms to the point that their liver becomes severely damaged, resulting in a number of other medical issues. One client of mine was on hormone replacement therapy and five different medications when she started working with me. We were even able to determine that a couple of her medications were partially responsible for driving her hypothyroidism. Now, she's off the hormone replacement therapy and her meds and it's saving her thousands of dollars every year. But most importantly, people would not feel helpless being trapped living a life of pain because their doctor has told them that their health issues are a genetic anomaly that they have no control over and need to come to terms with. It's time to make a change. It's Time for a Revolution I'm tired of hearing doctors tell their patients that their thyroid is permanently damaged and they'll have to take some sort of medication for life that doesn't even help. I'm tired of hearing doctors tell their patients that their diet has no affect on their thyroid health. I'm tired of hearing doctors tell their patients that their thyroid is fine and that they just need more medications to mask all of their other health complications that really stem directly from hypothyroidism to begin with. If you want real answers, if you want a better quality of life, if you want to finally feel like yourself again, then there is something that you can do about it. But, you have no choice but to take control of your own health. 24 I discuss some simple steps that I use with all of my clients and that you can use to start taking control in my free report entitled, 7 Simple Steps to Start Saving Your Thyroid. The Founding Fathers of the United States of America started the American Revolution because they believed that freedom and a better future were worth dying for. The Hypothyroidism Revolution is about believing in freedom of disease and creating a healthier future, but instead of having to die for it, you have to overcome hypothyroidism and live for it. This is about paving the way for and demanding better treatment options based on up to date research. This is about stopping the insanity and instead focusing on solving the problem instead of merely trying to sweep it under the rug. This is about learning how to help ourselves, but more importantly, helping our children and future generations so that they don't have to deal with a lifetime of disease and poor quality of life. This is about the desperate mother who came to me because her four year old daughter wasn't gaining weight, had dark circles under her eyes, was really behind in her motor and verbal development, was suffering from numerous food allergies, had chronic diarrhea, and was chronically fatigued to the point that she didn't even want to play. In a short period of time her diarrhea stopped, her energy returned, her cheeks began to fill out, and her weight began to normalize. This is about the mother who came to me because her five year old son wasn't himself, was overweight, experiencing joint pain, and was chronically fatigued to the point that he refused to walk. His energy returned, all of his symptoms diminished, and his weight began to decrease daily. I'll never forget it when she told me that her son was finally acting like a five year old again. If we're going to stop the negative health trend of rising disease, then we have to stand up today, put our foot down, and say enough is enough. We spend an estimated $150 Billion dollars every year on protecting our environment so that our future generations have a healthy place to live. But why, if our future generations are not healthy enough to even enjoy it? BE THE CHANGE YOU WANT TO SEE. 25 If we can focus on the right research and with the right plan, we can learn how to effectively address all facets of hypothyroidism that modern medicine continues to blatantly ignore. Together, we can make a difference. To your health, Tom Brimeyer M.S. www.HypothyroidismRevolution.com P.S. After reading this report you should understand why we can't rely on our current medical system to solve our health problems. We can't continue to rely on the inaccurate and inadequate testing and treatment options that doctors are prescribing today. But most importantly, you should now understand just how important the health of your thyroid truly is and how big of a role hypothyroidism plays in many of the most deadly diseases today, including heart disease and cancer. With this knowledge, you now know more about thyroid health than your doctor. I hope that you continue to build upon this knowledge and help pave the way for a healthier, happier, and better future. By learning how to address the underlying cause(s) of hypothyroidism we really can make a difference and take back our health in the process. If you like what you've learned in this report and you want to learn more about what you can do to overcome your hypothyroidism, then you might also be interested in a free presentation that I put together outlining the 3 Step Process that I use with my clients to help them stop hypothyroidism directly at the source and take back their lives. Click Here to Watch Your Free Presentation Explaining My Exact 3 Step Hypothyroidism Treatment Process 2 The BEST Test for Hypothyroidism Test From Home, For Free, and In 10 Minutes Or less Tom Brimeyer M.S. www.HypothyroidismRevolution.com Disclaimer: The author is not a medical doctor and this information is for educational purposes only and may not be construed as medical advice. It is meant to supplement, not replace, the professional medical advice of your health care provider. No part of this report may be sold, resold, traded, reproduced, edited, or transmitted in any format without prior consent of the copyright owner. 3 Understanding Your Thyroid Testing Options I wrote this report for you for a number of reasons. For starters, I wanted to share with you one of the most accurate techniques for testing your own thyroid function that is being used by myself and some of the other most highly skilled thyroid practitioners out there today. I'm going to show you just how effective this technique can be if used properly and the absurd reasons why your doctor doesn't want you knowing about it. But, I also wrote this report with the intention of helping you to save a lot of unnecessary time, money, and hassle by helping you get real answers instead of constantly getting the run around with your hypothyroidism. No, you don't have to be a doctor or receive extensive medical training to test your own thyroid. In fact, the less medical training you have the better, and I'll show you why. So, let's get right to it Over the past hundred years, there have been many tests that have been developed to screen for hypothyroidism and monitor the function of your thyroid. Some of the early tests were quite effective. However, over the years modern medicine seems to have taken many steps in the wrong direction with the development of more technologically advanced testing. Many of problems associated with today's testing are covered in detail in my free report entitled, Why You Still Have Thyroid Symptoms and Why Doctors, Drugs, and Labs Are Failing You. In this report, I'm going to focus more on the three most common thyroid testing options that are readily available today along with the advantages and disadvantages of each. 1. TSH (Thyroid Stimulating Hormone) Testing Odds are that if you've been tested for hypothyroidism by your doctor, then you've had your TSH level measured and they may have been above "normal" (at least the medical interpretation of normal that is). This is currently the standard test that medical doctors use to diagnose hypothyroidism today. And it's the ONLY test they typically run. While TSH is a test that is generally covered by medical insurance and is measured simply through a blood draw, it has a number of disadvantages. If you're not familiar with human physiology, TSH is a hormone that tells the thyroid gland that more thyroid hormone is needed and to release more thyroid hormone into your bloodstream. So, if TSH is high then this is thought to mean that your thyroid gland is not able to produce adequate thyroid hormone, thus you must be hypothyroid. 4 Think of your thyroid like using a garden hose to fill a bucket. The faucet represents your thyroid gland, the hose represents your thyroid hormone pathway, the water represents your thyroid hormone, and the bucket represents your cells that rely on getting adequate thyroid hormone to survive and function properly. TSH is the equivalent of the water pressure. Normally, when you turn the water pressure up then you get more water (thyroid hormone) into your bucket (cells). But what happens if your garden hose (thyroid hormone pathway) is kinked and water (thyroid hormone) can't get through? You can turn the faucet on as high as you want, but regardless of how high the water pressure is you can't get any water (thyroid hormone) into your bucket (cells). This is one of the biggest problems with relying on TSH testing. It's simply a measure of how stimulated your thyroid is, but it doesn't tell you the most important piece of the puzzle that you need to know which is how much thyroid hormone you're getting into your cells. TSH testing can be influenced by a number of extraneous factors unrelated to the direct function or health of the thyroid gland including: Aging Stress Infection Blood Sugar Excessive T4 Etc. It's important to understand that any thyroid test is merely giving you a snapshot of your hormone levels at one single moment in time. Any factor, including the list above, can cause an immediate or drastic change in your hormone levels. So, let's say you're under a considerable amount of stress, you've caught a cold, or you didn't have time to eat before your doctor's appointment these variables can affect the outcome of your test and lead to false results. There are a number of factors that can drive TSH down to within "normal" range without actually removing the kinks in your thyroid hormone pathway or helping you to get the right thyroid hormone you need to your cells. 5 For example, doctors typically prescribe T4 only medications like Synthroid or Levothyroxine that can easily lower TSH without actually delivering more of the right thyroid hormone to your cells or improving your thyroid function. The most important piece of the puzzle that you need to know is how much thyroid hormone you are getting to your cells and simply looking at TSH alone is highly inaccurate and leads to millions of people suffering with either undiagnosed or misdiagnosed hypothyroidism every day. Another reason why TSH tests are highly inaccurate is that they are based entirely on illogical reference ranges. Any lab test is only as accurate to the degree that its reference ranges are accurate. And there is a lot of evidence surrounding the illogical reference ranges that have been established for TSH. The original TSH reference ranges were based on the results of the Protein Bound Iodine test, which was one of the many tests that have been deemed entirely inaccurate and unreliable. So, basing TSH reference ranges on a test that was proven to be inaccurate and unreliable makes the results of the TSH test inaccurate and unreliable at best! 2. Additional Thyroid Blood Testing There are a number of blood tests available for measuring various factors related to the thyroid hormone pathway including TSH, T4, T3, reverse T3, T3 Resin Uptake, Thyroglobulin, etc. One of the biggest benefits to additional blood testing is that if you understand the physiology and roles that all of these hormones play within the human body, then you can begin to gain some insight into what the potential problems, or kinks, are that are disrupting your thyroid function. However, they still do not answer the one single question that continues to elude modern medicine even today, which is how much thyroid hormone is actually getting to and being used by your cells. 6 Looking at these various other hormone levels in the blood is the equivalent of taking a water sample from your kinked garden hose and analyzing the quality of the water. You can analyze that water all you want but it's still not telling you if you're getting any of that water (thyroid hormone) into your bucket (cells). There are a number of physiological and dietary factors that can block thyroid hormone from actually being used by your cells. Thyroid hormone can be blocked in your bloodstream and it can even be blocked at the cell receptors themselves. Aside from the fact that additional blood testing doesn't give you the most important piece of the puzzle that you need to know, it's also quite expensive and oftentimes deemed unnecessary under medical insurance standards. That's why so many patients end up having to pay hundreds or thousands of dollars out of pocket for these labs and still continue to get nowhere with the inadequate medical treatment available today. 3. Monitoring Your Temperature and Pulse The idea of monitoring temperature as an indicator of thyroid function is not a new concept. It has been effectively used for more sixty years and proven to be one of the most accurate indicators of hypothyroidism, even today. As mentioned previously, one of the biggest issues with relying on blood testing, whether it be for TSH, various other thyroid hormones, or otherwise, is that while those tests can give you insight into some of the various issues that can be disrupting your thyroid function, they fail to answer the most important question of whether or not your cells are able to get and utilize adequate thyroid hormone. While it doesn't give you all of the pieces of the puzzle, simply monitoring your temperature and pulse can effectively give you the most important piece. Your thyroid is directly responsible for controlling your metabolic rate, or the rate at which your cells produce energy. When thyroid function is good, your cells are able to utilize thyroid hormone effectively and maintain a temperature of 98.6F (37C) throughout the day. When you become hypothyroid and your cells are NOT able to utilize thyroid hormone properly, then your temperature will generally run lower. By monitoring your temperature and pulse, you are effectively able to measure exactly how much water (thyroid hormone) you are getting into your bucket (cells). 7 Because you are directly measuring your cells use of thyroid hormone, you are effectively measuring the end result, which no other current medical test can measure, making this the most accurate test available. Modern medicine today continues to completely ignore the kinks in your thyroid hormone pathway and just assumes that by simply giving you thyroid hormone medication it will somehow magically bypass all of these kinks and get to where it needs to go. Unfortunately, it doesn't work that way. Not only does monitoring your temperature and pulse give you the most important piece of the puzzle, it's comes with a lot of additional advantages. For example, it's entirely free, easy to do yourself, and can be used far more effectively and accurately to track your treatment progress. With the billions of dollars invested each year in medical research and the amazing advancements in medical technology, you would think that we would be able to diagnose hypothyroidism today with 99% accuracy. Heck, I'd even settle for 75% accuracy, but we're still missing that mark by a long shot. Let me tell you, computer technology today may be advancing at light speed but in many other areas of technology we're still scratching our heads. It reminds me of my days as an engineer when I was introduced to a navigational program that was still using navigational technology developed by German scientists 70 years ago during WWII. For the past 70 years American scientists have been trying to improve this German design and have achieved nothing but 70 years of failure. Sometimes, it's a lack of knowledge that slows technological advancement, but when it comes to healthcare, more often than not, it's ignorance that impedes progress. In the same respect, it's ignorance that allows us to continue to rely on inaccurate thyroid testing while ignoring a simple test that was developed more than 70 years ago to more accurately diagnose hypothyroidism. However, even this cloud has a silver lining. If you can learn how to take your health into your own hands and effectively test your own thyroid function better and more accurately than your doctor, then you can use this to your advantage in treating your own hypothyroidism better and more effectively than your doctor as well. 8 Low Body Temperature and Hypothyroidism Low body temperature is an epidemic problem. I have personally spoken with nurses and have heard stories from others in the medical field who chart temperatures all day long and who openly admit that it's rare to find anyone today with a 98.6F (37C) temperature unless fever is present. In my own practice, I see the same exact thing. Low body temperature is more often than not, an indicator of hypothyroidism. Am I saying that everyone today is hypothyroid? Of course not, but it's well known that hypothyroid people get sick more often and are far more likely to develop health complications and disease. So, it should be understandable that the majority of people being seen in hospitals and doctors' offices for health problems today are far more likely to be hypothyroid. Your thyroid is responsible for controlling and regulating a large number of functions within your body including: Metabolism and Heat Production Circulatory System and Blood Volume Muscular Health Nerve Health Digestive Health Health of Every Organ Health of Every Tissue Health of Every Cell But today, we don't even stop to consider the potential impact that thyroid health has on every function of the human body, and instead we only focus on its impact on our metabolism and our ability to lose weight. Every cell in your body relies on thyroid hormone to produce energy and remain healthy. When your cells use thyroid hormone, they produce more energy and therefore more heat. When your cells are starved of thyroid hormone, they produce less energy and therefore less heat. By simply measuring the heat that your cells, or body, produce at rest can give you direct insight into how much thyroid hormone your cells are using. And as I've mentioned many times before, TSH tests, blood tests, and all other thyroid tests DO NOT tell you how much thyroid hormone your cells are actually using, which is the only true way to accurately diagnose hypothyroidism. 9 Why Your Doctor Doesn't Want You Taking Your Own Temperature If measuring your basal body temperature is so simple and effective, then why does your doctor dismiss its relevancy? There are two reasons which are quite simple 1. Your doctor didn't go through 8 years of schooling and 3 to 5 years of residency just to let his or her patients self-diagnose themselves by simply using a thermometer. Of course not, and doctors understand that they have to protect their profession because they are the so-called "experts" when it comes to your health, not you. What would the world become if people started taking a more active role in their own healthcare and demand proper treatment? So, instead of even trying to argue the relevancy of basal body temperature, modern medicine has chosen to turn a blind eye and simply ignore it altogether. 2. Healthcare today is a business. And like any business, they want to maximize their profits. How much money do they stand to make by having you take your own temperature? Absolutely nothing It's much more profitable to charge you for an office visit to draw your blood, charge you for the blood test itself, and then force you to come back to their office so that they can charge you yet again for another office visit just to read you the results of your test. Multiply this times twenty, thirty, or forty years of seeing your doctor and you've done your part to pay for his or her new vacation home. Many people continue to wonder why the cost of healthcare continues to rise year after year. Unnecessary testing sure isn't helping, nor is improperly treating people for health problems that stem entirely from hypothyroidism to begin with. I personally know someone who was kicked out of their doctor's practice because they requested to receive their blood test results by phone and refused to go in and pay for an office visit they didn't see as necessary. It's like taking your car to a mechanic who charges you two hundred dollars to look under the hood, change your air filter, and shine your windows. If you can do it yourself for next to nothing, then why would you keep going back to the same mechanic and throwing your money down the drain? 10 The Most Accurate Test for Hypothyroidism I want to share with you one of the easiest and most accurate ways to determine whether or not you suffer from hypothyroidism. One of the most unfortunate aspects of this way to test for hypothyroidism is the fact that it doesn't cost you a dime. I say this is unfortunate because the medical community shows little to no interest in testing that they cannot profit from. So, instead of accurately diagnosing the many people who are suffering from hypothyroidism, they rely on expensive lab tests that make them a lot of money while providing very poor results. Monitoring your Morning Temperature and Pulse Yes, your morning temperature and pulse together are very accurate indicators of hypothyroidism, if you measure them properly. Monitoring your morning temperature was a concept that was pioneered by an American doctor by the name of Broda Barnes. Dr. Broda Barnes studied hormonal issues and argued against the medical community that hypothyroidism was widely under-diagnosed. He spent more than 50 years researching and proving that hypothyroidism was the underlying cause of heart disease today. Even though nobody has been able to invalidate his research, his work has been, and continues to be, completely ignored by modern medicine today. In 1942 he published a study demonstrating the effectiveness of basal temperature in diagnosing hypothyroidism and its ability to prevent misdiagnoses that to this day continue to lead to unnecessary operations to remove the thyroid gland, leading to unnecessary severe health complications. JAMA. 1942;119(14):1072-1074. doi:10.1001/jama.1942.02830310006003. BASAL TEMPERATURE VERSUS BASAL METABOLISM http://jama.jamanetwork.com/article.aspx?articleid=256690 SUMMARY 1. From a study of over 1,000 cases the results indicate that subnormal body temperature is a better index for thyroid therapy than the basal metabolic rate. 2. The differential diagnosis between hypothyroidism and hyperthyroidism is sometimes difficult. In 7 cases reported the diagnosis was wrong, in 5 of which an operation had been performed. The temperature was subnormal in each case. 11 While Dr. Broda Barnes and his work were very advanced for his time, there were still some factors that morning temperatures didn't account for. Most notably, it didn't account for changes in air temperature. Respected endocrine physiologist Dr. Raymond Peat discovered that in warmer climates your morning temperature was not always the best indicator of hypothyroidism. When the air temperature around you is warm, then your thyroid doesn't have to do much work to maintain your core temperature of 98.6F (37C). It doesn't make sense to measure your thyroid's capacity to work during a time that it doesn't have to work very hard. Dr. Peat also noticed a trend of low pulse rates with those who suffered from hypothyroidism, even when their core temperatures were influenced by the warmer air temperature. But when these people took a thyroid supplement, their pulse rates returned to normal. So, by taking into account your morning temperature and pulse rate together, you get more accurate results than with morning temperature alone. A Note About Your Pulse I think that this is an important point to make because so many people have the wrong idea when it comes to understanding what a healthy pulse rate is. For one reason or another, it is very common to think that the lower your pulse the better. However, nothing could be further from the truth. Nutrients are delivered to your cells through your blood. The slower your pulse is, the fewer nutrients you are getting to your cells. These are nutrients that your cells need in order to function properly and maintain a healthy energized state. If your cells become starved, which is very common with hypothyroidism, they become easily damaged and dysfunctional. Also, keep in mind that there is a point that in which your pulse is considered too high. I'll touch on this more in a second but this is typically driven by excessive stress hormone production. 12 Morning Temperature Ranges When taking your morning temperature, for the most accurate results, you should keep a thermometer by your bedside and take your temperature before getting out of bed or moving much. Also, when using a digital thermometer, it is sometimes necessary to hold the thermometer in place for a minute or two before taking your temperature to ensure that the measurement is accurate. A morning temperature of 97.8F (36.5C) or less is highly indicative of hypothyroidism. It is important to monitor your temperature and pulse again after breakfast in order to factor out the influence of adrenaline. This is because high stress hormones can give you false normal or even high temperature and pulse measurements. This is most common in people with hypoglycemia or low blood sugar. As your blood sugar drops overnight, your stress hormones rise. The stress hormone, adrenaline, will both raise your core temperature and increase your pulse rate, which can give you false measurements in the morning. By eating breakfast and regulating your blood sugar, your stress hormone levels will return to normal. So, re-testing 20 minutes after you eat breakfast can give you a better indication of your true thyroid function or basal metabolic rate. If your thyroid is functioning properly, then after breakfast you should see your temperature increase from around 97.8F (36.5C) up to the normal 98.6F (37C). If you are affected by high adrenaline levels, then you will see your temperature and/or your pulse rate fall after breakfast. If adrenaline is not an issue, then your temperature and pulse rate should rise after breakfast. Afternoon Temperature Ranges I also advise on monitoring temperature for a third time around 3 p.m. in the afternoon as an indicator of thyroid function later in the day. If your thyroid is functioning properly, then after breakfast and continuing through the afternoon, your temperature should remain consistently close to 98.6F (37C). If your temperature has dropped in the afternoon, this is another sign of hypothyroidism. Pulse Ranges According to Dr. Peat, the average resting heart rate of a healthy person is 85 beats per minute. Less healthy people have an average closer to 70 beats per minute, which oftentimes is another indication of hypothyroidism. 13 Special Considerations for Women of Reproductive Age As with everything, there are still going to be special considerations that need be accounted for, especially for women of reproductive age. If you are a woman who is still menstruating monthly, then your temperature will fluctuate with your menstrual cycle. For example, women have been monitoring their temperatures for centuries to determine the precise time of ovulation. A woman's temperature will be lowest at ovulation and then rise during the second half of her cycle before normalizing during menstruation. Then, after menstruation, during the first half of her cycle, her temperature will tend to be lower, again dropping at ovulation. Because of this, you have to factor out these influences that your cycle has on your temperature in order to get the most accurate results. If you monitor your temperature during the second half of your cycle, it may by artificially elevated and appear normal leading to false results. Because of this, it's best to measure your morning temperature on days two through four of menstruation for most accurate results. Extraneous Influences on Temperature It's also important to note additional factors that can influence your core temperature, especially in the morning. Influence of Infection Oral temperature can be used but it's well known that even the common sinus infection can raise oral temperature leading to false results. If there's any possibility of infection, then it's best to use underarm temperature instead. Extraneous Influences There are many other extraneous influences that should be considered as well. For example, sleeping under an electric blanket will artificially increase your body temperature. Artificially raising your body temperature through exercise or even a hot bath can also influence results. 14 How to Test and Interpret Your Results Now that you understand the importance and accuracy of monitoring your temperature and pulse as a test for thyroid function, I want to break everything down into a few simple steps that you can follow and explain exactly how to interpret your results. On the last page of this report, I've provided a Thyroid Testing Record Sheet that I use with my own clients. You should print this record sheet and use it to start recording your own temperature and pulse to test your own thyroid function. Once you have your record sheet printed, follow the instructions below: Preparation: 1. Place a thermometer and watch within arm's reach by your bedside before you go to sleep. If using a mercury thermometer, be sure to shake it down. 2. Go to sleep and avoid eating anything in the middle of the night as digestion can affect basal metabolism. Monitoring Your Temperature and Pulse 1. Upon awakening in the morning, being as still has possible, reach for your thermometer by your bedside and sit completely still in bed while taking your temperature for about 5 to 10 minutes. If using a digital thermometer, it's best to leave it in your mouth for a few minutes, prior to turning it on for most accurate results. Using your watch, measure your pulse. Record your results on the record sheet. 2. Wait 20 minutes after breakfast and while at rest, using your thermometer and watch, measure your temperature and pulse and record them in the appropriate locations on your record sheet. 3. Around 3 p.m. in the afternoon, while at rest and at least 20 minutes after eating or drinking, use your thermometer and watch measure your temperature and pulse. Record it in the appropriate location on your record sheet. Important Notes: 1. Always measure your temperature and pulse while at rest. Measuring your temperature and pulse after physical exertion or while being stressed or rushed can affect the accuracy of the results sheet. 2. If you are a woman of reproductive age, then you should record your temperature and pulse during days 2 through 4 of your menstrual cycle. 15 Interpreting Your Results Below are some simple guidelines for interpreting your results. I've also included a simple process map on the following page to help walk you through the interpretation. Morning Basal Temperature If your morning basal temperature is 97.8F (36.5C) or less, then this is highly indicative of hypothyroidism regardless of other temperature and pulse measurements. If your morning basal temperature is above 97.8F (36.5C), then you must compare it to your post-breakfast temperature to rule out the influence of stress hormones. Post-Breakfast Temperature If your morning basal temperature was within normal range, but your post-breakfast temperature falls below your morning basal temperature, then this is indicative of hypothyroidism and excessive nighttime adrenaline production. Your recorded morning basal temperature is not accurate and your post-breakfast temperature is closer to your true morning basal temperature. If your morning basal temperature was within normal range, but your post-breakfast temperature does not rise close to 98.6F (37C), then this indicates hypothyroidism. If your morning basal temperature was within normal range and your post-breakfast temperature rises close to 98.6F (37C), then you must compare it to your afternoon temperature. Afternoon Temperature If your afternoon temperature is well below 98.6F (37C), then this is indicative of hypothyroidism. If your morning basal temperature was within normal range and both your post- breakfast and afternoon temperatures are at or close to 98.6F (37C), then you need to account for your pulse. Pulse Measurement If your pulse is consistently below 80 to 85 beats per minute, then you are likely hypothyroid. If your temperatures are all normal throughout the day and your pulse is consistently 80 to 85 beats per minute, then your thyroid function is good. 16 17 Don't Underestimate the Importance of Your Pulse When you have very little fuel in your gas tank you can't get very far before you run out of gas or have to find a way to put more fuel in your tank to keep your car running. The same occurs when you're hypothyroid. When your cells don't get enough thyroid hormone they stop functioning properly and their energy production declines along with your temperature. If your cells ran out of fuel entirely, then life as you know it would cease to exist. As a means of survival, your body is designed to sacrifice long term health for the short term gain of survival. Because of these inherent survival mechanisms, primarily through the generation of certain stress hormones, oftentimes hypothyroidism sufferers will exhibit artificially elevated temperatures. While some may misinterpret this as healthy thyroid function, this is equivalent to putting low grade gasoline into a car that requires premium grade gas. Sure, your car will continue to run, but your engine will lose power, your gas mileage will suffer, and eventually your engine fail and you're car will die. The same goes for your thyroid. If you're relying on stress hormones to keep your temperature artificially elevated, then your cells won't be able to produce energy effectively, your thyroid will down-regulate further lowering energy production, and eventually your cells will begin to fail leaving you in a heap of trouble. This happened to one of my clients after thinking for years that her thyroid was healthy, when in reality it wasn't. Her temps were consistently in the normal range but her pulse was consistently around 55 beats per minute, which was not a good sign. She still suffered from a number of hypothyroidism symptoms and while she felt as if she had plenty of energy, she could never sit still or else she would crash. When she started working with me, we immediately addressed her stress hormone issues and in the process her temperature dropped almost immediately to around 97F (36.1C), which was her true temperature. Then by properly regulating her thyroid so that her cells were getting and utilizing thyroid hormone instead of her running on stress hormones, her temperature normalized, her pulse began to increase steadily, her symptoms disappeared, and she finally experienced the healthy type of sustainable energy. Let this be a lesson to you. Never disregard your pulse as an indicator of hypothyroidism because it plays just as big of a factor as your temperature. 18 Take Action and Start Testing Yourself By using the exact steps that I've laid out for you in this report along with the Thyroid Testing Record Sheet provided below, you no longer have to settle for inaccurate medical tests that don't answer the most important question that you need to know in determining the health of your thyroid. With the right plan of action that addresses all of the underlying causes of hypothyroidism to remove the kinks that are suppressing your thyroid, you can effectively use this testing method that I've laid out for you to watch as your thyroid heals. As your thyroid heals over time, you'll notice fewer and less severe temperature fluctuations through your day, along with fewer and less severe energy and mood swings. Over time, you'll see your temperatures throughout the day begin to stabilize and rise along with a rise in your level of energy and sense of wellbeing. Over time, your morning basal temperature will begin to regulate and you'll wake up feeling happier and more refreshed from much improved sleep. Over time, your post-breakfast temperature will begin to rise quickly to normal and you'll feel a significant sense of energy and readiness to start your day. Over time, all of the important systems within your body will be properly energized again and regulate properly as your symptoms begin to disappear and you return to your happier and healthier former self. I've watched clients experience what they believe to be miracles, and the longer they allow their thyroid to heal, the bigger the miracles they experience. It's like trying to repair a broken road. You need a well laid out plan and you have to put in the work to fix it right so that you can rely on it for your entire lifetime. But this isn't always the easy route and can take a little time to do it right. You have to remove the broken pieces. You have to backfill the voids. You have to properly compact and level the ground. You have to repave the road in order to reconnect both ends. And you have to do it all in the right order. When you do this, the road will start working perfectly again, just like it use to. 19 Healing your thyroid works in much the same way. You need a well laid out plan that addresses all of the underlying cause(s) of hypothyroidism. You have to put in the work to fix your thyroid the right way so that your health will last you a lifetime. It does require time and effort, but the most rewarding things in life always do. You have to correct the broken pieces and fill the voids of your thyroid that are preventing you from healing. Once you do this, and in the proper order, you're thyroid will start working perfectly again just like it use to. Sure, you could simply dump in some dirt and throw down a few rickety boards. That may last for a week or two before it erodes or gets washed away, but this would leave your road in ruins again, forcing you to start rebuilding from scratch. So many people do this with their health by simply trying to fill their void with one supplement after another, hoping to eventually find some sort of glimmer of hope. But it never works and they always end up right back where they started. If instead they would have simply focused on following the right plan from the beginning, they could have corrected the problem directly at the source, saving themselves a lot of time, money, and heartache. With the right plan, anything is possiblelike my client who over the course of a few months saw her temperature and pulse return to normal, her T3 and T4 levels return to normal, her TSH drop from 6.2 to 1.77, and her energy levels change drastically shortly after committing herself to the necessary dietary improvements. The resources you need are right in front of you. It's simply a matter of whether or not you choose to continue to rely on the inadequate medical testing and treatment available today, or you choose to say enough is enough and stop wasting your money and start taking control of your own health starting with measuring your own temperature and pulse. I have faith that you'll make the right decision for you. (Don't forget the Thyroid Testing Record Sheet on the last page ) To your health, Tom Brimeyer M.S. www.HypothyroidismRevolution.com P.S. In this report, we've covered your thyroid testing options in detail and why you can't rely on the highly inaccurate medical tests used today. We also covered why measuring your temperature and pulse is the only truly accurate way to determine the function and health of your thyroid. 20 I've given you my powerful step-by-step plan that maps out the most accurate and effective way to measure your own thyroid function from home, for free, and in 10 minutes or less. By using the right plan and addressing all of the underlying cause(s) of hypothyroidism, you can easily use the testing method that I showed you in this report to watch your energy increase and your symptoms disappear as your temperature and pulse regulate and return to normal over time. This is exactly what I do with my clients. They use the same exact thyroid testing method to track their own progress as their thyroid heals. If you like what you've learned in this report and you want to learn more about what I do with my clients to help them overcome hypothyroidism, then you might also be interested in this free presentation that I put together for you. It explains the system that I used myself and continue to use with my clients to help them stop hypothyroidism directly at the source and take back their lives. Click Here to Learn More About the Safest, Natural, and Only Way to Truly Overcome Hypothyroidism 21 1 7 Simple Solutions to Hypothyroidism Natural and Necessary Steps to Successfully Beat Hypothyroidism Tom Brimeyer M.S. HypothyroidismRevolution.com HypothyroidismExercise.com 2 Table of Contents My Story.. 3 The Importance of Your Thyroid to Your Health.. 7 7 Simple Solutions to Hypothyroidism ..... 8 Solution #1 Balance Your Estrogen Levels... 9 Solution #2 Manage Your Stress Hormones..... 11 Solution #3 Restore Your Liver Function... 13 Solution #4 Eat the Right Proteins... 14 Solution #5 Balance Your Blood Sugar.. 15 Solution #6 Avoid Polyunsaturated Fats.... 16 Solution #7 Stop Over-Exercising.... 18 Closing Thoughts on Hypothyroidism... 20 3 My Story Hi, My name is Tom Brimeyer and I am a practitioner of functional medicine and health researcher and I have been lucky enough to study with and learn from some of the most widely sought after and knowledgeable doctors, health practitioners, and health researchers in the world. Through my own struggle with chronic health issues, I was introduced to functional medicine many years ago. Ever since that first door opened, I've found myself digging deeper and deeper into this both exciting and very misunderstood field of health. Since then, door after door has opened for me which has allowed me to gain a vast understanding of the human body and how to directly influence your health to overcome a wide array of chronic health problems. Since 2006, I have enjoyed both a personal transformation and evolution of sorts that has allowed me to become personally and actively involved in the health and lives of countless people all over the world. This includes the United States, Canada, United Kingdom, Ireland, Australia, New Zealand, Sweden, China, and the list is growing quickly. I have helped hundreds of these people overcome chronic health issues such as chronic fatigue, hypothyroidism, insomnia, depression, anxiety, hormonal imbalances, digestive issues, food allergies, hypoglycemia and hyperglycemia, adrenal fatigue, dysbiosis, parasitic infections, arthritis, chronic inflammation, osteoporosis and osteopenia, as well as a variety of immune conditions and disorders. Yet, this is only the tip of the iceberg as far as I am concerned. And as I continue to grow my work and practice to reach more and more people, I look forward to being a major contributor to igniting what I consider to be the inevitable coming of the Health Revolution. I believe that a much needed radical shift in our mindset and understanding of health is in the making. 4 This very thinking is what started and continues to feed my own personal mission. My Personal Mission: To inspire and educate more than 1 Million people to take control and achieve true health by finding and fixing the underlying cause of their health problems instead of being stuck relying on prescription drugs that merely cover up their symptoms while their health continues to suffer. Imagine the potential snowball effect that reaching 1 Million people could have. Imagine what would happen if other likeminded doctors and practitioners came together. 1Million would become 2 Million or even 10 Million. The potential is limitless. Evolution from Engineer to Health Advocate & Practitioner Growing up, I always had a keen interest in health and exercise. I was a naturally gifted athlete and always aimed to better myself whether it was on the field or in the gym. I considered myself to be of pristine health while eating according to the still commonly accepted nutrition beliefs supported by dietitians, doctors, the FDA, and various other healthcare advocates and associations. I ate a low fat diet with plenty of whole grains, low calorie diet drinks, and meal replacement bars. And junk food was never even a thought. At the time, I was convinced that I was doing everything right. Instead of following my passion at the time, I pursued an education and career as an engineer, which in hindsight, ended up being one of the best things that could have ever happened to me. I have no doubt in my mind that if I entered the health field as a doctor, physical therapist, or otherwise, I would have ended up accepting and adopting the very same illogical preconceptions about health that I now advocate against. But it didn't happen without consequence. While I continued to live my so-called "healthy" lifestyle, my body began telling me a different story. My energy levels began to drop quickly, my cholesterol was elevated, I began to experience digestive issues, and I always seemed to be suffering from skin issues that wouldn't clear up. I finally came to accept the fact that these symptoms were not a sign of pristine health. Then, by chance, I happened to meet one of the most enlightening and influential people of my life: my wife, Karen. 5 I put up a long and hard fight to hold on to my dogmatic beliefs about health and nutrition. However, in the end, Karen taught me to question everything I believed and not too long after that, the truth had become quite clear. As an engineer, anytime I learned something new, I felt the need to understand exactly how it worked. So, it was second nature to become enthralled in studying and understanding the complexities surrounding nutrition, hormones, the digestive system, other processes of the body, and how they all interacted and worked together. Fueled by my own personal health transformation, I quickly became passionate about what I was learning at the time and found myself connecting with anyone who was willing to listen. It wasn't long after that when I took my work online and began sharing it with a much larger audience. And before I knew it, it caught on quickly and began growing at a faster pace than I had ever imagined. I soon began consulting with people all over the world who wanted to overcome their health problems naturally. Many of which were failed by the conventional medical model. It became quite clear to me that people felt helpless about their health because they didn't understand what was really happening to them. And their doctors and healthcare providers further enabled this feeling by telling them to accept their health problems and learn to live with them the best they could because there was no hope of a full recovery. 6 When you don't understand the problem, then it is impossible to find a solution. I found that when you take a complex health issue and break it down for someone to understand, then it becomes far less intimidating and a lot less stressful. It also becomes logical and easy to see how most health problems can be reversed by simply delivering to your cells what they need to thrive and removing whatever it is that is impairing their health. Seems logical right? At this point in time, it became quite clear to me that I had found my life's legacy. And I continue to build that legacy by sharing with you my own research and my own experiences as well as those of my clients. I have studied and worked with some of the most well respected thyroid researchers, doctors, and practitioners. I have worked through my own trials and errors in correcting my own hypothyroidism as well as with many personal clients. And through my experience, I have created the Hypothyroidism Revolution which is revolutionizing the way the way that the world sees and deals with hypothyroidism by attacking it at the source. Once you wade through the misinformation and poor research, it will become quite obvious that hypothyroidism is grossly under-diagnosed and grossly misunderstood today. It is only a matter of time before hypothyroidism begins to get the full recognition that it deserves and I invite you to join me on the forefront of this movement and to arm yourself with the tools and resources that you need to revolutionize your health and help lead this change that is going to better and save the lives of millions. 7 The Importance of Thyroid Health Your thyroid is well known for playing a crucial role in a number of extremely important processes within your body. For example, you are probably well aware of the role it plays in your metabolism and your ability to lose weight. But that's thinking on a broader superficial level. Let's think for a second on a much deeper level. When it comes to the cells of your body, your thyroid plays the crucial role of regulating the amount of energy that each cell produces. And each cell must maintain a certain level of energy in order to remain healthy. For example, two of the most important organs within your body, your brain and heart, rely heavily on your thyroid in order to maintain their energy and continue to function properly 24/7. But that's just scratching the surface of the importance of your thyroid. It goes far beyond that. Science is now beginning to understand that dozens of disease processes involve cells that are unable to produce energy efficiently as a result of hypothyroidism. This ultimately results in a metabolic defect within your cells which stops your cells from naturally healing and instead promotes unhealthy and damaged cells to divide into new unhealthy cells, which then kick-starts the entire disease process. This process is how the formation of cancer begins and is also common among inflammatory diseases, degenerative diseases, developmental diseases, autoimmunity, immunodeficiency, stress, and even aging. Because this inefficient energy production and metabolic defect are largely caused by your dysfunctional thyroid, it becomes much easier to see and understand how hypothyroidism is involved at some level with all of these diseases, including cancer. So, when it comes to correcting or preventing health problems and disease, a healthy thyroid is essential and far more important than you probably realize. 8 7 Simple Solutions to Hypothyroidism Regardless of what the medical community wants you to believe, there's never one solution to any health problem. If it were as simple as taking one supplement or even medication to solve your problem, then I think that most health problems would be eliminated by now. The sad truth is that most common health problems continue to rise regardless. And hypothyroidism is no different. There are many different factors that affect the health of your thyroid. Even though your hypothyroidism might have been caused by one initial problem (which is rare), that one initial problem quickly creates a domino effect. Before you know it, you could be dealing with a number of problems that all need to be fixed in order to heal your thyroid. For example, let's say that your diet is poor and you're not supplying your liver with the necessary nutrients to convert your thyroid hormone into its active form. This will directly make you hypothyroid because your body is not converting the thyroid hormone into the form that your cells can use. When your liver doesn't get the necessary nutrients that it needs, it also becomes sluggish or congested and doesn't work properly. One of the important roles of the liver is to break down the hormones that need to be excreted from your body, such as estrogen. If your body can't get rid of estrogen then it accumulates and it's very well known that excessive estrogen is a major cause of hypothyroidism. 9 So, your one initial problem quickly becomes two, three, or more that all have to be corrected in order to heal your thyroid and restore your health. Keep this in mind when learning about these 7 Simple Solutions to Hypothyroidism that I've given you below. If you think that one or more don't apply to you, it might apply more than you realize. Solution #1 Balance Your Estrogen Levels Excessive estrogen levels are becoming an epidemic health problem. The vast majority of women today are dealing with major hormonal imbalances centered on having too much estrogen in their bodies and oftentimes not enough progesterone. This is very evident later in life, especially during menopause when progesterone levels naturally drop. Excessive estrogen causes estrogen levels to remain high while progesterone drops quickly which results in the emergence of menopausal symptoms. And estrogen enters your body from many different sources Synthetic Estrogens In Birth Control PhytoEstrogens In Food Estrogenic Environmental Toxins XenoEstrogens In Plastic And the list goes on And if you're a male and you don't think that this applies to you, then I'm sorry to say but you are wrong. Men do naturally have estrogen in their bodies and do accumulate estrogen much the same as women. It is becoming an increasingly common problem for men's health too. Estrogen's role in hypothyroidism has been well documented. Estrogen directly affects the thyroid gland by inhibiting its ability to secrete its thyroid hormone. And if your thyroid can't secrete its hormones, then they oftentimes will build up within the gland. In the end, your body doesn't get the thyroid hormone it needs and you quickly become hypothyroid. This is also why estrogen plays a significant role in both Hashimoto's Thyroiditis and goiters. So, if you are dealing with either one of these issues then it's imperative that you work on regulating your estrogen levels in order to truly heal your thyroid. 10 What You Can Do To Balance Your Estrogen Levels For starters, one of the best ways is to avoid them. While you can't avoid the estrogen that your body naturally produces, you can do your part to avoid the ones that you're absorbing through outside sources. Choose a safer (for your health), form of birth control. But be careful and educate yourself because even non-hormonal birth control methods can still affect your hormones. An Intrauterine Device (IUD), for example, has been shown to decrease progesterone production which effectively leads to excessive estrogen. Remove estrogen promoting foods from your diet. Most notably soy and soy products. Remove or limit estrogenic environmental chemicals such as herbicides, fungicides, and pesticides by eating organic foods. Remove or limit your exposure to XenoEstrogens in plastic by using non-toxic alternatives, such as glass, whenever possible. And avoid heating anything in plastic that will come into contact with your body, especially food. Of course, limiting outside sources of estrogen is great, but what about the excessive estrogen that's already in your body? This is a very in depth topic that entire books could easily be written about. So, while I can't get into every aspect of properly decreasing and detoxifying estrogen from your body, I can give you a neat trick. While some foods promote estrogen, there are some foods that actually help reduce estrogen in your body. One such food is carrots. Carrots, when eaten raw, will act like charcoal within the intestines and absorb estrogen within your digestive tract. This prevents your body from re- absorbing it. Here's a great recipe that you can make daily to help lower your estrogen and stress hormones while increasing your thyroid and progesterone to improve overall hormone balance. 11 Raw Carrot Salad Note: this should be eaten alone in order to prevent the carrot from blocking the absorption of other vital nutrients. 2 medium sized carrots 1 Tbsp of coconut oil 1 Tbsp of olive oil 1 to 2 Tbsp of raw apple cider vinegar Salt Shred carrots and add coconut oil, olive oil, and apple cider vinegar. Mix together and salt to taste. Solution #2 Manage Your Stress Hormones Let's face it. Stress is everywhere and it can come at you in any form. It doesn't matter if you missed a work deadline or you're running for your life from a bear. Stress is stress. And your body reacts to stress the same no matter what the source. That is by pumping out stress hormones in order to help you deal with the stress until the stress is over. The problem with stress today is that it never stops. We live in a society where chronic stress is the norm and unfortunately, it's taking its toll on your thyroid and your health. There are many sources of stress that most people fail to consider Psychological Stress Dietary Stress Environmental Stress Physical Stress 12 Stress has some pretty nasty effects on your hormones and your body. With respect to your thyroid, the stress hormones (adrenaline and cortisol) that your body produces actually inhibit the conversion of your non-active thyroid hormone (T4) to your active thyroid hormone (T3). It also increases your production of a hormone called Reverse T3 (rT3), which blocks your body from properly using your thyroid hormone. Both of these effects cause hypothyroidism. It's also worth noting that your body does this for a reason and it's not just to punish you. When under stress, your body naturally down regulates your thyroid because all it cares about is conserving energy. It does this as a survival mechanism so that you can conserve enough energy to outlast the stress. Another problem with the stress hormone adrenaline is that it forces your body to increase the concentration of free fatty acids in your bloodstream. Because most people have large concentrations of polyunsaturated fats in their fat cells, when these fats are forced into your bloodstream they block your thyroid hormone from reaching your cells. And those are just a couple of examples of how stress causes hypothyroidism. There are also a large number of other negative effects that are caused by an over- production of stress hormones as well including Osteoporosis Damage to brain cells Accumulation of fat, especially on the back and abdomen. Damage to blood vessels Aging of the skin Damage to your immune system Damage to your nerve cells What You Can Do To Reduce Your Stress Hormones First, the most obvious answer is to reduce as much outside stress as possible. You can't eliminate all outside stress, but you can do a lot to minimize it. I recommend that you pinpoint your greatest source of stress and then brainstorm what you can do to help minimize that stress. Work on each source one at a time. And don't push yourself too hard. In our society, more is always better, but sometimes you have to stop, rest, and smell the roses. 13 Another rather simple and immediate way to reduce your stress hormones that most people don't know about is to balance your blood sugar levels. One of the roles of the stress hormone, cortisol, is to break down protein in order to raise your blood sugar when it drops too low. By balancing your blood sugar and maintaining that balance, you can not only keep your stress hormones at bay, but you can also help keep free fatty acids out of your bloodstream to help boost your thyroid function and metabolism. Lastly, it's important to balance your sodium levels. When you're hypothyroid, then you lose sodium easily. Low sodium levels drive adrenaline up. So, adding enough salt to your diet is a very important and overlooked part of the puzzle. Solution #3 Restore Your Liver Function I have already mentioned this previously but here I will go into a little more detail. It is important to understand that this is a major problem that you must correct to overcome hypothyroidism. Your thyroid gland produces mostly the non- active thyroid hormone (T4) and a little bit of the active thyroid hormone (T3), which your body can use immediately. But 2/3 of the active thyroid hormone that your body uses is converted from T4 by your liver. So, if your liver is congested then it can't convert these hormones and you quickly become hypothyroid. But that's not the only problem. Because your liver can't convert it, the T4 tends to accumulate in your body. This build up of T4 works against your thyroid as well because your body sees it and tells your thyroid to slow down and stop producing so much thyroid hormone which pushes you further into hypothyroidism. Another problem that occurs with a congested liver is that your liver loses its ability to properly store sugar. It is this stored sugar in your liver that plays an important role in helping you to maintain steady blood sugar levels throughout your day. When your liver can't store sugar, your blood sugar levels tend to fall, which puts your body immediately into a stressed state. And this kick-starts the whole stress hormone reactions that I just discussed above which you now know, also leads to hypothyroidism. 14 What You Can Do To Get Your Liver Healthy One important factor in keeping your liver healthy is to give it a break so that it doesn't have to work so hard. You can do this by reducing your exposure to toxins and keeping your hormones in balance so that your liver isn't working overtime detoxifying everything. Another important thing that is absolutely necessary is to make sure that your liver has access to all of the necessary nutrients that it needs to both function and convert your thyroid hormone to its active form. This includes giving it the right kinds and right amounts of sugar as well as the right minerals, such as selenium. Solution #4 Eat the Right Proteins The general public is finally starting to catch on to the fact that protein is a very important part of your diet. However, what is not well understood by most is that the quality of the protein is also extremely important. Most people are eating far too many poor protein sources such as Soy protein Whey protein Rice Protein Pea Protein And other forms of processed proteins and isolates Yes, I understand that whey protein is very widely used but that doesn't make it healthy. Whey is high in a certain amino acid, which is not only inflammatory, but also leads to a series of reactions within the body that suppress your thyroid. Also, a lack of protein in your diet leads to an increase in the stress hormone, cortisol. And your cortisol levels rise when there is a protein deficiency because one of its roles is to break down muscle tissue to supply your body with the necessary protein that it needs if it is lacking in your diet. As I mentioned previously, your stress hormones inhibit the conversion of your thyroid hormone to its active form. It also blocks your body from being able to properly use the thyroid hormone. Both of these lead to hypothyroidism. It's also worth noting that a lack of protein can also cause you to not respond to thyroid supplements. 15 What You Can Do To Avoid Protein Deficiency The first thing you can do is to be sure to get at least 70 to 100 grams of high quality protein per day. This is enough to ensure that your body has enough protein available and to avoid the added stress of having to break down your own muscle tissue. You also want to make sure that you are getting high quality protein. And it will probably come as a surprise but one of the best sources of protein you can get is from bone broth. It is very anti-inflammatory and contains a very healthy mix of amino acids. It is the mix of these amino acids that make bone broth great for helping you to overcome hypothyroidism. There are plenty of great bone broth recipes that you can easily find online. Solution #5 Balance Your Blood Sugar I touched on blood sugar problems earlier when talking about both stress and liver congestion. So, hopefully you're beginning to see how all of these causes promote each other which can really cause a domino effect for your hypothyroidism. But as a quick reminder, low blood sugar both decreases the conversion of T4 to active T3 in your liver and it signals your body to increase production of the stress hormone, cortisol, which breaks down your muscle tissue in order to keep your blood sugar from dropping to dangerously low levels. What You Can Do To Balance Your Blood Sugar One easy and healthy way to maintain your blood sugar levels is to eat plenty of fully ripened fruit. It is naturally high in potassium, which helps to regulate your blood sugar by reducing the amount of insulin that your body needs to properly absorb the sugar. In fact, the sugar from fruit is a powerful blood sugar regulator. This is because it has the unique ability to either increase or decrease your blood sugar levels depending on what your body needs at the time. It also reduces your tendency to store fat as an added bonus. 16 This is different than some other forms of sugar which cause your blood sugar to rise rapidly. The wrong sugars cause your body to secrete a large amount of the hormone insulin, which helps to remove the sugar from your bloodstream. But at the end of this process, your blood sugar typically drops too low once again re-starting the cycle. Another important factor in managing your blood sugar levels is to cut out polyunsaturated fats from your diet. These fats can lead to insulin sensitivity and eventually, diabetes. But I will discuss this in more detail in a minute. One other useful tip worth sharing is that many people need to eat something before they go to bed in order to help them maintain their blood sugar level throughout the night. In fact, low blood sugar is an extremely common cause of night waking and insomnia. This is because when blood sugar is low, stress hormones rise. Oftentimes, adrenaline rises high enough to wake you up. This is especially important with hypothyroidism when your liver can't properly store the sugar that it would normally use to keep your blood sugar balanced throughout the night. And as you should now know, with low blood sugar comes high stress hormones, which again, causes hypothyroidism. Solution #6 Avoid Polyunsaturated Fats This is a big one that most people are not aware of and that's because it's more of a controversial topic that really deserves a lot more attention than it gets. But when you really look at it from all angles, I think the research speaks for itself. Studies have linked polyunsaturated fats in your diet to numerous diseases including diabetes, cancer, heart disease, and obesity just to name a few. A big part of the problem with these fats is that they have such a long lasting effect on your body once they become stored in your fat cells. Even if you remove them entirely from your diet, they can still be present within your body for up to 4 years while continuing to cause damage. Part of the problem of these types of fats is that they are highly unstable, especially when under heat and in the presence of oxygen. They become very reactive within your body when you eat them because they are heated to your body temperature and mixed with the abundance of oxygen within your body. So, they easily become rancid and toxic both inside and outside of your body. 17 Another major problem is that they are heavily involved in the production of free radicals within your body, which is another major factor in cell damage and disease. This is why antioxidants are so important because they help slow free radical damage. When it comes to your thyroid, polyunsaturated fats have a direct effect on blocking your thyroid and decreasing your metabolism on multiple levels. For starters, these fats block the enzymes that signal your thyroid gland to release its hormones. This limits the amount of thyroid hormone available to your body. When these fats enter your bloodstream, they also block the active thyroid hormone within your bloodstream from being transported to the cells that desperately need it. Lastly, they block your cells from properly responding to the thyroid hormone that they do get which makes the hormone much less effective to your cells. So, as you can see, polyunsaturated fats are a major cause of hypothyroidism. What You Can Do To Reduce the Effects of Polyunsaturated Fats First of all, polyunsaturated fats are used everywhere. That is because they are extremely cheap to manufacture. So, you can bet that pretty much all restaurants that you eat at are cooking your food in polyunsaturated fats. Here's a list of polyunsaturated fats that you should remove from your diet Vegetable Oil Soybean Oil Corn Oil Safflower Oil Canola Oil Sesame Oil Sunflower Seed Oil Flax Oil Peanut Oil Cotton Seed Oil Almond Oil And any other oil that is labeled as unsaturated or polyunsaturated Instead, the fats in your diet should be focused around Coconut Oil Butter 18 These saturated fats have enormous health benefits, including helping to cancel out the negative effects of those nasty polyunsaturated fats. They promote healthy thyroid function and increase your cells response to thyroid hormone. And there's no reason to be afraid of these fats just because they are saturated. Those claims against saturated fats are completely lacking in research and provide no substantial proof of any of the negative claims. However, there is plenty of research that shows that these fats inhibit inflammation, promote weight loss, protect against cancer, and naturally help to lower cholesterol. Solution #7 Stop Over-Exercising Let's get something straight right away. You don't have to be overweight to be hypothyroid. There are a lot of people who are hypothyroid and who are skinny. So, keep that in mind that weight alone is not the only indicator of hypothyroidism. You would probably be surprised to find out how many professional athletes are really hypothyroid from all of the physical stress that they place on their bodies. But we often look at these athletes as the perfect image of health. However, their hormones are telling a very different story. Over-exercising is a very common problem with hypothyroidism because most people get into the mindset that if they aren't losing weight or if they have low energy, that they just need to push themselves harder. Maybe you've been there before? If you did happen to lose weight, then your energy levels most likely plummeted while your body began to fall apart. This is because too much exercise or the wrong kind of exercise only makes you more hypothyroid. For starters, intense exercise requires your body to use up a lot of sugar very quickly. As I mentioned before, if your liver can't properly store sugar then you won't have any fuel in your tank. So, your body will have no other choice but to increase stress hormones to break down your muscle tissue to use as energy. In the end, you're left with less muscle and more fat, especially around your abdomen. 19 Also, speaking of stress hormones, when those hormones rise, they cause more and more of those nasty polyunsaturated fats that we just talked about to enter your bloodstream. And as you already know, this also has a major hypothyroid effect. Some studies on exercise have even showed that over-exercising can stop your body from producing the active thyroid hormone immediately and continue to inhibit your thyroid function long after your workout is finished. So, if your plan is to work out harder or even hard at all, then you might want to reconsider whether or not that is the best choice for you and your health. What You Can Do To Prevent Over-Exercising Keep in mind that not all exercise is bad. In fact, there are some extremely beneficial forms of exercise for hypothyroidism that are just not intense and stressful to your body and thyroid. Instead, they naturally promote your thyroid and your body's hormonal health. One great example of probably the best form of exercise for hypothyroidism is Tai Chi. There is a very good reason that Tai Chi is known for its revitalizing effects. In fact, in America, Tai Chi has gained a lot of popularity within the elderly community because it has been proven to greatly improve their quality of life. Another common mistake is performing intense exercise in the early morning, which should be avoided. Also, never exercise on an empty stomach. Your stress hormones are highest overnight and continue to remain high in the early morning. So, exercising at this time only causes them to rise even higher and for longer periods of time. Eating breakfast in the morning and balancing your blood sugar is typically when your stress hormones return to normal. So, exercising on an empty stomach is yet another way to keep your stress hormones high. And it doesn't matter what time of the day you workout. If your stomach is empty and your blood sugar is low then your body will respond in the same way, with a rise in stress hormones. 20 Closing Thoughts on Hypothyroidism Well, I hope you learned a few things by reading this report. I've given you 7 Simple Solution to Hypothyroidism including some great tips that you can start using today to address these problems and finally start correcting your hypothyroidism. Do keep in mind that there is no quick fix or magic potion. If you truly want to beat hypothyroidism, then you have to correct the underlying cause. This can be a bumpy ride as you figure out what works for you and what doesn't. So, don't be discourage and understand that it's part of the natural process that happens with everyone. In the end, you will be happy that you did because the results are amazing. I know that a lot of this is probably very new to you. A lot of it might even contradict things that you have been told in the past. But until we start making some big changes with the way we deal with hypothyroidism and our health, don't expect to see much, if any, change in our incidence of disease. That is why it's time for a revolutionary shift in our mindset when it comes to our health. I strongly encourage you to start incorporating all 7 Simple Solutions to Hypothyroidism into your life and start experiencing some of the results for yourself. You'll be one step closer to overcoming your hypothyroidism and getting the life that you deserve back. Where To Go From Here? Hopefully by now you realize and understand the importance of reversing your hypothyroidism in order to prevent or reverse the vast number of common health problems and diseases related to hypothyroidism. In my personal experience and my experience in working with clients, correcting hypothyroidism needs to be your #1 priority because, if your cells are not getting the nutrients and hormones that they need to be healthy, your body will never truly heal. Because almost all of the information available today on hypothyroidism is either outdated or just flat out incorrect, I've decided to share everything that I have learned with you. Trust me when I say that this report is only the tip of the iceberg. 21 Month's Of Sweat, Hard Work, and Dedication I've literally spent months and months taking what I do and breaking it down into a simple to understand and implement 3 Step Hypothyroidism Treatment Process that works every single time with my clients. These 3 Steps are literally the missing keys to the hypothyroidism puzzle that everyone else is missing. If you miss any one of these steps then it simply does not work. Why are these 3 Steps so effective? Simply put When you go directly to the source and correct the underlying causes of your hypothyroidism then there's nothing left to continue holding your thyroid hostage and your thyroid can finally heal. I've created a free presentation for you where I explain exactly what this 3 Step Hypothyroidism Treatment Process is and how you can use it to naturally and permanently get your life back by stopping hypothyroidism at the source Click Here to Watch Your Free Presentation Giving You My Exact 3 Step Hypothyroidism Treatment Process CLICK HERE Get AMERICAN NATURAL SUPERFOOD Today for FREE Just Cover Shipping & Handling No Membership or Autoship! Curcumin The 21st Century Cure Jan McBarron, M.D., N.D. OPTIMAL BODY DEFENSE David Lyons with Arnold Schwarzenegger Fight Back Against Excess Inflammation Contents CHAPTER 1: What Is Curcumin and How Does It Work?, 1 CHAPTER 2: Curcumin and Heart Disease, 7 CHAPTER 3: Curcumin and Cancer, 12 CHAPTER 4: Curcumin, Chronic Pain and Arthritis, 17 CHAPTER 5: Curcumin and Diabetes, 21 CHAPTER 6: Curcumin and Memory: Alzheimer's and Dementia, 26 CHAPTER 7: Curcumin, Depression and Other Brain Disorders, 35 CHAPTER 8: Curcumin and Digestive Disorders, 40 CHAPTER 9: Curcumin and Other Diseases, 43 Scientifically Validated Curcumin, 47 References, 47 About the Author, 50 C H A P T E R 1 What Is Curcumin and How Does It Work? AN ASIAN SECRET FOR LONGEVITY What if I told you there is a common spice that can give you the gift of a long and healthy life? How about an extract of this familiar spice that can prevent and even cure heart disease, can- cer, diabetes, Alzheimer's disease, depression, joint pain and more? Maybe you would think it's just a bunch of hype, but I can assure you there is voluminous scientific research that warrants placing curcumin at the pinnacle of all healing herbs. If you love curry, you'll be familiar with turmeric, a popular vividly-colored spice. Inside turmeric is a compound called cur- cumin, which is found in its rhizome (the stem of the plant found underground). Curcumin is responsible for the golden orange color of turmeric, and is perhaps the most powerful botanical medicine in the world today. However, there is very little curcumin in the spice turmeric. If you've seen cheap turmeric supplements on the market, understand that they only contain 2 to 5% curcumin, which may or may not be usable by your body, and they're not likely to have any effectiveness in terms of prevention or treatment for the diseases we're talking about. Curcumin is many times more powerful than turmeric. For centuries, curcumin has given the gift of long life and robust health to the people of India, for whom various types of curriesalways made with turmericare a dietary staple. 1 Curcumin is an important ingredient in the Ayurvedic medicine tradition and a vital part of Traditional Chinese Medicine. Now I can say without equivocation that it is the cure-all of the 21st century, backed by voluminous research that credits its healing powers to its exceptional antioxidant and anti-inflammatory properties. Botanically known as Curcuma longa, the turmeric rhizome is a member of the antioxidant-rich ginger family. You might be understandably skeptical when you hear that this humble Indian spice can prevent, treat and cure a wide variety of serious diseases. These include everything from heart attacks to a dozen types of cancer, the pain of all types of arthritis and even "incurable" dis- eases like diabetes and Alzheimer's. Curcumin also soothes depres- sion and the agony of a variety of digestive disorders, including Crohn's disease, inflammatory bowel disease and irritable bowel syndrome. 2 r CURCUMINTHE 21ST CENTURY CURE In this book, I'll address your skepticism with an in-depth examination of each of these conditions and the research support- ing curcumin's role in prevention, treatment and cure. CURCUMIN: THE TRIPLE WHAMMY AGAINST CHRONIC DISEASE Curcumin has proven antioxidant, anti-inflammatory and anti- cancer properties. This takes in most, if not all, of the chronic dis- eases of aging known to modern science. Think about rust on the bumper of a car. Rust is caused by oxi- dation or damaging oxygen molecules that corrode and eventually destroy the structure of metal. Those same corrosive oxygen molecules (sometimes called free radicals) are found inside the human body, and while they are part of the aging process, they are an unpleasant part of it because they contribute to the deterioration of cells. When these "rusty" cells reproduce, each generation is just a little different from the last and a little bit less able to perform its function properly. That, in a nut- shell, is how and why we age. The oxidative aging process is escalated by environmental factors: Polluted air and water Plastics and other toxic materials that contaminate nearly every- thing we touch, eat and drink Pesticides and other poisons and hormones in our food and even in our clothing Processed foods, smoking, obesity, lack of exercise and other unhealthy lifestyle choices OXIDATION AND INFLAMMATION CAUSE DISEASE So, what happens when we get "rust" or oxidative damage in our cells? Our brain cells begin to deteriorate, so memory becomes WHAT IS CURCUMIN AND HOW DOES IT WORK? r 3 fuzzy; our hearts don't beat as efficiently as they once did; our arteries become clogged; our blood sugars spike and cellular divi- sion is thrown so far out of whack that our cells begin to divide wildly, creating cancers that can kill us. This oxidative stress can also cause brain chemistry to mal- function, resulting in depression, one of the most common and debilitating diseases of modern times. Worst of all, these nasty free radical oxygen molecules cause inflammation, with obvious results if you think of arthritis, joint pain and other forms of chronic pain, but less obvious ones as under - lying causes of all of the degenerative diseases already mentioned. In addition, obesity and inflammation go hand-in-hand. Most likely, obesity causes inflammation, although the scientific commu- nity isn't quite convinced yet. More than 40% of all Americans are obese. When we add in those 30% who are overweight but not yet obese, we find that excess weight plagues 70% of all American adults. That makes the inflammation associated with obesity a seri- ous contributing factor in all of the diseases of aging. THE GOLDEN KNIGHT Like a golden knight on a palomino charger, curcumin rides to the rescue! Curcumin is by far the most powerful antioxidant known to science, hundreds of times more powerful than blueberries, which have substantial antioxidant capabilities themselves. A handful of devastating diseases of aging are all partially or totally caused by oxidation: ! Heart disease ! Osteoarthritis ! Cancer ! Alzheimer's disease ! Diabetes ! Dementia 4 r CURCUMINTHE 21ST CENTURY CURE On the ORAC (Oxygen Radical Absorbance Capacity) scale that rates the antioxidant power of foods, only BCM-95 Cur- cumin rates over 1.5 million per 100 grams, while antioxidant- rich blueberries have only a 6,000 ORAC rating per 100 grams! This means that just one high-quality curcumin capsule delivers more than 25 times the antioxidants as the same amount of blue- berries. Curcumin literally scrubs the oxidative "rust" from your cells, preventing serious disease and reversing diseases you may already have. It helps stop cell deterioration and restores the cellular genet- ic codes to youthful levels, ensuring those cells will reproduce more like they did when you were young. More important, from the viewpoint of damaged cell division found in cancer, curcumin also tells these cells to die when their time comes, as ordained by nature, which stops tumor growth. And that wonderful yellow curcumin stops inflammation and all of its obvious and not-so-obvious damaging effects, relieving inflammatory problems like arthritis and joint pain and eliminat- ing the building blocks for heart disease, diabetes and other diseases that have a foundation in chronic inflammation. In addition, curcumin has a unique ability to cross the blood- brain barrier, a membrane that protects the brain from invaders like bacterial infections and keeps out most other substances as well, including those that might be helpful. This gives curcumin the ability to deliver its antioxidants and anti-inflammatories directly to the brain, which is particularly helpful in cases of dementia and depression. In the case of cancer, cutting-edge research shows curcumin has a variety of ways of stopping abnormal cell growth, including an ability to affect cell division on the genetic level. If that's not enough, studies also show that curcumin protects the liver and kidneys. Curcumin has been compared to pharmaceutical drugs for the treatment of a wide variety of diseases, and it has come out on top in every case. WHAT IS CURCUMIN AND HOW DOES IT WORK? r 5 ANOTHER TRIPLE WHAMMY AGAINST INFLAMMATION Inflammation is a factor in 80 to 90% of all disease, according to curcumin researcher Ajay Goel, Ph.D., director of Epigenetics and Cancer Prevention at Baylor University Medical Center in Dallas. What's not to love? "Curcumin demonstrates superior antioxidant and anti-inflam- matory effects and provides liver- and heart-protective benefits as well. It is a potent antibacterial, antifungal, antiviral, anti-allergenic and has antitumor and anti-cancer properties," says Dr. Goel. By knocking out viruses, bacteria and fungi, curcumin offers the powerful possibility that we can use it to treat everything from colds and flu to pneumonia or even to help with something as seri- ous as AIDS or cancer, effectively and without dangerous side effects. 6 r CURCUMINTHE 21ST CENTURY CURE C H A P T E R 2 Curcumin and Heart Disease Since heart disease is the #1 killer in the Western world, any nutrient, like curcumin, that helps protect your heart and arter- ies and even reverses heart disease should be most welcome. Curcumin's heart-protective effects become even more impor- tant when we add diabetes to the mix. Heart disease is the most common complication of diabetes, and the number of newly diag- nosed diabetics is increasing dramatically every year, with nearly 2 million new cases reported among U.S. adults in 2010. KEEP ARTERIES CLEAR Clogged arteries raise the risk of heart attack and stroke. Fatty deposits (called plaque) cause arteries to narrow, reduce blood flow, make your heart work harder to move blood through the circula- tory system and harden the arteries. In time, cholesterol buildup can completely block an artery and cause a heart attack or stroke. Curcumin raises the levels of HDL or "good" cholesterol that helps move fats out of the cells, including the cells in the arteries. It also reduces the stickiness of blood cells, preventing clots. With curcumin, cholesterol improvement can happen fast: An Indian study showed that human volunteers who took 500 mil- ligrams a day for just a week increased their good (HDL) choles- terol by 29%. 7 In addition, inflammation is a foundational cause of cardio- vascular disease and there is abundant evidence that curcumin is one of the most potent anti-inflammatory substances known to science. Therefore, it stands to reason that reduction of inflam- mation also reduces the risk of heart disease and stroke. Other studies suggest that curcumin may actually change the messages sent by genes that signal the body to build up those fatty deposits in the arteries. Image of arteries shows normal flow (top), constricted flow (center) and blocked artery (bottom). 8 r CURCUMINTHE 21ST CENTURY CURE REDUCE HOMOCYSTEINE AND CRP LEVELS Homocysteine is an amino acid naturally present in the human body. When homocysteine starts to build up in the bloodstream, it increases the hardening and narrowing of the arteries, may cause blood clotting, raises your risk of heart disease and can be predic- tive of a heart attack, stroke and possibly Alzheimer's disease. CRP (C-Reactive Protein) is a body signal of inflammation. It damages the arterial walls, resulting in hardening of the arteries and blood clotting. Curcumin helps to relax those arterial wall cells, reduces the hardening of the arteries and allows the blood to flow more freely, dissolving clots and preventing and even revers- ing plaque buildup. REVERSE HEART FAILURE Congestive heart failure occurs when the heart can no longer pump enough blood to the rest of the body. It is usually a slow process that gets worse over time. As the heart muscle loses its abil- ity to pump oxygen-rich blood throughout the body, it causes fluid buildup in the lungs, liver, gastrointestinal tract, arms and legs. This lack of oxygen damages vital organs, eventually causing death. Curcumin prevents the creation of scar tissue in the heart mus- cle and helps failing hearts return to their normal pumping capac- ity, according to breakthrough Canadian research published in 2008. Scientists at the Canadian Institutes of Health Research dis- covered that curcumin acts directly on the DNA of heart cells, pre- venting them from unraveling under physical stress. Curcumin was shown to switch off the "unraveling switch" in the heart cell DNA that keeps scar tissue from developing. In the February 2008 edition of the Journal of Clinical Investi- gation, researchers at the Peter Munk Cardiac Centre of the Toron- to General Hospital reported that curcumin may dramatically reduce the chance of developing heart failure. CURCUMIN AND HEART DISEASE r 9 "When the herb is given orally, it can actually prevent and reverse hypertrophy, restore heart function and reduce scar forma- tion," researchers wrote. PREVENT STROKE AND STOP STROKE DAMAGE Strokes have two major causes. The most common is a blood clot that travels to the brain and the second is a ruptured blood vessel in the brain. As we learned earlier in this chapter, the buildup of cholesterol, elevated homocysteine and CRP levels and even con- gestive heart failure are risk factors for stroke as well as heart attack. Since stroke is a cardiovascular disease, a stroke is a "brain attack," if you will, similar to a heart attack. We already know that curcumin has powerful preventive and healing properties for all of these conditions. Strokes almost inevitably damage brain cells. But exciting new research shows that curcumin, given intravenously, can minimize brain damage while a stroke is in progress because it can cross the blood-brain barrier, protecting the mechanisms that help regener- ate brain cells. This is effective if it is administered in an emergency room within three hours of a stroke. SUPER ANTIOXIDANT Curcumin's antioxidant properties are one of its most potent weapons against all of the diseases commonly linked with the aging process, most notably cardiovascular disease. I like to think of antioxidants as "rust removers" of the body because they literally remove the "rust" or the foundational causes of the diseases of aging connected to excessive free-radical oxygen molecules. Cholesterol or even excessive cholesterol in itself does not clog arteries. It is the oxidized cholesterol that clogs arteries, restricts blood flow to vital organs and eventually breaks away to cause heart attacks and strokes. 10 r CURCUMINTHE 21ST CENTURY CURE By preventing this oxidation in the first place, curcumin's antioxidant properties keep the arteries clear of that potentially fatal oxidized cholesterol or plaque. CONCLUSION Curcumin's abilities to protect your heart, brain and cardiovascu- lar system are beyond impressive. Consider the drugs commonly used to treat the heart conditions discussed in this chapter. The statin drugs alone (Lipitor, Crestor and their cousins) carry with them huge health risks from side effects, including causing death from sudden heart failure. It only makes sense to use substances that are effective as well as harmless. Curcumin is natural and safe. Only rarely do people taking cur- cumin get mild stomach upset at dosages of 10 grams per day or more. What's more, even the highest quality products are very affordable. Who could ask for more? CURCUMIN AND HEART DISEASE r 11 C H A P T E R 3 Curcumin and Cancer 12 Cancer arouses more fear in the human heart than any other dis- ease. The dread is well placed, even though cancer is not the #1 killer in the Western world. Every year, more than 1.5 million people are diagnosed with cancer, not including skin cancers, which are by far the most com- mon cancers. Skin cancers afflict 2 million more people every year. Each year, 569,000 of us will die of cancer. There is probably not a single one of us who doesn't know someone who has had cancer and who has personally been touched by the pain and suffering of this dreaded disease. It is not the purpose of this small book to detail the various types of cancer and the death tolls they exact, but let it suffice to say that lung, colon, prostate and breast cancers kill more Ameri- cans than any other forms. While most of us think that cancer is an inherited disease, sci- ence shows us that fewer than 2% of all cancer is related to genet- ics (broken or mutated genes). That means 98% of cancer is caused by something else. That "something else" has opened a whole new science called epigenetics, meaning literally "above genetics." The good news is that we have far more control over our epi- genetics than genetics. Renowned scientist Ajay Goel, Ph.D., of the Gastrointestinal Cancer Research Laboratory at the Baylor Research Institute at Dallas, is at the forefront of epigenetic research. He explains a complex science in simple terms: "Everything we do from the day we are born, everything we eat, drink and are exposed to in our environment has an indirect but strong influence on our genetics. As we age and grow, it is very natural that some of the genes tend to get turned off as a consequence of our eating habits, exercise regimens and exposure to toxic environmental stresses. Doing the right thing in this regard can help us keep our genes healthy." So, when we don't eat correctly or exercise and are exposed to toxins, damage to genes takes place and disease occurs. "Fortunately, unlike genetic defects, epigenetic alterations have a unique characteristic that these changes are reversible," says Dr. Goel. "In other words, although we can do nothing if we are born with a defective gene, it is certainly within our reach to keep our genomes healthy and we can even reverse some of the epigenetic changes by eating right and with regular consumption of health- promoting natural dietary botanicals and herbals," he explains. Here's where curcumin comes into the cancer picture. "Every cell in our bodies has a finite life span," says Dr. Goel. "We have genes in our bodies that govern this natural process of cell death. But sometimes those genes go into a deep slumber, allow- ing cells to continue to live and reproduce long beyond their time, creating cancerous tumors." Curcumin has been scientifically proven to actually "wake up" those sleeping genes, telling cancer cells it is time to die and stop- ping the growth of cancerous tumors. Dr. Goel and his team have produced ground-breaking research that promises to change the way we think about cancer and how it is treatedand curcumin certainly has a strong role in this change. It almost goes without saying that the anti-inflammatory and antioxidant powers of curcumin are the foundation of its ability to prevent and treat cancer, since cancer is caused by inflamma- CURCUMIN AND CANCER r 13 tion and by oxidative stress, meaning, among other things, that DNA has been damaged, impairing the ability of cells to repro- duce perfectly. The staid and highly respected MD Anderson Can- cer Center has expressed un - characteristic enthusiasm about curcumin's anticancer proper- ties in a 2003 statement by researchers published in the journal Anticancer Research: "Extensive research over the last 50 years has indicated it can prevent and treat cancer . . . Curcumin can suppress tumor initiation, promotion and metastasis." Let's take a look at the large body of research that proves curcumin's effective- ness at preventing and fighting cancer: Blocks carcinogenic substances: We're all exposed to carcinogens on a daily basis from auto exhausts, air pollution, food packaging, pesticides and a broad spectrum of substances with which we can- not avoid contact. Curcumin apparently blocks those carcinogens, preventing them from causing the cellular damage that ultimately results in cancer. Stops invasion: Cancer cells invade normal tissue with the help of certain enzymes called matrix metalloproteinase. Cur cumin slows or stops the activity of this enzyme, helping halt the spread of can- cerous cells. Cuts off tumor blood supply: Invasive tumors are fed by their own specially developed network of blood vessels through a process 14 r CURCUMINTHE 21ST CENTURY CURE Breast cancer cells. called angio genesis. Curcumin slows the ability of these tumors to create their blood supply, eventually starving and killing the abnor- mal clusters of cells. Convinces cancerous cells to die: As Dr. Goel points out, "sleeping genes" interfere with the cancer cells' natural life and death cycle called apoptosis. Cancer cells quite literally turn off the signal that it is time to die. Curcumin actually turns on that signal, telling the cancer cells to die, so the tumors eventually die, too. Dr. Goel is cur- rently engaged in more research on the sleeping gene mechanism. These are the basic ways that curcumin works to prevent and stop cancer. There are literally dozens of studies that show cur- cumin's effectiveness against specific types of cancer. Here's a list of types of cancer for which curcumin has been sci- entifically validated as a preventive or treatment: Breast Head and neck Oral Cervical Leukemia Ovarian Colorectal Lung Prostate Gastrointestinal Lymphoma Sarcoma Genitourinary Melanoma Squamous cell As a final word, even the famed Sloan-Kettering Cancer Center is on the curcumin bandwagon, endorsing an anticancer cocktail mixed with another known cancer preventive, green tea. As yet unpublished animal studies show strong evidence that curcumin, administered in tandem with more traditional anticancer drugs, reduces the toxicity of those drugs and improves their effec- tiveness. Three human studies are now underway combining cur- cumin with certain types of chemotherapy drugs commonly used to treat breast and colon cancers. I'm eagerly awaiting more informa- tion on this exciting development. However, there have been sever- al promising studies on the ability of curcumin to improve the effectiveness of many types of chemo and radiation therapy by CURCUMIN AND CANCER r 15 making the cancer cells more sensitive to these treatments. How ever, please discuss with your integrative health professional how best to use curcumin if you are currently undergoing cancer treatment. CONCLUSION While the scientific evidence in favor of curcumin for all of the dis- eases mentioned in this book is impressive, the quality of proof that curcumin prevents and treats a wide variety of cancer is truly excep- tional. Cancer prevention alone should be a sufficient incentive to include curcumin in your daily supplement regimen. 16 r CURCUMINTHE 21ST CENTURY CURE C H A P T E R 4 Curcumin, Chronic Pain and Arthritis V irtually all of us experience occasional joint and back pain. With luck, it goes away with time, rest and perhaps an occa- sional ice pack. Sometimes it does not. Each year, about 30 million of us visit a doctor complaining of joint pain. Another 40 million or so visit a doctor looking for relief from back pain. Add in 1.5 million people with rheumatoid arthri- tis, 6.1 million with gout, 5 million with fibromyalgia and 1.5 mil- lion broken bones suffered every year by people with osteoporosis and you'll see the magnitude of this painful problem. Long-term musculoskeletal pain affects your entire being. It drains your energy and contributes to chronic stress, a condition that has myriad negative side effects, including obesity, metabolic disorders, heart disease and perhaps even cancer. Chronic pain is often linked with depression. Who wouldn't be depressed in the face of unrelenting pain? Joint pain and back pain are most often caused by deterioration of the cartilage that cushion joints (including the spaces between the vertebrae, causing back pain), causing bone to rub against bone and resulting in inflammation and pain. This can be caused by an injury, but most often, it is the result of 40, 50, 60 years or more of wear and tear on the joints. For most of us, our first remedy is to reach for aspirin, ibupro- fen or naproxen. That can be a fatal mistake. NSAIDs (non- steroidal anti-inflammatory drugs) like aspirin, ibuprofen and 17 naproxen plus a handful of prescription drugs like Celebrex, Anaprox, Feldene and Voltaren can cause serious toxicity problems that require hospitalization for as many as 200,000 Americans each year and kill over 20,000 people annually. Yet 60 million of us use them regularly and doctors still happily prescribe them. Exciting new human research confirms that curcumin is as effective as some of the most popular non-steroidal anti-inflamma- tory (NSAID) arthritis drugs, including Voltaren and Celebrex, without the potentially life-threatening side effects. A combination formula of BCM-95 Curcumin and a special form of the herb boswellia called BosPure was found to be more effective in pain relief and provided better mobility and longer walking times with- out pain for people with knee osteoarthritis, than the prescription drug celecoxib (generic form of Celebrex), the number one pre- scribed osteoarthritis drug. This study was just published in Decem- ber of 2011 in the journal Osteoarthritis and Cartilage. NSAIDs relieve inflammation by inhibiting the activity of an inflammation-causing enzyme called COX-2. That's all well and good, but they also inhibit a companion enzyme called COX-1, which protects the lining of the digestive tract and blood vessels. Therefore, without adequate COX-1 protection, you may have ulcers and leaking of the blood vessels. THE GOLDEN KNIGHT RIDES AGAIN It shouldn't surprise you that curcumin and its formidable anti- inflammatory powers offer an effective and safe alternative to these dangerous NSAIDs. Curcumin inhibits the COX-2 enzyme but does not affect healthy levels of COX-1. Inflammation causes pain, so if you relieve inflammation, you relieve pain. Not only does curcumin relieve inflammation and pain, it can actually help rebuild worn cartilage, restoring joints to their youthful flexibility. Curcumin is also such a potent anti - oxidant that it can actually help repair the oxidative damage caused by inflammation. 18 r CURCUMINTHE 21ST CENTURY CURE Medicine Hunter Chris Kilham, who has conducted medical research in more than 20 countries, is sometimes called "The Indi- ana Jones of Natural Medicine." He says curcumin deserves "superstar status" among healing plants. "Medicines should heal, not hurt. They should promote life, not take it away. In part, due to disappointment with drugs, and in part due to a belief that natural remedies are safer than most pharmaceuticals, many people seek natural remedies to alleviate pain. But where do they look? Enter curcumin, a derivative of turmeric root, that literally can erase pain quickly and powerfully, without negative effects," says Kilham. The research is very impressive: Reduce inflammation: Biological indicators of inflammation were reduced by as much as 99% with curcumin, offering almost complete relief for chronic pain sufferers and providing a powerful promise for prevention and treatment of other diseases caused by inflammation. Cartilage regeneration: Not only does curcumin help reduce the inflammation, it actually helps prevent the breakdown of cartilage (the cushions between joints), preventing arthritis from developing or worsening, as shown by Canadian researchers. At least one study shows that curcumin can help build new cartilage cells, reversing what was once thought to be an incurable degenerative disease. Pain relief: An Italian study showed that people diagnosed with knee osteoarthritis were able to reduce their need for NSAIDs by 63% when they took curcumin. As a welcome side effect in this study, it was discovered that curcumin produced a 16-fold reduction in par- ticipants' blood levels of CRP, the protein that indicates high levels of inflammation, which also predicts a high risk for heart attack. Once again curcumin has proven to be superior to commonly used pharmaceuticals in relieving joint pain and increasing walk- ing time among people with knee osteoarthritis. In a 2011 study published in the journal Osteoarthritis and Cartilage, patients who took a 500 mg blend of BCM-95 Curcumin and BosPure CURCUMIN, CHRONIC PAIN AND ARTHRITIS r 19 boswellia twice daily had significantly better pain relief than those who took 100 mg of celecoxib (generic form of Celebrex) twice a day. The curcumin-boswellia blend equaled celecoxib in improved joint flexibility. However, Celebrex has serious negative side effects, including irregular heartbeat, depression, increased risk of heart attack and stroke, stomach and intestinal bleeding, chest pain, ulcers, severe abdominal pain, jaundice, one-sided weakness and more. I cannot for the life of me understand why anyone would take this drug when natural curcumin and boswellia offer better results and no serious side effects at all. Rheumatoid arthritis: A landmark 2006 study from the University of Arizona takes the idea of inflammation a step further with the finding that curcumin might prevent rheumatoid arthritis, an autoimmune disease. Another study showed that curcumin was at least as effective as one commonly prescribed pain reliever for rheumatoid arthritis. The most recent research published in the journal Phytotherapy Research in March 2012 shows that people with rheumatoid arthri- tis taking 500 mg of BCM-95 Curcumin twice daily had as much pain relief and improved mobility as those who received diclofenac sodium (generic form of the drug Voltaren, a pharmaceutical com- monly prescribed for people with rheumatoid arthritis) with a vast- ly superior safety profile. Side effects associated with Voltaren include ulcers, bleeding in the stomach and gastrointestinal tract, life-threatening blood loss, irregular heartbeat, chest pain, fainting and many others. No side effects were reported in the patients who received BCM-95 Curcumin. CONCLUSION If you suffer from occasional or continuous joint pain, like most of us, you'll discover that curcumin offers short- and long-term relief. You can find the same kind of pain relief as my sister, who has suf- fered from chronic back pain for decades and found relief with her first dose of curcumin. 20 r CURCUMINTHE 21ST CENTURY CURE C H A P T E R 5 Curcumin and Diabetes Type 2 diabetes is the disease of the Western lifestyle. This dis- ease, once known as adult-onset diabetes, was considered the province of the over-50 crowd. You know the ones I mean, the ones with the potbellies, vegging out in front of the TV, munching on Doritos chased with half a gallon of Rocky Road. Now it is the disease of teens raised on Big Macs and gallons of Coke, 20-somethings with high cholesterol, 30-somethings with erectile dysfunction and 40-somethings with coronary bypasses. Type 1 diabetes is usually diagnosed in children and is charac- terized by a malfunctioning pancreas that does not produce suffi- cient quantities of the body's own insulin to properly utilize the natural sugars in food. Type 2 diabetes, on the other hand, is a lifestyle disease. Scien- tifically, it is characterized by the body's inability to respond to the insulin produced by the pancreas. This is called insulin resistance. The American Diabetes Association reports that 25.8 million Americans suffer from the disease, 7 million of them undiagnosed. Another 79 million are considered "prediabetic," meaning they have some blood sugar malfunction. It's important to note that the vast majority of people with type 2 diabetes are obese. Alarmingly, the number of people with dia- betes in the U.S. has increased by 76% in the last 20 years in pace with the increase in obesity. 21 Just having to live with blood glucose testing, dietary restric- tions and diabetes meds with a wide variety of side effects is only the tip of the diabetes iceberg. DEADLY COMPLICATIONS The complications of diabetes are daunting: Heart disease is reported as a cause of death in 68% of people with diabetes aged 65 and over. People with diabetes have a 2 to 4 times greater chance of dying of heart disease or stroke than those without the disease. High blood pressure is reported in 67% of those with diabetes. Diabetes is the leading cause of new cases of blindness in peo- ple aged 29 to 74. Kidney failure attributed to diabetes accounts for 44% of all new cases. In 2008, the latest year for which statistics are available, more than 202,000 people with end-stage kidney disease due to diabetes were living on dialysis or with a kidney transplant. 22 r CURCUMINTHE 21ST CENTURY CURE Nerve damage is experienced by 60 to 70% of people with dia- betes, often causing erectile dysfunction in men. Diabetes causes circulatory problems that led to 65,700 lower limb amputations in diabetics in 2008. Diabetes is listed as a contributing cause of death in more than 231,000 deaths. Science now generally accepts that diabetes is an inflammatory condition, as is obesity. As you might well imagine, this is where curcumin comes into the picture. THE GOLDEN KNIGHT REDUX Remember the role of free radical oxygen molecules as underlying causes of most disease processes from Chapter 1? Curcumin's antioxidant and anti-inflammatory properties are especially applicable to diabetes and its complications. Here's what the studies show curcumin can do: Reduce glucose production in the liver: A Japanese study shows that curcumin has the ability to reduce the liver's natural produc- tion of glucose, which in healthy people is balanced by the pan- creas's production of insulin to keep glucose levels steady. Keep glucose out of red blood cells: Scientists treated red blood cells to mimic diabetes, then exposed them to curcumin for just 24 hours. The results: Curcumin normalized the cells in terms of sugar processing and prevented the formation of the fatty globules that clog arteries. Prevent the development of diabetes: A Columbia University study showed that mice with a predisposition toward diabetes and obe- sity given daily doses of curcumin were less likely to develop impaired blood sugar, insulin resistance and full-blown diabetes than those that did not receive curcumin. CURCUMIN AND DIABETES r 23 Lower blood sugar, increase insulin: Indian researchers found that curcumin contains a particularly powerful antioxidant, tetrahydro - curcumin, which lowers blood sugars, increases insulin in the bloodstream (meaning existing insulin is being properly used) and protects against fatty deposits in the arteries indicative of heart disease that is very common in people with diabetes. Through its anti-inflammatory action, several studies show that curcumin can result in better blood sugar control and, therefore, a small, but significant decrease in body weight and fat, potentially reducing the risk of Type 2 diabetes. Promote wound healing: Curcumin also helps in the process of wound healing, something that is especially important to people with diabetes since their wound-healing capabilities are often impaired, leading to infection and amputations. Curcumin should be used at the time when the skin is beginning to re-form around the wound and new skin is being laid down. Protect kidneys: Curcumin has also been found to protect the kid- neys, which we know are vulnerable in people with diabetes, and to help prevent glaucoma and cataracts, common complications among people with diabetes. Reduce liver inflammation: Animal studies show that BCM-95 Curcumin actually reduced liver inflammation, making the livers of the treated obese animals (cats in this case) behave like the livers of non-obese animals. Yes, these are "only" animal studies, but experts like Dr. Ajay Goel of Baylor think that it is logical that BCM-95 will have similar effects on humans, reducing fatty liver and obesity, among the greatest risks for diabetes. Reverse diabetes: Probably the most exciting study came from Egypt in 2008, when researchers discovered curcumin and a bone marrow transplant reversed diabetes in mice with the disease. Researchers theorized that the anti-inflammatory and antioxidant properties of curcumin enhanced the ability of the bone marrow transplant to regenerate insulin-producing cells. 24 r CURCUMINTHE 21ST CENTURY CURE CONCLUSION The evidence is abundantly clear: Curcumin has profound effects against one of the most deadly diseases of our time. Its pathways of action are widely varied, and it is effective against a number of the complications of diabetes as well. While doctors are not yet ready to tell every person with diabetes to take curcumin, they are probably behind the research curve. If I had diabetes, wild horses couldn't keep me away from my curcumin. I don't have diabetes, but curcumin is still a staple of my supplement regimen. CURCUMIN AND DEPRESSION, DEMENTIA r 25 C H A P T E R 6 Curcumin and Memory: Alzheimer's and Dementia 26 Brain health is at the core of who we are as humans. If you have a healthy brain, you have an inquiring mind, you are engaged in the world around you, and you communicate clear- ly with others and form nurturing relationships. Brain chemistry malfunctions take place when, for unknown reasons, brain cells begin to die, resulting in impaired memory, also known as dementia. It is a disease in itself and is not a normal con- sequence of aging. Alzheimer's disease is probably the best-known form of demen- tia, accounting for 50 to 70% of all cases of dementia, so the terms Alzheimer's and dementia are often used interchangeably. Many people with Alzheimer's show signs of dementia caused by strokes or mini-strokes called transient ischemic accidents (TIAs) as well. Dementia can also be caused by chemical exposures, other neu- rological diseases like Parkinson's and Creutzfeldt-Jakob (mad cow disease), long-term depression, multiple strokes, AIDS, chronic drug use, infections and toxic side effects of medications. It can also be caused by head injuries, as we've learned through recent media coverage of compromised brain function in professional football players and boxers who are exposed to relentless blows to the head. For the most part these, like Alzheimer's, are incurable and irreversible. Conventional medicine has little to offer in terms of treatment. There are also forms of dementia that can be treated and poten- tially reversed, including those caused by a blood clot on the brain, a tumor that can be removed, hypothyroidism, hypoglycemia and vitamin B12 deficiency. It is very difficult to diagnose dementia or to differentiate the specific disease called Alzheimer's, so if you or someone close to you is showing signs of memory loss, it is essential to make a thor- ough investigation to determine if the dementia is caused by one of the factors that can be treated and reversed. THE LONG GOODBYE Over time, Alzheimer's inevitably affects memory, thinking and behavior. People with Alzheimer's frequently experience personality changes, anxiety, anger and may even become combative and violent. Alzheimer's has often been called "The Long Goodbye," because it takes such a terrible physical and emotional toll on its victims and their families, usually for years on end. CURCUMIN AND MEMORY: ALZHEIMER'S AND DEMENTIA r 27 Curcumin stimulates electrical communication between brain cells. The downhill memory slide takes its victims from normal com- petency with occasional memory lapses to the loss of the ability to function in the normal world to inevitable death with no apparent mindfulness. Sadly, conventional medicine offers no really effective treatment. The few pharmaceuticals on the market have minimal effects even in slowing the progression of the disease. The National Institutes of Health estimates that more than 5 million Americans have Alzheimer's. Most of them are over 60, although there is an increasing rate of early onset Alzheimer's that can begin as early as the 30s. The frightening statistic is that if you're lucky to live to the age of 85, you have a 50-50 chance of developing dementia. Alzheimer's is inevitably a fatal disease, but it rarely kills quick- ly. Mercifully, people with dementia often have other diseases that take them away before the terrible onset of late-stage dementia. BIOLOGY OF ALZHEIMER'S Here's a little painless biology that explains how normal brain cells work: I like to think of neurons, dendrites and synapses as an electri- cal system in the brain through which thought processes and con- scious and unconscious biological functions take place. Neurons, the brain cells, grow large finger-like projections called dendrites that function very much like wiring in an electrical system. Each neuron has at least one dendrite in and another out in this electri- cal grid that sends a charge to the next dendrite across a tiny space called a synapse. Scientists once thought that we are born with all of the neurons and dendrites we will ever possess, but they've recently learned that over our lifetimes we can grow new neurons and even expand our network of dendrites exponentially in a process called neurogenesis. Some neurons may have hundreds or even thousands of dendrites. Continuing our analogy of the electrical wiring system, you can see that if one wire becomes damaged, thousands of alternative 28 r CURCUMINTHE 21ST CENTURY CURE "electrical" pathways can allow the system to continue to function without impairment. How do you grow more dendrites and refresh your neuron sup- ply? No one is really sure, but there is evidence that the more you challenge your brain, the more extensive your neuronal network will be. Another process characteristic of Alzheimer's is the formation of beta-amyloid plaques and tangles. The beta-amyloid plaques are made of protein that accumulates around the neurons rather than being eliminated by the body, as they are in a healthy person, thereby damaging the function of the brain. In addition, tangled proteins called tau fibers inside the neuron further impair the mental process. These plaques and tangles and disrupted neuronal function most often occur in the hippocampus, the lower part of the human brain that is responsible for memory. For unknown reasons, Alz - heimer's and other forms of dementia frequently affect the area of the hippocampus that controls short-term memory. That's why Grandma may have no idea what she ate for breakfast, but she can recount in great detail the guest list and menu from a dinner party 30 years ago. Alzheimer's is usually staged in seven levels, the seventh stage being inevitably fatal when the neuronal network has failed to the extent that bodily functions that require little or no thought (like swallowing or coughing) become so impaired that their failure is life threatening. The average life expectancy for someone with Alzheimer's is 8 to 10 years from the onset of symptoms, although it may take several years to obtain a diagnosis. YES, IT CAN BE INHERITEDOR NOT There is a genetic component of Alzheimer's, both with late onset and the increasingly diagnosed early onset. Scientists have identified the genetic component, called APOE that can forecast a person's CURCUMIN AND MEMORY: ALZHEIMER'S AND DEMENTIA r 29 risk for the disease later in life. But the presence of the APOE gene is not at all predictive that the carrier of the gene will develop the disease. In fact, many people who do have the APOE gene never develop Alzheimer's, and conversely, many without the genetic component do develop it. Baby Boomers experiencing the emotionally and financially draining farewell of their grandparents and parents are under- standably concerned about their own futures. Prevention and slowing mental deterioration in the early stages of Alzheimer's is where BCM-95 Curcumin may be the most help- ful, according to pioneering Alzheimer's researcher Ralph Martins, head of Australia's Sir James McCusker Unit for Alzheimer's Dis- ease Research for more than 20 years. For most people, Dr. Martins says, "I think curcumin should play an important role in slowing down the disease or possibly pre- venting it." He adds, "In terms of curcumin's ability to slow down the progression of preclinical Alzheimer's disease, there is now very strong evidence from animal trials that curcumin markedly lowers the level of beta-amyloid in the brain and does it primarily by affecting its aggregation (clumping of the plaque) and facilitating its clearance (elimination from the body). In addition, curcumin is a powerful antioxidant and thus plays a significant role in reducing brain damage caused by oxidative stress." Dr. Martins is currently engaged in human studies using BCM- 95 Curcumin to verify this preliminary work. OTHER MEANS OF PREVENTION Increased physical and mental activities have been shown to keep brain cells active, improve circulation and stave off dementia. Stress management and what the Alzheimer's Research and Prevention Foundation calls "brain aerobics" (challenging your brain to activ- ities outside your normthink Sudoku or writing haiku) are also important elements in preventing dementia. Several studies also show the healthy Omega-3 fats from fish 30 r CURCUMINTHE 21ST CENTURY CURE are key components in brain health and memory preservation as is a healthy diet rich in antioxidants like berries, green leafy vegeta- bles, nuts, seeds and citrus fruits. While there are several anti-dementia pharmaceuticals on the market, they do not reverse dementia and they have limited effec- tiveness in slowing its progress. THE GOLDEN KNIGHT RIDES AGAIN Curcumin's unique ability to cross the blood-brain barrier means that it can affect brain chemistry and the survival mechanisms of brain cells (neurons), producing preventive and healing effects that few other nutrients can offer. Curcumin, and particularly BCM-95 Curcumin, holds great promise for those with dementia and particularly for people with a history of Alzheimer's in their families. There has been extensive research in this area (a search of curcumin+dementia in the Nation- al Institutes of Health database turns up 134 studies). The enthusi- asm for the results is becoming intense. Compared to the Western world, there is a much lower rate of Alzheimer's disease in India, where curcumin is eaten in large quan- tities in the curries that are a staple of the Indian diet. In fact, the rate of Alzheimer's in India among people ages 70 to 79 is about one-quarter of the rate in the U.S. where curcumin is rarely includ- ed in the diet. Even eating a small amount of curcumin seems to have an effect. One study showed better memory among 60- to 93-year- olds who ate curry just once a month than among those who never ate it. Here's a fascinating story about Indian people who tend to eat curry two or three times a day, so their dietary intake of curcumin is exceptionally high: Researchers conducting autopsies on the brains of Indians who died of all causes found that there was an unusual yellowish color in their brain stem (hippocampus) tissue. This color, not seen in CURCUMIN AND MEMORY: ALZHEIMER'S AND DEMENTIA r 31 people of other ethnicities, was taken as proof that curcumin indeed crosses the blood-brain barrier and that large quantities of it are actually absorbed into the brain tissue. Here are a few of the most interesting research results on cur- cumin and the brain: Grow new brain cells: Until recently, scientists believed that it was impossible to grow new brain cells, but they busted that myth with the discovery of neurogenesis, the scientifically validated creation of new brain cells. University of Florida researchers have now con- firmed that curcumin stimulates the birth of new neurons, particu- larly in the hippocampus, the seat of memory in the human brain. Protect brain cells: Authors of a study published in the journal Cur- rent Alzheimer's Research were enthusiastic about antioxidant properties of curcumin to prevent brain cell deterioration and death. Inflammatory cells called cytokines have a role in speeding up Alzheimer's, and the abilities of curcumin to inhibit the COX-2 enzyme can help protect those brain cells. Destroy plaques and tangles: Scientists at UCLA called curcumin "anti-amyloid" for its ability to overcome the beta-amyloid protein that forms the plaques and tangles. They also noted that people with Alzheimer's show signs of inflammation in their brains and credit curcumin's anti-inflammatory properties with an ability to address that problem. Another UCLA animal study showed cur- cumin supplements reduced substances believed to cause plaque by 43 to 45%. Some researchers have suggested curcumin binds directly to plaques and eliminates them. The most exciting new research on curcumin, and particularly the BCM-95 formulation, suggests that curcumin helps dissolve those beta-amyloid plaques that are widely believed in the scientific community to cause the neuronal "short-circuit" that results in mem- ory loss indicative of Alzheimer's disease and other forms of dementia. The 34 participants in this study published in the Journal of Psychopharmacology had all been diagnosed with probable or possible Alzheimer's disease based on criteria set by the National 32 r CURCUMINTHE 21ST CENTURY CURE Institute of Neurological and Communicative Disorders and StrokeAlzheimer Disease and Related Disorders Association. They were given either a placebo or one or four grams of BCM-95 Curcumin. There were few side effects and, interest ingly, the most side effects occurred in the placebo group. Researchers commented on the resulting increased levels of beta-amyloid in the bloodstream as indicative that the beta-amyloid plaque formations in their brains were dissolving and the blood- stream was carrying them away for waste disposal. In addition, BCM-95 has been selected for study in a ground- breaking, exciting, year-long Australian clinical study searching for ways to prevent or delay the expected declines of Alzheimer's dis- ease, being conducted by renowned Australian researcher Ralph Martins, Ph.D., who directed the study on beta-amyloid plaque mentioned previously on page 30. As head of the Sir James McCusker Unit for Alzheimer's Dis- ease Research for over 20 years, Director of the Centre of Excel- lence for Alzheimer's Disease Research and Care, Director and Inaugural Chair for Ageing and Alzheimer's Disease at Edith Cowan University in Perth, Australia, Dr. Martins is working to develop an early diagnostic blood test in order to effectively prevent and/or treat this devastating degenerative brain disease. In addition, Dr. Martins and his team are working to substan- tiate their theory that the presence of curcumin in the retina of the eye, when it is bound to the beta-amyloid plaque, may help doctors diagnose Alzheimer's in its earliest stages and perhaps reverse the disease process with more curcumin. I am very excited about Dr. Martins' work and look forward to results that will change the face of Alzheimer's disease, prevention, diagnosis and treatment in the not-too-distant future. Curcumin studies in animal models of Alzheimer's disease have demonstrated that it can play a significant role in the destruction of beta-amyloid plaque. It is also a powerful antioxidant, with an ORAC value of 1.5 million per 100 grams, as determined by the United States Department of Agriculture (USDA). Other studies CURCUMIN AND MEMORY: ALZHEIMER'S AND DEMENTIA r 33 have shown that curcumin plays a role in neuronal regeneration. All these properties contribute to its potential utility in addressing this brain disease. "I chose BCM-95 Curcumin for my human studies because it has published human bioavailability data," says Dr. Martins. "Therefore, I can use a reasonable amount and expect that the serum levels will achieve a therapeutic range for a significant peri- od of time." Improve memory in people with Alzheimer's: This exciting Indian study explores multiple ways in which curcumin not only prevents Alzheimer's and slows the progression of the disease, but actually improves memory in people already diagnosed with the disease. Chelating heavy metals: The same Indian study says that curcumin helps eliminate heavy metals from brain cells and shields the cells from heavy metal contamination. These heavy metals have long been implicated in Alzheimer's and dementia. CONCLUSION I'm reluctant to use superlatives in a book like this, but I am great- ly excited about the power of curcumin to protect the brain and to prevent, treat and even reverse dementia and Alzheimer's through a broad network of chemical pathways. Although I would caution you that most of these studies are done at the cellular level or on animals, and human studies are just getting underway, there are ample reasons for encouragement. Although doctors are highly unlikely to recommend curcumin for the treatment of these brain-related diseases, if I had a loved one suffering from one of them, I'd be very eager to give highly absorbable BCM-95 Curcumin a try. 34 r CURCUMINTHE 21ST CENTURY CURE C H A P T E R 7 Curcumin, Depression and Other Brain Disorders Curcumin's value in treating dementia and Alzheimer's disease opens the door to its considerable value in treating and pre- venting a variety of other malfunctions of the brain and the neuro- transmitter system. DEPRESSION Over a lifetime, 16.5% of the U.S. adult population (18.8 million people) suffers from a major depressive disorder and 30% of those cases are so severe that they impair the ability to work or even to function in the world in normal terms. We know that women are 70% more likely to develop depres- sion, that Caucasians have a 40% higher risk for depression than African-Americans and that people between the ages of 18 and 29 are at much greater risk of major depressive disorders than people over 60. Depression affects children as well. Government statistics show 4.7% of 13- to 18-year-olds suffer from severe mood disorders and girls are nearly twice as vulnerable as boys. The rate of teen depres- sion is increasing by an alarming 23% per year. We're not talking about the occasional day or even days of feeling blue. We're not talking about the normal ups and downs of life, the loss of a relationship, the loss of a job or even the loss of a loved one. 35 Depressive disorder is a crushing inability to cope with life and the world. Yet only about half of its sufferers get treatment and 80% of the treatment that conventional medicine offers is com- pletely ineffective. Standard medical treatment for depression is usually a series of antidepressant pharmaceuticals with a high risk of serious side effects and little or no effect. Research shows that antidepressants work for only 35 to 45% of the population, and some figures sug- gest the effectiveness rate is as low as 30%. Worse yet, antidepres- sants like Prozac, Paxil and Zoloft have been linked to suicide, violence, psychosis, abnormal bleeding and brain tumors. What causes depression? Certainly short-term depression can be the result of life events. Long-term trauma, such as sexual abuse and a family history of depression can also be factors. Dr. Hyla Cass, a cutting-edge integrative physician with a spe- cialty in psychiatry, believes that the cause of depression is often biochemical, an imbalance in brain chemistry. The answer, says Dr. Cass in her book Natural Highs: Feel Good All the Time, is in "a variety of nutrients that both make up and fuel the brain, nervous system and neurotransmitters. So a low mood may have less to do with past trauma or a faulty belief system than with deficient nutrients." "Mood-lifting serotonin, motivating noradrenaline and sleep- enhancing tryptophan are the neurotransmitters most often defi- cient in people with depression," says Dr. Cass. You guessed it: Here comes the Golden Knight on his charger again, offering solutions to brain imbalances that are at the foun- dation of major depression. Not only does curcumin enhance nora- drenaline and tryptophan levels, but it also increases the production of dopamine, another neurotransmitter that controls emotional response and the ability to experience pleasure and pain. Numerous studies underscore curcumin's ability to improve lev- els of neurotransmitters and thereby improve mood. Many people stumble on curcumin's antidepressant action when they take it for another condition, most typically to address 36 r CURCUMINTHE 21ST CENTURY CURE joint pain. The action is so subtle that some users have written that they didn't realize their depression had disappeared until they stopped taking curcumin and the depression returned. Here are highlights of the research on curcumin and depression: Increases serotonin and dopamine levels: Several studies support curcumin's ability to boost mood by increasing levels of mood- enhancing neurotransmitters. At least one study adds that curcum- in combined with some antidepressant prescription drugs improves their effectiveness. Acts like pharmaceutical drugs without the risks: Exciting new research shows that BCM-95 Curcumin is as effective as the popular antidepressant pharmaceuticals Prozac (fluoxetine) and Tofranil (imipramine), without the side effects associated with the pharmaceutical drugs that include weight gain and loss, increased depression and increased suicidal tendencies. Another interesting finding published in 2011 showed that BCM-95 Curcumin did nothing to increase the effectiveness of the two pharmaceutical antidepressants, but did just as well as each of them on its own. The bottom line: If you suffer from depression, it is worth a try to go with BCM-95 Curcumin, with the permission of your health care professional. Please don't stop taking your antidepressants cold turkey because it can cause some serious side effects like dra- matic moods swings, a worsening of the underlying depression or other condition, extremely vivid dreams, aggression and suicidal tendencies. Generates new brain cells: Curcumin can actually help in the for- mation of new nerve cells, called neurogenesis, helping create a healthy balance of the numerous neurotransmitters needed for a healthy brain, better memory and a positive mood. Antioxidant and anti-inflammatory mood improvement: Indian researchers are clearly enthusiastic about curcumin. Several studies further the body of evidence in favor of curcumin's positive effects on mood. CURCUMIN, DEPRESSION AND OTHER BRAIN DISORDERS r 37 OTHER BRAIN-PROTECTIVE FUNCTIONS OF CURCUMIN Curcumin's ability to relieve depression and dementia are consid- erable, but there's more in the realm of scientific research on cur- cumin's brain-protective effects: Blocks brain tumor formation: Researchers in New York discov- ered that injected curcumin blocks the formation of cancerous brain tumors in mice. Anti-convulsant: An animal study from India found that curcumin supplements stop epileptic seizures. Protects brain cells from stroke damage: Oxygen deprivation is the main cause of post-stroke brain damage and disability. A Universi- ty of Missouri animal study showed that injected curcumin given for two months after a stroke greatly diminished the death of brain cells. Another study showed that after a stroke, curcumin helped prevent damage to the all-important blood-brain barrier, minimiz- ing the risk of infection and other types of brain damage. Counters effects of traumatic brain injury: UCLA animal research - ers found that a diet high in curcumin greatly reduced brain dam- age and cognitive impairment after a traumatic brain injury. Treatment for Parkinson's disease: Parkinson's disease is a degen- erative disease of the central nervous system that includes move- ment-related impairment, including shaking, slowness of movement and rigidity of limbs. In its advanced state, Parkinson's can include dementia and behavioral problems. Modern medicine treats the symptoms of Parkinson's, since there is no known cure. Inflammation is certainly a part of Parkinson's, and we already know that curcumin is a powerful anti-inflammatory and anti - oxidant. In addition, 2012 research from the Northeast Ohio Med- ical University suggests that curcumin has neuroprotective elements as well, particularly in containing the protein accumulations like 38 r CURCUMINTHE 21ST CENTURY CURE the plaques and tangles found in Alzheimer's. Researchers in that study said, "Curcumin possesses therapeutic potential in the ame- lioration of a host of neurodegenerative ailments as evidenced by its antioxidant, anti-inflammatory and anti-protein aggregation effects." Who knows what the future holds, but this research may even- tually show curcumin's value in treating other neurodegenerative diseases like multiple sclerosis and ALS. In another study, Indian researchers concluded that curcumin holds therapeutic potential for people with Parkinson's disease because of its antioxidant properties, especially those that help rebuild glutathione levels in cells, enhancing nutrient metabolism and immune response. CONCLUSION If you or a loved one suffer from depression, or other brain disor- ders mentioned in this chapter, rundon't walkto your nearest health food store and get yourself some BCM-95 Curcumin. You have nothing to risk and everything to gain. Next step: If you are taking prescription antidepressants, sched- ule an appointment with your doctor. Show him or her this book and ask how to wean yourself from the drugs so you can determine if side-effect free curcumin will work better for you. CURCUMIN, DEPRESSION AND OTHER BRAIN DISORDERS r 39 C H A P T E R 8 Curcumin and Digestive Disorders 40 Time after time, curcumin has proven its value in treating a wide variety of digestive disorders, largely because of its anti- inflammatory effects. Digestive disorders range from mild indigestion to life-control- ling irritable bowel syndrome to life-threatening diseases like ulcer- ative colitis and colorectal cancer. Each year, 62 million Americans are diagnosed with some form of digestive disorder. Irritable bowel syndrome, a complex and unpredictable basket of painful problems ranging from diarrhea to constipation and cramping, bloating and pain, goes largely undiagnosed with an esti- mated 75% of sufferers not getting medical treatment at all. Colorectal cancer kills about 150,000 people every year, and ulcerative colitis and Crohn's disease make life a living hell for 140,000 Americans. Liver disease is included in this category because of the liver's key role in the digestive process. HERE COMES THE GOLDEN KNIGHT AGAIN Because inflammation is a major factor in all digestive disorders, curcumin is predictably very effective in helping prevent, treat and heal many digestive problems. Herbalists consider curcumin to be a digestive and a bitter, which means it helps ease digestion and aids liver function. It also stimulates bile production in the liver and gallbladder and improves the ability to digest fats. Here's a listing of various digestive disorders and how curcum- in can help: Ulcerative colitis: A Japanese study, which involved human subjects, a rarity in curcum- in research to this point, sug- gests curcumin supplements are a safe way of preventing recurrences of the disease and reducing the side effects, which include severe bleed- ing, ruptured colon, dehy- dration and liver disease in the small intestine. Crohn's disease: Researchers at the MD Anderson Cancer Center in Houston recom- mend we "get back to our roots" and take advantage of the anti-inflammatory effects of curcumin for many dis- eases, including Crohn's, an inflammatory disease usually affecting the large and small intestines. Crohn's and ulcerative colitis are sometimes called inflammatory bowel disease. Colon cancer: We've already examined curcumin's anticancer prop- erties in Chapter 3, but it's worth mentioning it again here. A land- mark study from the American Health Foundation shows that curcumin interferes with the process by which malignant colon tumors develop, stopping them before they become dangerous. CURCUMIN AND DIGESTIVE DISORDERS r 41 The human liver (top) and digestive system. Irritable bowel syndrome: Irritable bowel syndrome is an unpleas- ant cluster of problems that fluctuate between diarrhea and consti- pation with abdominal cramps, bloating and gas in the mix. A study from the Medical College of Wisconsin helps us understand better the anti-inflammatory capabilities of curcumin, which stop the growth of additional blood vessels to feed the inflamed area in the digestive tract. This process, called angiogenesis, is also part of the process by which cancerous tumors get their blood supply, enabling them to grow. Familial adenomatous polyposis: In a study, published in the Jour- nal of Clinical Gastroenterology and Hepatology, five patients with an inherited form of precancerous polyps in the lower bowel known as familial adenomatous polyposis (FAP) were treated with regular doses of curcumin and quercetin (another powerful anti - oxidant found in onions and garlic) during an average of six months. The average number of polyps dropped 60.4 percent, and the average size dropped by 50.9 percent. Liver damage: An interesting Finnish animal study involved feed- ing rats a diet that simulated high alcohol consumption. Animals given curcumin at the same time had none of the signs of liver dam- age normally associated with alcoholism. Researchers theorize that curcumin blocks a molecule called NFkB, which is responsible for inflammation and tissue death. Another study showed that animals with 70% of their livers removed regenerated new liver tissue in as little as 24 hours with the help of curcumin. CONCLUSION Once again, curcumin proves its considerable value in fighting inflammation with remarkable results in treating, preventing and stopping the progress of a variety of digestive disorders. The results in treating and preventing liver disease, a potentially fatal affliction, are even more remarkable. 42 r CURCUMINTHE 21ST CENTURY CURE C H A P T E R 9 Curcumin and Other Diseases Looking back at the previous chapters, it seems like there is noth- ing that curcumin can't prevent or treat. While that's not exact- ly true, there are several other diseases for which curcumin is highly effective, yet they don't fall neatly into the categories of the other chapters. Nevertheless, they are well worth mentioning. So here's the "grab bag" of other ways curcumin can be enor- mously helpful in protecting: Lungs: Existing drugs have not been shown to be effective in the treatment of lung conditions resulting from occupational and environmental exposures to mineral dusts, airborne pollutants, cigarette smoke, chemotherapy, radiotherapy and other causes of acute and chronic inflammatory lung disease. Several animal stud- ies show that curcumin minimizes lung injury and fibrosis caused by radiation, chemotherapeutic drugs and toxic substances. The researchers also note that studies support the conclusion that curcumin plays a protective role in chronic obstructive pulmonary disease, acute lung injury, acute respiratory distress syndrome and allergic asthma. A recent animal study from the United Arab Emirates confirms the usefulness of curcumin in protecting against the toxic effects of air pollution. Kidneys: When Indian researchers artificially induced kidney dis- ease in animals, they found that curcumin protected them from 43 the toxic buildup that occurs when kidneys can no longer filter the blood. The study also showed that the antioxidants in curcumin protected kidneys against injury. Eyes: Another Indian study showed that the growth of cataracts in animals with diabetes was significantly slowed when the animals were given curcumin supplements. Researchers theorize that this same protection can be extended to human cataracts that occur when the lens of the eye becomes cloudy. It is common in older people. Want more? Here is a handful of other diseases that curcumin may help treat or prevent: Obesity: Obesity is such a huge problem that it probably deserves its own chapter or even its own book. Two-thirds of Americans are overweight, of which one-third are obese. Anything that can help with weight control is welcome. Through its anti-inflammatory 44 r CURCUMINTHE 21ST CENTURY CURE Immune system: white blood cells attack viral invaders. action, several studies show that curcumin can result in better blood sugar control and, therefore, a small but significant decrease in body weight and fat. Perhaps more important, it also increases levels of a protein called adiponectin that are usually low in obese people. By raising adiponectin levels, normal weight can return. Curcumin also helps cut off blood supply to excess fat cells, reduc- ing their size and number. Recent research published in the British Journal of Nutrition in late 2011 showed that BCM-95 Curcumin reduced liver inflam- mation, neutralizing the risk for a fatty liver associated with obesi- ty. So, not only does curcumin help keep weight and blood sugar under control, it can reduce the inflammatory marker for poten- tially fatal liver disease and lessens the risk for a wide variety of dis- eases, including diabetes, heart disease and cancer. Multiple sclerosis: This progressive neurological disease eventually leads to complete disability. Researchers theorize that the same properties in curcumin that protect brain cells may also be helpful in protecting the muscle fibers that are affected by multiple sclero- sis (MS). In a Vanderbilt animal study, animals with an MS-like illness showed no signs of the disease after being treated with cur- cumin while those that did not get curcumin became paralyzed. Immune system: In particular, studies on HIV show that curcumin slows the ability of the virus to duplicate itself and spread, reduc- ing the viral load on people whose immune systems are already severely compromised. This human study reduced the viral load in 57.8% of the participants. In addition, a Kenyan epidemiological study of people of Indian descent (who eat curry) and those of African descent (who don't eat curry) showed that those of African descent were far more likely to contract HIV. CONCLUSION This chapter demonstrates the scope of the potential for curcumin to create profound biological changes and enormous benefits to CURCUMIN AND OTHER DISEASES r 45 human health. As mentioned in earlier chapters, there are few human studies. Most of the studies are lab studies on cells or ani- mals, and it is not certain that they can translate to human bene- fits. Yet the promise is so great that it is well worth adding curcumin, the right kind of curcumin, to your daily supplement regimen. 46 r CURCUMINTHE 21ST CENTURY CURE References Chapter 2 Soni KB, Kuttan R. Effect of oral curcumin administration on serum peroxides and cho- lesterol levels in human volunteers. Indian J Physiol Pharmacol. 1992 Oct;36(4):273275. Ramaswami G, Chair H et al. Curcumin blocks homocysteine-induced endothelial dys- function in porcine coronary arteries. J Vasc Surg. 2004 Dec;40(6): 121622. Shar BH, Nawaz Z. Inhibitory effect of curcumin, a food spice from turmeric, on platelet- activating factor- and arachidonic acid-mediated platelet aggregation through inhibition of thromboxane formation and Ca2+ signaling. Biochem Pharmacol. 1999 Oct 1;58(7):11 6772. Li HL, Liu C et al. Curcumin prevents and reverses murine cardiac hypertrophy. J Clin Invest. 2008 Feb 21. Zhao J, Zhao Y et al. Neuroprotective effect of curcumin on transient focal cerebral ischemia in rats. Brain Res. 2008 Sep 10;1229:22432. Epub 2008 Jul 8. Chapter 3 Aggarwal BB, Kumar A et al. Anticancer potential of curcumin: preclinical and clinical studies. Anticancer Res. 2003 JanFeb;23(1A):363398. Link A, Balaquer F. Cancer chemoprevention by dietary polyphenols: promising role for epigenetics. Biochem Pharmacol. 2010 Dec 15;80(12):177192. Epub 2010 Jun 26. Anand P, Sundaram C. Curcumin and cancer: an "old-age" disease with an "age-old" solution. Cancer Lett. 2008 Aug 18;267(1):133164. Epub 2008 May 6. Ireson CR, Jones DJ et al. Metabolism of the cancer chemopreventive agent curcumin in human and rat intestine. Cancer Epidemiol Biomarkers Prev. 2002; 11(1):105111. Cheng AL, Hsu CH et4 al. Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions. Anticancer Res. 2001;21(4B):28952900. Nanji AA, Jokelainen K et al. Curcumin prevents alcohol-induced liver disease in rats by inhibiting the expression of NF-kappa B-dependent genes. Am J Physiol Gastrointest Liver Physiol. 2003 Feb;284(2):G3217. Epub 2002 Aug 28. Chapter 4 Chandran B, Goel A. A randomized study to assess the efficacy and safety of curcumin in patients with active rheumatoid arthritis. Phytother Res. March 9, 2012 doi: 10.1002/ ptrr.4639. 47 Antony B, Kizhakedath et al. Clinical evaluation of a herbal product (Rhulief) in the management of knee osteoarthritis. Abstract 316. Osteoarthritis Cartilage. 2011; 19(S1): S145-S146 Rao TS, Basu N et al. Anti-inflammatory activity of curcumin analogues. Indian J Med Res. 1982 Apr;75:574578. Funk JL, Ovarzo JN et al. Turmeric extracts containing curcuminoids prevent experi- mental rheumatoid arthritis. J Nat Prod. 2006 Mar;69(3):351355. Aggarwal BB, Sung B. Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets. Trends Pharmacol Sci. 2009; 30:8594. Liacini A, Sylvester J et al. Induction of matrix metalloproteinase-13 gene expression by TNF-alpha is mediated by MAP kinases, AP-1, and NF-kappaB transcription factors in articular chondrocytes. J. Exp Cell Res. 2003 Aug 1;288(1): 208217. Chapter 5 Fujiwara H, Hosokawa M et al. Curcumin inhibits glucose production in isolated mice hepatcytes. Diabetes Res Clin Pract. 2008 May;80(2):18591. Epub 2008 Jan 24. Weisberg SP, Leibel R et al. Dietary Curcumin Significantly Improves Obesity-Associated Inflammation and Diabetes in Mouse Models of Diabesity. Endocrinology. 2008 Jul;149(7):354958. Epub 2008 Apr 10. Kulkarni SK, Chopra K. Curcumin the active principle of turmeric (Curcuma longa), ame- liorates diabetic nephropathy in rats. Clin Exp Pharmacol Physiol. 2006 Oct;33(10): 940945. Chapter 6 Depression Sanmukhani J, Anovadiya A et al. Evaluation of antidepressant like activity of curcumin and its combination with fluoxetine and imipramine: an acute and chronic study. Acta Pol Pharm. 2011 Sep-Oct;68(5):76975. Garcia-Alloza M, Borrelli LA et al. Curcumin labels amyloid pathology in vivo, disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model, J. Neurochem. 102 (2007) 10951104. Baker CB. Quantitative Analysis of Sponsorship Bias in Economic Studies of Antidepres- sants. The British Journal of Psychiatry. 2003, 183: 498506. Kulkarni S, Dhir A et al. Potentials of curcumin as an antidepressant. ScientificWorld- Journal. 2009 Nov 1;9:123341. Kulkarni S, Bhutani MK et al. Antidepressant activity of curcumin: involvement of sero- tonin and dopamine system. Psychopharmacology (Berl). 2008 Dec;201(3): 43542. Epub 2008 Sep 3. Dementia Baum L et al. Six-month randomized placebo-controlled, double-blind, pilot clinical trial of curcumin in patients with Alzheimer's Disease. Journal of Clinical Psychopharmacolo- gy. Vol 28, Number 1, Feb 2008 pg 110114 48 r CURCUMINTHE 21ST CENTURY CURE Xu Y, Ku B et al. Curcumin reverses impaired hippocampal neurogenesis and increases serotonin receptor 1A mRNA and brain-derived neurotrophic factor expression in chron- ically stressed rats. Brain Res. 2007 Aug 8;1162:918. Epub 2007 Jun 21. Lim GP, Chu T et al. The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. J Neurosci. 2001 Nov 1; 21(21):837077. Chapter 7 Bundy R, et al. Turmeric extract may improve irritable bowel syndrome symptomology in otherwise healthy adults: a pilot study. J Altern Complement Med. 2004 Dec;10(6): 101518. Kawamori T, et al. Chemopreventive effect of curcumin, a naturally occurring anti-inflam- matory agent, during the promotion/progression stages of colon cancer. Cancer Res. 1999;59:597601. Chapter 8 Uysal KT, Wiesbrock SM et al. Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function. Nature. 1997, 389:610614. Leray V, Freuchet B et al. Effect of citrus polyphenol and curcumin-supplemented diet on inflammatory state in obese cats. Br J Nutr. 2011 Oct;106 Suppl 1:S198201.] Lago F Dieguez C et al. Adipokines as emerging mediators of immune response and inflammation. Nat Clin Pract Rhematoll. 2007 3:716724. Awasthi S, Srivatava SK, Piper JT, Singhal SS, Chaubey M, Awasthi YC. Curcumin pro- tects against 4-hydroxy-2-trans-nonenal-induced cataract formation in rat lenses. Am J Clin Nutr. 1996 Nov;64(5):761766. Rai D, Yadav D et al. Design and development of curcumin bioconjugates as antiviral agents. Nucleic Acids Symp Ser (Oxf). 2008;(52):599600. Bright JJ. Curcumin and autoimmune disease. Adv Exp Med Biol. 2007; 595: 425451. Chapter 9 Benny M, Antony B. Bioavailability of BioCurcumax (BCM-95). Spice India. Septem- ber, 2006:1115. Merina B, Iyer VS, et al. A pilot cross-over study to evaluate human oral bioavailability of BCM-95CG (Biocurcumax), a novel bioenhanced preparation of curcumin. Ind J Pharm Sci. 2008;70(4):445449. Poster presentation. Oral Bioavailability of BCM-95 Curcumin in Dogs. 2009 ACVIM Forum/Canadian VMA Convention: June 36, 2009; Montral, Qubec, Canada.] Antony B, Merina B et al. A pilot cross-over study to evaluate human oral bioavailabili- ty of BCM-95 CG (Biocurcumax) a novel bioenhanced preparation of curcumin. Ind J Pharm Sci. 2008;70(4):445450. Bhardwaj R, Glaeser H et al. Piperine, a Major Constituent of Black Pepper, Inhibits Human P-glycoprotein and CYP3A4. The Journal of Pharmacology and Experimental Therapeutics. 2002 Aug;302(2):645650. REFERENCES r 49 About the Author 50 Dr. Jan McBarron received her M.D. from Hahnemann University in Philadelphia and was the fourth woman in the country to become board certified in bariatric medicine. She is a member of the American Medical Association and the American Society of Bariatric Physicians. She volunteered with the 1996 Olympics, has been honored by the Girl Scouts as a "Woman of Achievement" and the Natural Products Association awarded her the "Clinician of the Year" for 2010. While practicing bariatric and preventive medicine, Dr. McBar- ron became disenchanted with the mainstream allopathic medical system and its side effects. She subsequently earned a doctorate in naturopathic medicine and is one of the elite few to hold both med- ical and naturopathic degrees. She believes this enables her to see the complete picture and offer the best in complementary medicine. Dr. McBarron taught at Columbus State University, writes for several newspapers and has appeared on numerous radio and television interviews. She is the author of several books including the best-selling Flavor Without Fat, Being a Woman Naturally, Hormonal Harmony and The Peachtree Diet. In addition to her private medical practice, Georgia Bariatrics in Columbus, GA, Dr. McBarron co-hosts the #1 nationally syndi- cated health talk radio show "Duke and The Doctor," with her husband, Duke Liberatore. Talkers Magazine has ranked them in the top 100 most important radio hosts in America. They are broadcast in over 125 markets nationwide. For a list of their radio station affiliates visit www.dukeandthedoctor.com. OPTIMAL BODY DEFENSE David Lyons with Arnold Schwarzenegger Fight Back Against Excess Inflammation </p>