Creatine kinase (CK, also known as creatine phosphokinase or phospho-creatine kinase) is a member of a highly
conserved family of phosphoryl transfer enzymes called phosphagen (guanidino) kinases and is expressed in
various cells and tissue types. In humans, there are three different isoenzymes, BB, MM, and MB. CK-MB (also
known as CK-2) is one of three forms (isoenzymes) of the enzyme creatine kinase (CK) and found primarily in
heart muscle cells. CK-MB is normally undetectable or very low in the blood. CK is released from muscle cells and
is detectable in the blood whenever there is muscle damage and CK-MB will typically only be present in significant
amounts when the heart is damaged.
What is CK-MB test?
A creatine kinase-MB (CK-MB) test is usually used as a follow-up test to an elevated creatine kinase (CK) in order
to determine whether the increase is due to heart damage or skeletal muscle damage. It can also be used to
detect a second or subsequent heart attack or to monitor for additional heart damage. There are two main test
methods to detect CK-MB, Electrophoresis and Immunoassays. CPK-MB test is a sensitive and specific test for
myocardial infarction (MI) which measures CK-MB in the blood.
How is CK-MB used as a cardiac marker?
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