CIPROFLOXACIN PHARMACOKINETICS IN CALVES
Indian Journal of Pharmacology 2003; 35: 227-231
Correspondence: S.K. Garg
DISPOSITION KINETICS OF CIPROFLOXACIN FOLLOWING A SINGLE
INTRAVENOUS DOSE IN CALVES
A. MOHAN, S.K. GARG
Department of Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, U.P. Pandit
Deen Dayal Upadhyaya Veterinary Science University and Cattle Research Institute, Mathura-281 001.
Manuscript Received: 21.6.2002
Objective: To determine the pharmacokinetics and suggest rational dosage regimens of ciprofloxacin
Methods: Ciprofloxacin (5 mg/kg, i.v.) was administered to five calves and the plasma concentrations
of the drug were estimated spectrofluorimetrically. The pharmacokinetic parameters were determined
by the compartmental and model-independent methods. Using the derived pharmacokinetic determinants,
the dosage regimens of ciprofloxacin for calves were computed.
Results: Plasma ciprofloxacin concentrations at various time intervals initially declined rapidly from
5.71+0.63 mg/ml at 0.04 h to 3.06+0.35 mg/ml at 0.75 h and thereafter gradually to 0.35+0.18 mg/ml at 6
h. The pharmacokinetic profile of ciprofloxacin was generated following two-compartment open model.
The values of t1/2a, t 1/2b, Vdarea, AUC and ClB were 0.13+0.02 h, 2.69+0.58 h, 1.71+0.44 L/kg, 11.64+1.55
mg/ml.h and 454.32+59.21 ml/kg/h, respectively. The distribution and elimination characteristics of
ciprofloxacin based on non-compartmental model were not significantly different from those reported
for compartment model.
Conclusion: Based on the pharmacokinetic data in calves and pharmacodynamic properties and
post-antibiotic effect of ciprofloxacin, it is recommended that ciprofloxacin may be administered to
calves at the dose of 5.0 mg/kg body weight at 24 h interval by intravenous route. However, for more
severe infections, to maintain plasma concentrations >1.0 mg/ml, ciproflo