OBJECTIVE: The objectives of our study were to collect the local data and to determine
the serum lipid profile in-patients of primary hypothyroidism, in relation to different TSH
DESIGN: It was cross sectional analytic type.
PLACE AND DURATION OF STUDY: Study conducted in the Department of Medicine,
Pathology and Biochemistry, Chandka Medical College and Hospital Larkana. The
period of study was two year from 1st January 2007 to 31st December 2008.
SUBJECT AND METHODS: Two hundred and forty consecutive cases of primary
hypothyroidism were included. A detailed history and physical examination with special
emphasis on fasting lipid profile and other relative investigations made and all the
findings observed were noted in previously made Performa. The data was stratified in
four (4) groups on the basis of serum TSH levels. Group I with levels of 6-20 ìIU/ml,
Group II with levels of 21-40 ìIU/ml, Group III with levels of 40-60 ìIU/ml. Group IV
with levels above 60 ìIU/ml.
RESULTS: Primary hypothyroidism was found to be 4 times more common in female
patients, with male to female ratio of 1:4, the age of patients was ranged between 11 to
76 years. In group-I subject the mean levels of T-Chol, LDL-C, HDL-C and triglycerides
were found to be 194 ± 9.5, 137.6 ± 32.1, 44.6 ± 0.8 and 139 ± 8.7 mg/dl, respectively.
In group-II subjects the mean value of total cholesterol, LDL-C, HDL-C and triglycerides
were found to be 213±10, 189±23.9, 42.2±2.2 mg/dl and 198.3±8.6 respectively. In group
III the mean levels of total serum cholesterol, LDL-C, HDL-C and Triglycerides were
found to be 247.7±39, 201±6.6, 38.7±2.9 and 217±13.3 mg/dl, respectively. In group-
IV patients the mean value of total cholesterol, LDL-C, HDL-C and triglycerides were
found to be 282.4±38.5, 214±11.4, 35.1±1.6 mg/dl and 230.7±17.9, respectively.
CONCLUSION: Our data statistically suggest that the effect of hypothyroidism on the
serum concentration of lipids is more marked in patients with higher serum TSH levels.
Therefore the clinic