Phyllantus amanes (PA) is a perennial herb common in hot central and
southern areas of the Indian Subcontinent.
The extract of the leaves contains various alkaloids, lignans, flavonoids and triterpenes,
including phyllanthin and hypophyilanthis as well as ellagic acid. Traditionally, the plant
has been used as a stomachic, diuretic, ferbifuge, antiseptic, and as a remedy for
diarrhea. In addition, PA has been used to provide support for urogenital conditions.
PA has been reported to exhibit marked antihepatitis B virus surface antigen activity in in-
vivo (Thyagarajan etal (1998), 1490 a, b; Shead, et-al, 1992) and in-vitro studies
(Blumburg, 1991). Infectitious hepatitis is due to the inability of the bodies immune
system to eliminate the virus from the liver cells: hence the “carrier state”. An infection
with the virus is documented by detectable levels of various viral antigens in the blood,
including HBaAg (the surface antigen of the virus) as well as antibodies to the core of
virus (HBc antibodies). In one study, 37 patients with chronic viral hepatitis B were treated
with a daily dose of 600mg of PA for 30 days. 59% of the patients
lost the HBsAg two weeks after the end of the treatment.
Furthermore, none of the cases followed for up to 9 months had
any symptoms of HBsAg. The authors postulated that PA may
inhibit proliferation of the virus by inhibiting replication of the
genetic material of the virus.
In another clinical trial involving 160 children (age 1-12 years) with infective hepatitis, the authors reported
“cures” in 101 children with 59 dropouts. Normal appetite was seen in 7 days, while jaundice, hepatic tenderness,
and other clinical features all disappeared completely within 5 weeks.
Gallstones / Kidney stones
It is reported that over 600, 000 patients are treated for gallstones in the U.S. alone for each year. In South
America, PA is commonly known as “Chanca Piedre” which in the local dialect of Spanish means, “to break
stone”. PA has been used to eliminat