The use of the nasal route for the delivery of challenging drugs such as small polar molecules, vaccines, hormones, peptides and proteins has created much interest in nowadays. Due to the high permeability, high vasculature, low enzymatic environment of nasal cavity and avoidance of hepatic first pass metabolism are well suitable for Systemic delivery of drug molecule via nose Many drug delivery devices for nasal application of liquid, semisolid and solid formulation are investigated to deliver the drugs to the treat most crisis CNS diseases i.e., Parkinson’s dis ease, Alzheimer’s disease because it requires rapid and or specific targeting of drugs to the brain. It is well suitable for the delivery of biotechnological products like proteins, peptides, hormones, DNA plasmids for DNA vaccines to give enhanced bioavailability. This review sets out to discuss some factors affecting nasal absorption, bioavailability barriers, strategies to improve nasal absorption, new developments in nasal dosage form design and applications of nasal drug delivery system. Aarti C. Nangare | Sujit Kakade | Ashok Bhosale "Nasal Drug Delivery System: A Review" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5 , August 2021, URL: https://www.ijtsrd.com/papers/ijtsrd43868.pdf Paper URL: https://www.ijtsrd.com/pharmacy/pharmacy-practice/43868/nasal-drug-delivery-system-a-review/aarti-c-nangare
International Journal of Trend in Scientific Research and Development (IJTSRD)
Volume 5 Issue 5, July-August 2021 Available Online: www.ijtsrd.com e-ISSN: 2456 – 6470
@ IJTSRD | Unique Paper ID – IJTSRD43868 | Volume – 5 | Issue – 5 | Jul-Aug 2021
Page 572
Nasal Drug Delivery System: A Review
Aarti C. Nangare, Sujit Kakade, Ashok Bhosale
Shankarrao Ursal College of Pharmaceutical Sciences and Research Centre, Pune, Maharashtra, India
ABSTRACT
The use of the nasal route for the delivery of challenging drugs such
as small polar molecules, vaccines, hormones, peptides and proteins
has created much interest in nowadays. Due to the high permeability,
high vasculature, low enzymatic environment of nasal cavity and
avoidance of hepatic first pass metabolism are well suitable for
Systemic delivery of drug molecule via nose Many drug delivery
devices for nasal application of liquid, semisolid and solid
formulation are investigated to deliver the drugs to the treat most
crisis CNS diseases (i.e., Parkinson’s dis-ease, Alzheimer’s disease)
because it requires rapid and/or specific targeting of drugs to the
brain. It is well suitable for the delivery of biotechnological products
like proteins, peptides, hormones, DNA plasmids for DNA vaccines
to give enhanced bioavailability. This review sets out to discuss some
factors affecting nasal absorption, bioavailability barriers, strategies
to improve nasal absorption, new developments in nasal dosage form
design and applications of nasal drug delivery system.
KEYWORDS: Bioavailability, Patient Compliance, First pass effect,
absorption Enhancers
How to cite this paper: Aarti C. Nangare
| Sujit Kakade | Ashok Bhosale "Nasal
Drug
Delivery
System: A Review"
Published
in
International Journal
of
Trend
in
Scientific Research
and Development
(ijtsrd), ISSN: 2456-
6470, Volume-5 | Issue-5, August 2021,
pp.572-579,
URL:
www.ijtsrd.com/papers/ijtsrd43868.pdf
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