n/f = not found
Material Safety Data Sheet
Date Prepared: 10/10/03
Prepared By: RC Park
PO Box 445
Technical Assistance: 607-562-2700
Big Flats, NY 14814
Common Name: Amphotericin B
Chemical Name: Amphotericin B
CAS Number: 1397-89-3
RTECS Number: BU2625000
Chemical Family: A Macrolide antibiotic
Therapeutic Category: Antifungal
HEALTH HAZARD INFORMATION
Usual Adult Dose: Amphotericin B is usually administered as 1 mg (base) initially, gradually
increased to a maximum of 50 mg per day by intravenous infusion. The oral adult dose of
Amphotericin B is 10 to 200 mg given four times a day as a lozenge or in tablet form.
Amphotericin B is also applied topically to the skin, as a 3% cream, two to four times a day.
Adverse Effects: Adverse effects following ingestion may include nausea, vomiting, and
diarrhea; adverse effects following topical application may include burning, itching, redness or
other signs of irritation. Systemic effects following injection include unusual tiredness; irregular
heartbeat; muscle cramps or pain; change in urination; blurred or double vision; itching; trouble
breathing; wheezing; tightness in chest; sore throat; fever; shaking chills; numbness, tingling,
pain, or weakness in hands or feet; seizures; unusual bleeding or bruising; indigestion; loss of
appetite; stomach pain; leg, back, or neck pain; headache; and dizziness. Possible allergic reaction
to material if inhaled, ingested or in contact with skin.
Overdose Effects: n/f
Acute: Possible eye, skin, gastrointestinal and/or respiratory tract irritation.
Chronic: Possible hypersensitization and kidney failure. Prolonged contact with skin may cause
contact dermatitis and defatting.
Inhalation: May cause irritation. Remove to fre