Introduction of ZIKV
Zika virus (ZIKV) belongs to the larger group of arboviruses (arthropod borne viruses). The Aedes genus of mosquitoes is the primary route
by which ZIKV is transmitted. Of all the known cases of ZIKV infections, 80% are asymptomatic. The symptoms and signs of patients
affected by ZIKV are similar to Dengue virus (DENV) and other viral diseases. The patient may present with fever, body aches, joint pains,
fatigue, malaise, and conjunctivitis. Two main lineages have been identified so far from entire genome sequencing namely, the African and
Home Products Virus Type Zika Virus
Zika Virus Antibody Products by Targets
E (Envelope Protein)
NS1(Non-structural Protein 1)
Fig.1 A schematic diagram of the ZIKV polyprotein
(top panel) and topological arrangement of individual
viral proteins (bottom panel).
Fig.2 Life cycle of the Flaviviridae.
the Asian lineages. Further divided into two groups, the African lineage is composed of clusters Uganda and Nigeria. Study demonstrated
that single serine to asparagine substitution (S139N) in the viral polyprotein can lead to enhanced infectivity of human and mouse neural
progenitor cells (NPCs) by ZIKV. It was also suggested that this functional adaptation can lead to microcephaly in the mouse fetus, and
higher mortality in neonatal mice.
ZIKV is a positive-sense RNA that is single-stranded. Only a single polyprotein is encoded by its 10.7 kb genome. It is further cleaved into 10
proteins, three of which are structural and seven of which are non-structural (NS1, NS2A, NS2B, NS3, NS4A, NS4B, and NS5).
1. The capsid (C) protein is a multifunctional protein. It binds to viral RNA in the process of nucleocapsid assembly and plays important roles
in virus infection processes by interacting with cellular proteins, modulating cellular metabolism, apoptosis and immune response.
2. Pre-membrane (prM) protein is a 168-residue long structural protein that shares 42% homology between