LOAN AND SECURITY AGREEMENT
T HIS L OAN AND S ECURITY A GREEMENT (as amended, restated, or otherwise modified from time to time, this “ Agreement
” ) dated the Effective Date, between S ILICON V ALLEY B ANK ( “Bank” ) and N UVELO , I NC . , a Delaware corporation,
whose address is 675 Almanor Avenue, Sunnyvale, California 94085 ( “Borrower” ), provides the terms on which Bank will
lend to Borrower, and Borrower will repay Bank.
1. ACCOUNTING AND OTHER TERMS
Accounting terms not defined in this Agreement shall be construed following GAAP. Calculations and determinations
must be made following GAAP. The term “financial statements” includes the notes and schedules. The terms “including” and
“includes” always mean “including (or includes) without limitation,” in this or any Loan Document. Capitalized terms in this
Agreement shall have the meanings as set forth in Section 13. All other terms contained in this Agreement, unless otherwise
indicated, shall have the meanings provided by the Code, to the extent such terms are defined therein.
2. LOAN AND TERMS OF PAYMENT
2.1 Promise to Pay.
Borrower hereby unconditionally promises to pay Bank the unpaid principal amount of all Credit Extensions hereunder
with all interest, fees and finance charges due thereon as and when due in accordance with this Agreement.
2.1.1 Revolving Advances.
(a) Subject to the terms and conditions hereof, Bank shall make Advances to Borrower from time to time until
the Revolving Maturity Date not exceeding the Committed Revolving Line minus the Sublimit Utilization Amount. Until the
Revolving Maturity Date and subject to the terms hereof and the applicable terms and conditions precedent in Sections 3.1 and
3.2 , Borrower may borrow, repay, and reborrow under this Section 2.1.1. The proceeds of the Advances shall be used solely
for working capital and other general business requirements of Borrower.
(b) Pursuant to the terms of Section 2.5(a) , interest on