CMF PO Chemotherapy
Information presented here are events likely to take place, but some rare events may have been excluded.
For more information on this regimen, please call your oncologist, pharmacist or nurse,
or call the Cancer Information Service at 1-888-939-3333.
CHEMOTHERAPY REGIMEN INFO SHEET
(Cyclophosphamide, Methotrexate, and Fluorouracil)
What is CMF?
CMF is a drug combination given for the treatment of breast cancer.
How is it given?
Your treatment plan consists of 6 chemotherapy cycles, each lasting 4 weeks (28 days).
For each cycle, you will receive two drugs (Methotrexate and Fluorouracil) through a vein in
your arm (IV) on first day (Day 1) and eighth day (Day 8) of each cycle. Cyclophosphamide
tablets are to be taken daily from Days 1 to 14 of each treatment cycle. You will have a
blood test before each treatment to check if your blood counts are high enough for you to
If you miss a dose of Cyclophosphamide pills, and you remember within 12 hours of your
usual dose, take the dose then; otherwise skip that day’s dose and take the missed dose on
• Cyclophosphamide can irritate your bladder. Take the cyclophosphamide pills in the
morning. Drink plenty of fluids (at least 8 glasses per day) during the day and empty
your bladder (pass urine) frequently. Tell your oncologist or nurse if you experience pain
on urination, see blood in your urine, or need to urinate small amounts frequently.
• Fluorouracil will make your skin more sensitive to sunlight. Limit the amount of sunlight
to which you are exposed. Apply sunscreen with UVA and UVB protection and an SPF
of at least 30. Use a lip balm with sunscreen for your lips. Wear long sleeved shirts, long
pants and hats.
• Medications in this regimen may make your periods heavier or lighter. Your periods may
even stop completely. This may be permanent. You may develop symptoms of
menopause such as hot flashes, vag