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BOC Sciences provides comprehensive and professional chiral resolution services and synthesis services of chiral
resolution agents. The chiral resolution reagents we synthesized have stable properties, high optical purity, easy
reaction, and high recovery rate.
Chiral resolution, as an important tool in the production of optically active drugs, is a process for the separation of
racemic compounds into their enantiomers in the aspect of stereochemistry. Particularly when the methods of
stereospecific synthesis designed for one of the enantiomers, at present, lead generally to enhanced
enantioselectivity, it is not only the development of analytical methods for the chiral separation to control optical
purity of a large number of pharmaceuticals/therapeutics, administered today, but also the development of
methods for quantitative large-scale separation from their racemic or enantiomeric mixtures. These are the
requirements and challenges of chemists, and chiral resolution opens wider perspectives for such developments.
Figure 1. Methods to obtain enantiomerically pure compounds by means of chiral resolution
Below is a list of our chiral resolution method (include but not limited to the following):
Chiral resolution by crystallization
The separation of racemates into pure enantiomers through crystallization is an important industrial process.
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The crystallization method has the advantages of simple operation, high product purity, and easy realization
of industrial production. Preferential crystallization (seed method) is to add a single enantiomer seed to the
supersaturated solution of t