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BOC Sciences has developed various kinds of anionic liposomes for drug or gene delivery research. All liposomes are prepared under sterile conditions.
Compared with cationic liposomes, anionic liposomes have many characteristics. Anionic liposomes show greater stability in solution. Compared with
neutrally charged liposomes, anionic liposomes have a lower degree of aggregation. Compared with cations, the endocytosis of anionic liposomes is
enhanced. In addition, two FDA-approved drugs that use a negatively charged non-liposomal delivery method include-Restasis (Allergan, used to treat
chronic dry eye) and Durezol (Alcon, used to treat eye inflammation). These drugs facilitate the utilization of negatively charged liposome carriers to
enhance drug delivery.
Anionic Liposomes We Provided:
Due to the "stereostabilization" effect, PEGylated lipids can contribute longer circulation time to liposomes. With a surface hydrophilic protective layer
from the PEG chain, PEGylated liposomes exhibit higher stability, can be released continuously, to prolong blood circulation time, and reduced the
uptake of the mononuclear phagocyte system.
In addition, cholesterol acts as the skeleton of animal cell membranes, which can reduce fluidity, stabilize the bilayer, and control the drug
permeability of the liposome bilayer. Studies have shown that positively charged and negatively charged PEGylated liposome formulations with
modified cholesterol derivatives may be potential drug carriers to improve therapeutic efficacy.
Phosphatidylserine (PS) and phosphatidylglycerol (PG) are two well-known anionic molecules that form liposomes with negative zeta potential. The
zeta potential of liposomes depends on the mole percentage of negatively charged lipids in the liposome preparation.