FIRST AMENDMENT TO LEASE
THIS FIRST AMENDMENT TO LEASE (this “ First Amendment ”) is made as of June 1, 2010 (“
Effective Date ”), by and between ARE- 901/951 GATEWAY BOULEVARD, LLC , a Delaware limited
liability company (“ Landlord ”), and THERAVANCE, INC. , a Delaware corporation (“ Tenant ”).
A. Landlord and Tenant are now parties to that certain Lease Agreement dated January 1, 2001
(the “ Lease ”). Pursuant to the Lease, Tenant leases certain premises consisting of approximately 110,428
rentable square feet (“ Premises ”) in a building located at 901 Gateway Boulevard, South San Francisco,
California. The Premises are more particularly described in the Lease. Capitalized terms used herein without
definition shall have the meanings defined for such terms in the Lease.
B. Landlord and Tenant desire, subject to the terms and conditions set forth below, to amend the
Lease to, among other things, (i) extend the Term of the Lease, and (ii) provide Tenant with an additional tenant
NOW, THEREFORE, in consideration of the foregoing Recitals, which are incorporated herein by this
reference, the mutual promises and conditions contained herein, and for other good and valuable consideration,
the receipt and sufficiency of which are hereby acknowledged, Landlord and Tenant hereby agree as follows:
1. Term . The “ Expiration Date ” of the Term of the Lease is hereby extended from March 31, 2012,
until May 31, 2020. From and after the Effective Date, references in the Lease to “Term” shall mean the
one hundred twenty (120) months commencing on June 1, 2010 and expiring on May 31, 2020.
2. Monthly Base Rent . Notwithstanding anything to the contrary contained in the Lease, commencing
on the Effective Date of this First Amendment, Monthly Base Rent shall be payable pursuant to the