School of Biomedical Engineering, Science & Health Systems
V 1.0 SD 
BIOSENSORS FOR ANTHRAX DETECTION
Faculty/Contact: Kambiz Pourrezaei, Ph.D., Drexel University
With the emergence of biological agents as weapons, transit systems in the U.S. are highly vulnerable targets.
FTA has a strategic goal to enhance security readiness at the Nations transit authorities. This includes a
requirement to develop response options, training programs, and technology enhancements to mitigate and
respond to biological weapons in the transit environment.
Piezoelectric Bulk-Acoustic Biosensor (PBB)
Piezoelectric Cantilever Biosensor (PCB)
The proposed Anthrax Detection System (ADS) involves modification of the existing piezoelectric biological sensors
that will permit the detection of pathogenic organisms. The biosensor package will incorporate an air-sampling device,
biosensing unit and wireless transmission capability. ADS uses antibodies against anthrax as the biological sensing
element and transducers made of piezoelectric materials as the electronic transduction element.
Complementary Biosensor Platforms: Miniaturized, Self Contained, Low
Sensitive, and Reliable.
Specific Aim: To modify two piezo electric biosensor platforms developed in
our laboratories to detect anthrax.
Long Term Goal: Integration of two complimentary anthrax biosensors with air-
sampler, microfluidic, electronic, RF and data display: Anthrax Detection
In the proposed biosensor arrangements, the biological element converts
biochemical changes caused by anthrax initiated immune reaction into the
corresponding acoustic signals. These physical (e.g,. mass) changes are then
transduced by the piezoelectric element into an output electrical signal indicating
the presence of anthrax. An air-sampler will deliver preprocessed ambient air
into the biosensor chamber at specified time intervals. The output electri