LOAN AND SECURITY AGREEMENT
THIS LOAN AND SECURITY AGREEMENT is made and dated as of May 4, 2010 and is entered into
by and between ALEXZA PHARMACEUTICALS, INC., a Delaware corporation (“Parent”), SYMPHONY
ALLEGRO, INC., a Delaware corporation (“Allegro”), and each of Parent’s other subsidiaries joined hereto
(“Joined Subsidiaries”, together with Parent and Allegro hereinafter collectively referred to as the “Borrower”),
and HERCULES TECHNOLOGY GROWTH CAPITAL, INC., a Maryland corporation (“Lender”).
A. Borrower has requested Lender to make available to Borrower a loan in an aggregate principal amount of
Fifteen Million ($15,000,000) (the “Term Loan”);
B. Lender is willing to make the Term Loan on the terms and conditions set forth in this Agreement.
NOW, THEREFORE, Borrower and Lender agree as follows:
SECTION 1. DEFINITIONS AND RULES OF CONSTRUCTION
1.1 Unless otherwise defined herein, the following capitalized terms shall have the following meanings:
“Account Control Agreement(s)” means any agreement entered into by and among the Lender, Borrower
and a third party Bank or other institution (including a Securities Intermediary) in which Borrower maintains a
Deposit Account or an account holding Investment Property and which is intended to perfect Lender’s security
interest in the subject account or accounts.
“ACH Authorization” means the ACH Debit Authorization Agreement in substantially the form of Exhibit I.
“Addicere Proposed Transaction” means the formation of a Subsidiary of Borrower (the “Addicere
Entity”) for the purpose of receiving an exclusive license to Borrower’s Staccato © technology for purposes of
developing nicotine abatement pharmaceuticals.
“Administrative Borrower” has the meaning given to it in Section 11.19.
“Advance” means the Term Loan Advance.
“Advance Date” means the funding date of the Advance.
“Advance Request” means a