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SANTA CRUZ BIOTECHNOLOGY, INC.
The Power to Question
C/EBP δ (M-17): sc-636
Santa Cruz Biotechnology, Inc.
1.800.457.3801 831.457.3800 fax 831.457.3801 Europe
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The transcription factor C/EBP α (CCAAT-enhancer binding protein) is a heat-
stable, sequence-specific DNA-binding protein first purified from rat liver
nuclei that binds avidly to several different cis-regulatory DNA sequences
commonly associated with viral and cellular genes transcribed by RNA poly-
merase II. C/EBP α regulates gene expression in a variety of tissues including
liver, adipose, lung and intestine. C/EBP α uses a bipartite structural motif
to bind DNA. Two protein chains dimerize through a set of amphipathic α
helices termed the leucine zipper. Highly basic polypeptide regions emerge
from the zipper to form a linked set of DNA contact surfaces. C/EBP α
appears to function exclusively in terminally differentiated, growth-arrested
cells. Additional family members include C/EBP ε, C/EBP β, C/EBP δ and
C/EBP γ, all of which exhibit similar DNA-binding specificities and affinities
to C/EBP α. Furthermore, C/EBP β and C/EBP δ readily form heterodimers
both with each other as well as with C/EBP α.
1. Johnson, P.F., et al. 1987. Identification of a rat liver nuclear protein that
binds to the enhancer core element of three animal viruses. Genes and
Dev. 1: 133-146.
2. Landschulz, W.H., et al. 1988. Isolation of a recombinant copy of the gene
encoding C/EBP. Genes and Dev. 2: 786-800.
3. Birkenmeier, E.H., et al. 1989. Tissue-specific expression, developmental
regulation, and genetic mapping of the gene encoding CCAAT/enhancer