Significance of Garlic and Its Constituents in Cancer
and Cardiovascular Disease
Antiglycation Properties of Aged Garlic Extract: Possible Role
in Prevention of Diabetic Complications1,2
Muhammed Saeed Ahmad and Nessar Ahmed3
School of Biology, Chemistry and Health Science, Manchester Metropolitan University,
Manchester M1 5GD, UK
ABSTRACT Diabetes mellitus is a common endocrine disorder characterized by hyperglycemia and long-term com-
plications affecting the eyes, nerves, blood vessels, skin, and kidneys. Increased glycation of proteins and accumula-
tion of advanced glycation endproducts (AGEPs) have been implicated in the pathogenesis of diabetic complications.
Glycation and AGEP formation are also accompanied by formation of free radicals via autoxidation of glucose and
glycated proteins. Compounds with combined antiglycation and antioxidant properties may offer therapeutic potential.
Recent studies suggest that aged garlic extract (AGE) inhibits formation of AGEPs in vitro and formation of glycation-
derived free radicals. S-Allylcysteine, a key component of aged garlic, is a potent antioxidant and can inhibit AGEP
formation. Aged garlic extract and S-allylcysteine deserve more attention and should be investigated to see whether
they can reduce AGEPs in vivo. J. Nutr. 136: 796S–799S, 2006.
KEY WORDS: aged garlic extract diabetes mellitus hyperglycemia S-allylcysteine glycation
Diabetes mellitus is an endocrine disorder characterized by
chronic hyperglycemia, which results from an absolute or
relative deficiency of or resistance to insulin. Diabetes affects
1–2% of the population, and there are around 100 million
diabetic patients worldwide. This figure is expected to double
over the next 10–15 y. Individuals affected by diabetes are
prone to long-term complications such as retinopathy, cataract,
neuropathy, atherosclerosis, nephropathy, embryopathy, and
delayed healing of wounds (1).
Hyperglycemia has a key role in the pathogenesis of
diabetic complications. This has been demonstrated by the