J Neuropsychiatry Clin Neurosci 16:1, Winter 2004
Secretion and Reduces
Insomnia and Anxiety:
A Preliminary Report
D. Warren Spence, M.A.
Leonid Kayumov, Ph.D., DABSM
Adam Chen, Ph.D.
Alan Lowe, M.D.
Umesh Jain, M.D.
Martin A. Katzman, M.D.
Jianhua Shen, M.D.
Boris Perelman, Ph.D.
Colin M. Shapiro, MBBCh, Ph.D., FRCP(C)
Received April 16, 2002; revised September 13, 2002; accepted October
1, 2002. From the Centre for Addiction and Mental Health, Toronto,
Ontario; Sleep Research Laboratory, University Health Network, To-
ronto, Ontario; The Michener Institute for Applied Health Sciences,
Toronto, Ontario; St. Michael’s Hospital, Toronto, Ontario; Dept. of
Psychiatry, University of Toronto, Toronto, Ontario; Toronto Western
Research Institute, Toronto, Ontario. Address correspondence to Dr.
Kayumov, Sleep Research Laboratory, University Health Network,
ECW 3D-035, 399 Bathurst St. Toronto, Ontario M5T-2S8, lkayumov@
Copyright 2004 American Psychiatric Publishing, Inc.
The response to acupuncture of 18 anxious adult
subjects who complained of insomnia was assessed
in an open prepost clinical trial study. Five weeks
of acupuncture treatment was associated with a
significant (p 0.002) nocturnal increase in en-
dogenous melatonin secretion (as measured in
urine) and significant improvements in polysom-
nographic measures of sleep onset latency (p
0.003), arousal index (p 0.001), total sleep
time (p 0.001), and sleep efficiency (p
0.002). Significant reductions in state (p
0.049) and trait (p 0.004) anxiety scores were
also found. These objective findings are consistent
with clinical reports of acupuncture’s relaxant
effects. Acupuncture treatment may be of value
for some categories of anxious patients with in-
(The Journal of Neuropsychiatry and Clinical
Neurosciences 2004; 16:19–28)
The incidence of insomnia is estimated to be 35% to
40% of the adult population. It currently affects
more than 60 million Americans, and this figur