ENVIRONMENTAL ISSUES
AND CANCER
CHAPTER 8
Committee Members
Katherine Squibb, PhD (Chairperson) - School of Medicine, University of Maryland
Shannon Brown, PhD - Johns Hopkins Bloomberg School of Public Health
Tom Burke, PhD, MPH - Johns Hopkins Bloomberg School of Public Health
Katherine Farrell, MD, MPH - Anne Arundel County Department of Health
Phil Heard, MD, MPH - Maryland Department of the Environment
Kathy Helzlsouer, MD, MHS - Johns Hopkins Bloomberg School of Public Health
Carlessia Hussein, RN, Dr. PH - Maryland Department of Health & Mental Hygiene
William B. Icenhower, MD, MPH - St. Mary’s County Department of Health
Christopher A. Loffredo, PhD - Georgetown University School of Medicine, University of Maryland School of Medicine
Diane L. Matuszak, MD, MPH - Maryland Department of Health & Mental Hygiene
Stacey Neloms, MPH - Maryland Department of Health & Mental Hygiene
Jonathan Samet, MD, MS - Johns Hopkins Bloomberg School of Public Health
Andrew Sawyers, PhD - Maryland Department of the Environment
Kathy Wall - American Cancer Society
David M. Wolfe - Maryland Department of Health & Mental Hygiene
Guest Speakers
William Grabau - Maryland Occupational Safety and Health
Walter Cooney, George Harman, Greg McKibbin, Jay Prager, Nancy Reilman, and Ron Turner - Maryland Department
of the Environment
Peer Reviewer
Melissa McDiarmid - School of Medicine, University of Maryland
Chapter Writers
Katherine Squibb, PhD - University of Maryland, School of Medicine
Phil Heard, MD, MPH - Maryland Department of the Environment
Christopher Loffredo, PhD - Georgetown University
Katherine Farrell, MD, MPH - Anne Arundel County Department of Health
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CHAPTER 8 :: ENVIRONMENTAL IS SUES AND CANCER
The prevailing model of carcinogen-
esis holds that cancer cells arise
from the accumulation of many
small alterations in the DNA of
normal cells. These alterations, or
mutations, can be inherited or
newly created. When certain alter-
ations are combined, a cell and its
progeny can begin to grow in an
abnormal, uncontro