Association Between Leukoaraiosis
and Saccadic Oscillation
Chun-Ching Wu, MD; Yi-Ho Young, MD
Objective: To use an audiovestibular test battery to
evaluate patients with leukoaraiosis in order to investi-
gate the relationship between vertigo and dizziness and
Design: Retrospective study.
Setting: Tertiary university hospital.
Patients: A total of 18 elderly patients with vertigo
and dizziness and with leukoaraiosis confirmed by
magnetic resonance imaging (hereafter, leukoaraiosis
group), and another 18 age- and sex-matched patients
with vertigo and dizziness but without leukoaraiosis
(hereafter, nonleukoaraiosis group) were enrolled in
Main Outcome Measures: Each patient underwent
a battery of audiovestibular tests, including audiometry
and electronystagmography (ENG).
Results: In the leukoaraiosis group, ENG examination
showed slowpursuitmovements in 72%of patients, slow-
ing of saccadic eye movements in 28%, abnormal opto-
kinetic nystagmus test results in 44%, and canal paresis
or caloric areflexia in 56% of cases. Compared with the
nonleukoaraiosis group, 50%, 17%, 44%, and 61%of cases
exhibited nonsignificant differences in slowpursuitmove-
ments, slowing of saccadic eyemovements, abnormal op-
tokinetic nystagmus test results, and abnormal caloric test
results, respectively. However, saccadic oscillation had
an occurrence rate of 72% in the leukoaraiosis group in
contrast with a 22% rate in the nonleukoaraiosis group,
revealing a significant statistical difference.
Conclusions: Saccadic oscillations in the ENG examina-
tion indicated leukoaraiosis on the magnetic resonance
imaging scan, with a sensitivity of 72% and a specificity of
78%. We therefore recommend using ENG examination
to screen elderly individuals with leukoaraiosis.
Arch Otolaryngol Head Neck Surg. 2007;133:245-249
mology and Hippocratic
usage, leukoaraiosis is de-
fined as a diminution of
density in the white mat-
ter, related to a specific type of cerebral is-