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Vol. 138 No. 3, March 1984
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Cefaclor v Amoxicillin in Treatment of Acute Otitis Media
G. Scott Giebink, MD ; Paul B. Batalden, MD; Joyce N. Russ, RN; Chap T. Le, PhD
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G. Scott Giebink, MD ; Paul B. Batalden, MD; Joyce N. Russ, RN; Chap T. Le, PhD
Am J Dis Child. 1984;138(3):287-292.
Abstract
• A randomized clinical trial compared cefaclor and amoxicillin for the treatment of acute otitis media (AOM).
Twenty-four (77%) of the 31 examinable patients treated with cefaclor and 25 (83%) of the 30 examinable
patients treated with amoxicillin had resolution of signs and symptoms after completing a ten- to 14-day
course of the antibiotic. Patients who had bilateral AOM, serous or mucold middle ear effusion, Hemophilus
influenzae cultured from effusion, or more than five previous otitis media episodes, or who were 3 years of
age or younger were more likely to fail treatment. Hemophilus influenzae isolated from effusion were
significantly less susceptible to cefaclor than amoxicillin, but none of the 12 treatment failures were caused
by antibiotic-resistant infections. Eight (36%) of the 22 patients who recovered after treatment and were
by antibiotic-resistant infectio