OBJECTIVE: to evaluate date on the demographic feature of patients diagnosed to have
aplastic anemia at Liaquat University of Medical and health Sciences Hyderabad /
Jamshore, from March 207 to August 2008.
STUDY DESIGN, PLACE AND DURATION: Descriptive observational study, Medical
Units of Liaquat University Hospital Hyderabad / Jamshoro, form March 2007 to August
PATIENTS AND METHODS: Out of 200 subjects 50 were diagnose with demographic
features of aplastic anemia. The diagnosis of aplstic anemia was done by.history and
clinical examination, complete blood count, reticulocyte count and confirmed by bone
marrow trephine. All those patients who had aplastic anemia based on bone marrow
trephine and patients of age?15 years both male and female were included and those who
were less then 15 years old and in whom diagnoses was not confirmed by bone marrow
RESULT: In our study out of these 50 subjects 25(50%) were diagnosed as severe
aplastice anemia, 10(20%) patients had very severe aplastic anemia, 05(10%) had non-
severe aplastic anemia, 05(10%) were associated with hepatitis C aplastic anemia and
remaining 05(10%) were of other type of aplastic anemia.
CONCLUSION: Aplastic anemia is a commonly seen more in males as compared to
females and severe aplastic anemia is most common among both male and females.
Aplastic anemia is the important cause of morbidity and the mortality and is also
associated with hepatitis.
KEY WORDS: Aplastic anemia, International Agranulocytosis and Aplastic Anemia
Study, Bone marrow.
Aplastic Anemia (AA) is defined as pancytopenia accompanied by a hypocellular bone
marrow1. Laboratory and clinical observations have implicated an immunologic path
physiology. As with other autoimmune diseases, both environmental triggers and indi-
vidual host factors are hypothesized to determine risk. AA has long been linked to
exposure to benzene, pesticides, and other chemicals2. Marrow failure is a severe
idiosyncratic complication of the use of certain medical