FIRST AMENDMENT TO BUILD-TO-SUIT LEASE
This First Amendment to Build-to-Suit Lease (" First Amendment ") is made and entered into as of March 29,
2000, by and between BRITANNIA POINTE GRAND LIMITED PARTNERSHIP, a Delaware limited
partnership (" Landlord "), and EXELIXIS, INC. (formerly known as Exelixis Pharmaceuticals, Inc.), a Delaware
corporation (" Tenant "), with reference to the following facts:
A. Landlord and Tenant are parties to a Build-to-Suit Lease dated as of May 12, 1999 (the " Lease ") covering,
among other things, a building presently under construction (" Building 1 ") on certain property owned by
Landlord (the " Phase 1 Property ") on Harbor Way in the City of South San Francisco, County of San Mateo,
State of California. The Lease also includes various options and rights on the part of Tenant to have a second
building constructed by Landlord, subject to certain conditions set forth in the Lease, on either the Phase 2-A
Property or the Phase 2-B Property as defined in the Lease. Terms used in this First Amendment as defined
terms but not defined herein shall have the meanings assigned to such terms in the Lease.
B. By letter dated September 27, 1999, Landlord (through its counsel) gave Tenant a Phase 2-B Acquisition
Notice under Section 1.1(c)(iii) of the Lease, notifying Tenant that Landlord had Acquired the Phase 2-B
Property. By letter dated December 20, 1999, Tenant exercised its option under Section 1.1(c) of the Lease to
have a building constructed on the Phase 2-B Property and leased to Tenant, subject to the parties entering into a
mutually acceptable lease agreement.
C. Landlord and Tenant have now reached mutual agreement on the terms and conditions to be applicable to the
construction, leasing and occupancy of a new building to be constructed on the Phase 2-B Property and, in
compliance with Section 1.1(c)(iii)(A) of the Lease, are entering into this First Amendment to set forth such terms
and conditions in a written lease amendment.
NOW, THEREFORE, in relian