THIRD AMENDMENT TO SUBLEASE
THIS THIRD AMENDMENT TO SUBLEASE (“ Amendment ”) is made as of the 17th day of April, 2009 (the “Effective
Date”), by and between INFINITY DISCOVERY, INC., a Delaware corporation formerly known as Infinity Pharmaceuticals, Inc.
(“ Sublandlord ”), and HYDRA BIOSCIENCES, INC. , a Delaware corporation (“ Subtenant ”).
WHEREAS, Sublandlord and Subtenant are parties to that certain Sublease dated August 24, 2004, as amended by that
certain First Amendment to Sublease dated as of October 17, 2005, as further amended by that certain Second Amendment to
Sublease dated as of January 9, 2006, and as affected by those certain letter agreements dated as of April 19, 2007, February 12,
2008 and March 13, 2009 (as amended and affected, the “ Sublease ”) pursuant to which Subtenant subleases from Sublandlord
certain premises containing approximately 16,167 rentable square feet of space (the “ Subleased Premises ”) located on the third
(3 rd ) floor of the building located at 790 Memorial Drive, Cambridge, Massachusetts, all as more particularly described in the
WHEREAS, Sublandlord and Subtenant have agreed to reduce the Subleased Premises on the terms and conditions set
forth herein, subject to the condition precedent of Sublandlord’s obtaining Prime Landlord’s written consent hereto.
NOW THEREFORE, for good and valuable consideration, and in consideration of the covenants and agreements herein
contained, the receipt and sufficiency of which are hereby acknowledged, the parties hereto hereby agree as follows:
1. Defined Terms . Capitalized terms not defined herein shall have the meanings ascribed to them in the Sublease.
2. Reduction of Subleased Premises . Effective as of the Effective Date, the Subleased Premises is hereby reduced by 3,008
rentable square feet by the elimination of that area shaded and identified as the “Infinity Space” on the floor plan attached
hereto as Exhibit A (the “ Surrendered Premises ”) and the Sublease h