Background Aim Loneliness due to social isolation is a source of psychological stress in adults. This study evaluated the impact of social Isolation on serum sodium and cortisol level in male wistar ratsMethods Sixteen male wistar rats were randomly divided into two groups n = 8 , Group 1 served as control. And were socially housed. Group 2 consisted of eight individually caged Wistar rats. The animals had access to food and water ad libitum and their level of physical activity was observed. After six weeks of Isolation, blood was collected from the animals via ocular puncture for Serum Cortisol and Sodium ion analysis, all data was analysed using SPSS software version 25.0. Values were considered significant at P 0.05.Results Results showed significant increase in the mean cortisol 33.82 ± 1.17 , decrease in mean sodium ion 113.875 ± 5.24 and negative correlation between sodium and cortisol.Conclusion The results from this study have shown that social isolation is a source of psychological stress which leads to depression and hyponatraemia. Uzoma Reichmann Iheanyi | Ufearo Chibueze Steven | Njoku-Oji Nancy Njideka | Okonkwo Chukwudi Onyeka | Muorah Chinecherem Onyekachi | Umeasiegbu Adaobi Chidinma "Impact of Social Isolation on Serum Sodium and Cortisol Level in male Wistar Rats" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5 , August 2021, URL: https://www.ijtsrd.com/papers/ijtsrd46294.pdf Paper URL: https://www.ijtsrd.com/medicine/physiology/46294/impact-of-social-isolation-on-serum-sodium-and-cortisol-level-in-male-wistar-rats/uzoma-reichmann-iheanyi
International Journal of Trend in Scientific Research and Development (IJTSRD)
Volume 5 Issue 5, July-August 2021 Available Online: www.ijtsrd.com e-ISSN: 2456 – 6470
@ IJTSRD | Unique Paper ID – IJTSRD46294 | Volume – 5 | Issue – 5 | Jul-Aug 2021
Page 2044
Impact of Social Isolation on Serum Sodium
and Cortisol Level in Male Wistar Rats
Uzoma Reichmann Iheanyi, Ufearo Chibueze Steven, Njoku-Oji Nancy Njideka,
Okonkwo Chukwudi Onyeka, Muorah Chinecherem Onyekachi, Umeasiegbu Adaobi Chidinma
Department of Human Physiology, Faculty of Basic Medical Sciences, Nnamdi Azikiwe University, Nnewi, Nigeria
ABSTRACT
Background/Aim: Loneliness due to social isolation is a source of
psychological stress in adults. This study evaluated the impact of
social Isolation on serum sodium and cortisol level in male wistar rats
Methods: Sixteen male wistar rats were randomly divided into two
groups (n = 8), Group 1 served as control. And were socially housed.
Group 2; consisted of eight individually caged Wistar rats. The
animals had access to food and water ad libitum and their level of
physical activity was observed. After six weeks of Isolation, blood
was collected from the animals via ocular puncture for Serum
Cortisol and Sodium ion analysis, all data was analysed using SPSS
software version 25.0. Values were considered significant at P <
0.05.
Results: Results showed significant increase in the mean cortisol
(33.82 ± 1.17), decrease in mean sodium ion (113.875 ± 5.24) and
negative correlation between sodium and cortisol.
Conclusion: The results from this study have shown that social
isolation is a source of psychological stress which leads to depression
and hyponatraemia.
KEYWORDS: Social Isolation, Stress, Sodium, Cortisol
How to cite this paper: Uzoma
Reichmann Iheanyi | Ufearo Chibueze
Steven | Njoku-Oji Nancy Njideka |
Okonkwo Chukwudi Onyeka | Muorah
Chinecherem Onyekachi | Umeasiegbu
Adaobi Chidinma "Impact of Social
Isolation on Serum Sodium and Cortisol
Level in