Treatment of Inflammatory Facial Acne Vulgaris with the
1450-nm Diode Laser: A Pilot Study
PAUL M. FRIEDMAN, MD,nw MING H. JIH, MD, PHD,n ARASH KIMYAI-ASADI, MD,n AND
LEONARD H. GOLDBERG, MDnz
nDermSurgery Associates, wUniversity of Texas Houston School of Medicine, and zMD Anderson Cancer Center,
BACKGROUND. The 1450-nm diode laser has been found to
damage sebaceous glands selectively and to be effective for the
treatment of inflammatory acne on the back.
OBJECTIVE. To evaluate the efficacy and safety of the 1450-nm
diode laser in the treatment of inflammatory facial acne
METHODS. Nineteen patients with inflammatory facial acne
were treated with the 1450-nm diode laser at 4- to 6-week
intervals. There was no control group. Clinical photographs
and lesion counts were obtained at baseline and after each
treatment. Subjective evaluation of response to treatment and
pain was assessed using a questionnaire.
RESULTS. All patients had a reduction in acne lesions. Lesion
counts decreased 37% after one treatment (po0.01), 58% after
two treatments (po0.01), and 83% after three treatments
(po0.01). Treatment-related pain was well tolerated, and
adverse effects were limited to transient erythema and edema
at treatment sites.
CONCLUSION. This is the first published report documenting the
safety and efficacy of laser treatment for inflammatory facial
acne. In our study, clinical improvement was seen in all patients
and was generally dramatic, even in those refractory to previous
treatment with oral isotretinoin. Topical anesthetics should be
used to minimize pain associated with treatment.
P. M. FRIEDMAN, MD, M. H. JIH, MD, PHD, A. KIMYAI-ASADI, MD, AND L. H. GOLDBERG, MD HAVE INDICATED NO
SIGNIFICANT INTEREST WITH COMMERCIAL SUPPORTERS.
ACNE VULGARIS is estimated to afflict between 40-
and 50-million people in the United States, with up to
34% of men and 27% of women between the ages of
15 and 44 having active acne lesions at any given
time.1 Although acne is often thought of as a minor