HANA BIOSCIENCES, INC.
Amendment to Stock Option Agreements
This Amendment to Stock Option Agreements (this “ Amendment ”) is made and entered into as of the
30th day of June, 2006, between Mark J. Ahn (“ Optionee ”) and Hana Biosciences, Inc., a Delaware
corporation (the “ Company ”).
A. Optionee and the Company entered into several Stock Option Agreements dated as of
November 1, 2003, February 15, 2004, February 26, 2004, and July 20, 2004, respectively (individually a “
Stock Option Agreement ” and collectively the “ Stock Option Agreements ”).
B. Pursuant to the Stock Option Agreements, the Company granted Optionee options to purchase
an aggregate of 952,305 shares of the Company’s common stock, as adjusted to reflect stock splits,
combinations, mergers and other adjustments prior to the date hereof.
C. The applicable exercise price relating to each Stock Option Agreement was less than the fair
market value of the Company’s common stock on the respective dates of the Stock Option Agreements.
D. On May 9, 2006, Optionee exercised his option to purchase shares of Company common stock
under the November 1, 2003 Stock Option Agreement in the amount of 164,508 shares, leaving a total of
787,797 shares available for exercise under the Stock Option Agreements.
E. Due to the tax implications of Section 409A of the Internal Revenue Code of 1986, as amended,
the Company and Optionee have agreed to amend the Stock Option Agreements in order to increase the
exercise prices to equal the fair market value of the Company’s common stock as of the date of each such
F. To compensate the Optionee for increasing the exercise prices, the Company has issued to
Optionee 74,887 shares of restricted common stock, subject to the terms set forth in that certain Restricted
Stock Agreement by and between the Company and Optionee dated of even date herewith.
G. Optionee and the Compa