Stem Cells in Predictive Toxicology
CIRM Workshop Report
July 7-8, 2008
CIRM WORKSHOP SUMMARY
2
Table of Contents
1. EXECUTIVE SUMMARY……………………………………………………………………………. 4
2. INTRODUCTION……………………………………………………………………………………... 7
3. STEM CELLS AND PREDICTIVE TOXICOLOGY IN DRUG DISCOVERY AND
DEVELOPMENT……………………………………………………………………………………….10
3.1 Deficiencies of Existing Models……………………………………………………………….. 10
3.2 Current Uses of Stem Cells in Drug Research, Discovery and Development…………………. 11
3.3 Key Areas of Interest………………………………………………………………………….. 12
3.3.1 Predictive Hepatotoxicity and Cardiotoxicity……………………………….………. 12
3.3.2 Predictive Neurotoxicity……………………………………………………………... 13
3.3.3 Predictive Developmental Toxicity…………………………………………………. 13
3.3.4 Toxicity and Individual Susceptibility……………………………………………….. 14
3.4 Technological Requirements for Implementation and Expansion…………………………….. 14
3.4.1 General Technological Needs……………………………………………………….. 14
3.4.2 Specialized Technological Needs …………………………………………………… 14
4. STEM CELLS AND PREDICTIVE TOXICOLOGY IN ENVIRONMENTAL
HEALTH ASSESSMENT…………………………………………………………………………….. 17
4.1 Deficiencies of Existing Models………………………………………………………………. 17
4.2 Developing Predictive Methods for Environmental Health Assessment……………………… 17
4.3 Biomonitoring and Human Surveillance………………………………………………………..18
4.4 Stem Cells and Environmental Health Assessment……………………………………………..19
4.4.1 Replacing or Enhancing Current in vitro Models……………………………………..19
4.4.2 iPS Cells ………………………………………………………………………………19
4.4.3 Reproductive and Developmental Toxicity…………………………………………....20
4.4.4 Genotoxicity, Carcinogenesis and Immunotoxicity……………………………………20
4.4.5 Organ Toxicity…………………………………………………………………………20
5. TECHNOLOGICAL ADVANCES IMPACTING STEM CELL USE
AND IMPLEMENTATION…………………………………………………………………………… 21
5.1 Technologies that Address Culturing and Growth Bottlenecks…………………………….….. 21
5.2 Co