Glucose homeostasis is strongly regulated to meet the strength needs of major organs and to maintain human health. The liver has a major role in control glucose homeostasis by controlling numerous pathways of glucose metabolism, over eating collection of glycogen union glycogenesis, separate glycogen of glycogenolysis, glucose separate of glycolysis, and under fasting condition amino corrosive into glucose are gluconeogenesis. this metabolic cycle reliant upon admission of food manage eating social huge of our life. Doesnt control influences diabetic, fat, liver sickness and so forth. accumulate facts from hereditary mammal models indicates that the brain, mostly the hypothalamus, has a key major in the homeostatic rule of might and glucose metabolism. Insulin is the activation of glycogen synthase by phosphorylation of the enzyme glucose 6 phosphate ratio. Glycogen is encoded by glycogen synthase, GS1 is expressed in muscle and other tissues, and GS2 is often expressed in the liver, although we have found that GS2 is rarely stored in the brain. We focused liver Glycogen synthase is regulated without delay by glycogen synthase kinase three, AMPK, protein kinase A PKA and casein kinase 2, each protein kinase resulting in a phosphorylated and catalytically inactive glycogen synthase. GS is also regulated by protein phosphatization, which energises glycogen synthase by dephosphorylation. We aimed previous studies on defects of glycogen metabolism. Tamilarasan Shanmugasundaram | Uthirakumar Devaraj | Elumalai Balamurugan "Irregularity of Glycogen Synthase Homeostasis Complications- Hepatic and Neuro Defects" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-6 , October 2021, URL: https://www.ijtsrd.com/papers/ijtsrd46479.pdf Paper URL : https://www.ijtsrd.com/biological-science/biochemistry/46479/irregularity-of-glycogen-synthase-homeostasis-complications-hepatic-and-neuro-defects/tamilarasan-shanmugasundaram
International Journal of Trend in Scientific Research and Development (IJTSRD)
Volume 5 Issue 6, September-October 2021 Available Online: www.ijtsrd.com e-ISSN: 2456 – 6470
@ IJTSRD | Unique Paper ID – IJTSRD46479 | Volume – 5 | Issue – 6 | Sep-Oct 2021
Page 749
Irregularity of Glycogen Synthase Homeostasis
Complications- Hepatic and Neuro Defects
Tamilarasan Shanmugasundaram, Uthirakumar Devaraj, Elumalai Balamurugan
Department of Biochemistry &Biotechnology, Faculty of Science
Annamalai University, Chidambaram, Tamil Nadu, India
ABSTRACT
Glucose homeostasis is strongly regulated to meet the strength needs
of major organs and to maintain human health. The liver has a major
role in control glucose homeostasis by controlling numerous
pathways of glucose metabolism, over eating collection of glycogen
union glycogenesis, separate glycogen of glycogenolysis, glucose
separate of glycolysis, and under fasting condition amino corrosive
into glucose are gluconeogenesis. this metabolic cycle reliant upon
admission of food manage eating social huge of our life. Doesn't
control influences diabetic, fat, liver sickness and so forth.
accumulate facts from hereditary mammal models indicates that the
brain, mostly the hypothalamus, has a key major in the homeostatic
rule of might and glucose metabolism. Insulin is the activation of
glycogen synthase by phosphorylation of the enzyme glucose-6-
phosphate -/+ ratio. Glycogen is encoded by glycogen synthase, GS1
is expressed in muscle and other tissues, and GS2 is often expressed
in the liver, although we have found that GS2 is rarely stored in the
brain. We focused liver Glycogen synthase is regulated without delay
by glycogen synthase kinase three, AMPK, protein kinase A (PKA)
and casein kinase 2, each protein kinase resulting in a phosphorylated
and catalytically inactive glycogen synthase. GS is also regulated by
protein phosphatization, which energises glycogen synthase by
dephosphorylation. We aimed previous studies on defects