AMENDMENT TO LEASE
MOULTON REALTY COMPANY
VIRUS RESEARCH INSTITUTE, INC.
The lease ("Lease") dated December 9, 1991 between Michael J. Spinelli, Trustee of M.R.C. Realty Trust;
Carol A. Hickey; Peter A. Spinelli, General Partner; and Spinelli Family Associates all doing business as Moulton
Realty Company, as Landlord and Lessor, and Virus Research Institute, Inc., as Tenant and Lessee, demising the
premises located at 61 Moulton Street, Cambridge, notice of which is recorded in the Middlesex South Registry
of Deeds in Book 21695, Page 407, is hereby amended as follows:
1. The number of parking spaces demised to Tenant for its exclusive use is to be increased from 30 spaces to 43
spaces, effective December 1,1996. The parking spaces demised to the Tenant effective December 1, 1996 are
shown on the new Schedule A annexed hereto, which the parties agree will substitute for the current Schedule A
to the Lease, effective December 1, 1996.
2. The parties acknowledge that Tenant has exercised validly and effectively its right and option to extend the
term of the Lease, as set forth in Article III(b) of the Lease, and that the term of the Lease now expires on
November 30, 2001; provided however, that the base rent due during the five (5) year period commencing on
December 1, 1996 to November 30, 2001 shall be $293,700.00 per year in monthly installments of $24,475.00.
3. Article III(b) of the Lease is amended to read as follows:
"OPTION The Landlord hereby grants to the Tenant and its successors and assigns the right and option to
extend the term of the Lease for a five-year period commencing on December 1, 2001 and ending an November
30, 2006, in accordance with the following terms and conditions:
If this Lease shall be in full force and effect at the expiration of the first extension term on November 30, 2001,
then the Tenant shall have the right to extend this Lease for an additional period of five (5) years, beginning on
December 1, 2001 and expir