Eur Respir J, 1995, 8, 472–473
Printed in UK - all rights reserved
Copyright ERS Journals Ltd 1995
European Respiratory Journal
ISSN 0903 - 1936
Association of histologically proven rheumatoid arthritis with
O. Menard*, N. Petit*, P. Gillet**, A. Gaucher**, Y. Martinet*+
Association of histologically proven rheumatoid arthritis with pulmonary sarcoidosis. O.
Menard, N. Petit, P. Gillet, A. Gaucher, Y. Martinet. ERS Journals Ltd 1995.
ABSTRACT: The association of rheumatoid arthritis proven by means of synovial
biopsy with pulmonary sarcoidosis proven by means of bronchial biopsy, occurred
in a 58 year old woman.
Corticosteroid therapy resulted in complete resolution of sarcoidosis but only
slight improvement of the rheumatoid arthritis, which was secondarily treated with
methotrexate with a successful outcome. Only two similar cases have been reported
with simultaneous histological proofs of both diseases.
Eur Respir J., 1995, 8, 472–473.
*Clinique Pneumologique Médico-Chirur-
gicale, and **Service de Rhumatologie A,
Hôpital de Brabois, Vandoeuvre-les-Nancy,
France. +INSERM U14, Vandoeuvre-les-
Correspondence: O. Menard, Clinique
Pneumologique Médico-Chirurgicale, CHU
Nancy, 54511 Vandoeuvre-les-Nancy, France
Keywords: Interstitial lung diseases, pul-
monary sarcoidosis, rheumatoid arthritis
Received: April 25 1994
Accepted after revision October 26 1994
Pulmonary involvement is common in rheumatoid
arthritis, and includes pleural effusion, pulmonary
intraparenchymal rheumatoid nodules, bronchiolitis and/
or interstitial lung disease with restrictive ventilatory
impairment. Furthermore, treatment of rheumatoid arth-
ritis with gold salts, D-penicillamine or methotrexate can
induce iatrogenic pulmonary interstitial diseases . On
the other hand, osteoarticular involvement by sarcoid-
osis is rare, but can mimic rheumatoid arthritis disease
in some acute or chronic polyarthritic forms . Differen-
tial diagnosis is sometimes diffi