The author(s) shown below used Federal funds provided by the U.S.
Department of Justice and prepared the following final report:
Assessment and In Vitro Repair of Damaged
This report has not been published by the U.S. Department of Justice.
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Opinions or points of view expressed are those
of the author(s) and do not necessarily reflect
the official position or policies of the U.S.
Department of Justice.
National Institute of Justice
Forensic DNA Research and Development
Award # 2002-IJ-CX-K001
Assessment and In Vitro Repair of Damaged DNA Templates
Jack Ballantyne, PhD
Department of Chemistry
Associate Director for Research
National Center for Forensic Science
4000 Central Florida Blvd, Bldg #5
University of Central Florida
Orlando, FL 32816-2366
Phone: (407) 823 4440
Fax: (407) 823 2252
This document is a research report submitted to the U.S. Department of Justice. This report has not
been published by the Department. Opinions or points of view expressed are those of the author(s)
and do not necessarily reflect the official position or policies of the U.S. Department of Justice.
DNA extracted from biological stains is often intractable to analysis. This may
due to a number of factors including a low copy number (LCN) of starting molecules, the
presence of soluble inhibitors or damaged DNA templates. Remedies may be available to
the forensic scientist to deal with LCN templates and soluble inhibitors but none
presently exist for damaged DNA. In fact, only recently has the biochemical nature, the
extent of DNA dama