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Home > Products > Organocatalysts > Asymmetric Organocatalysts > Chiral Imidazolidinones
Imidazolidinone, an organic compound with a molecular formula of C H N O, is a colorless needle crystal, which
is generally divided into 2-imidazolidinone and 4-imidazolidinone. As an important member of the imidazole
series of compounds, imidazolidinone has attracted more and more attention because of its wide application in
the fields of medicine, chemical industry, and biology.
Figure 1. 2-imidazolidinone
Imidazolidinones can be used in a variety of catalytic reactions, of which the most common is Diels-Alder
reactions, such as the asymmetric Diels-Alder reaction of cyclopentadiene with cinnamaldehyde. It can also be
used for asymmetric cycloaddition, asymmetric alkylation, and the like.
Ammonium carbonate method: Some scholars have carefully studied the results of predecessors, and
proposed a method for synthesizing imidazolidinone with ethylene carbonate as raw material and ethylene
glycol, ethylenediamine and ethylene oxide. It should be noted that in this method, the raw material
ammonium carbonate is so unstable that it can be easily decomposed in the air.
Figure 2. Synthesis of imidazolidinone from ethylene carbonate and ethylenediamine.
Carbon dioxide method: Some scholars have used carbon dioxide and diamine or amino alcohol
compounds to synthesize ring veins. In the absence of a catalyst, the authors reacted with ethylenediamine
and carbon dioxide at 7 MPa and 100℃ to obtainimidazolidinone in 97% yield.
Figure 3. Synthesis of imidazolidinone from dioxide and ethylene