Oyster mushroom Pleurotus ostreatus is belong to the group of healthy foods, as they contain high levels of proteins, vitamins and different classes of compounds, it is discovered that oyster mushrooms could play a key role in maintaining good health. Oyster mushroom Pleurotus sp. Class Basidiomycetes and Family Agaricaceae are widely known as ‘dhingri' in India. Pleurotus Ostreatus have several medicinal properties including , antitumor, immune modulatory, anti inflammatory, anticancer, antigenotoxic, anti arthritic, hypo cholesterolaemic, antihyperglycaemic, antioxidant, antihypertensive, antiplatelet aggregating, antiviral and antimicrobial activities.. In this paper studied that effects of chemical constituents of oyster mushroom Pleurotus sp. on DNA damaging protein which analyzed its activity of PARP inhibiting or vice - versa.For this analysis we choose the molecular docking technique to check the effects of different chemical constituents of oyster mushroom Pleurotus sp. on DNA damaging protein and compare their results to PARP inhibitory drugs which taken as standard. We perform the molecular docking in between chemical constituents of oyster mushroom Pleurotus sp. and 4UND protein compare to performance of molecular docking in between standard PARP inhibitory drugs and 4UND protein with the help of PyRx and BIOVIA Discovery studio software.The analysis of molecular docking shows that some chemical constituents of oyster mushroom Pleurotus sp. having more binding affinity than standard PARP inhibitory drugs. The Rutin shows better binding affinity than PARP inhibitory drugs on the same protein. Kajal S. Nadaf | Dr. Pravin Badhe "In-silico Study of Oyster Mushroom (Pleurotus Ostreatus) Targeting PARP Protein (4UND)" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-6 , October 2021, URL: https://www.ijtsrd.com/papers/ijtsrd47680.pdf Paper URL : https://www.ijtsrd.com/pharmacy/other/47680/insilico-study-of-oyster-mushroom--pleurotus-ostreatus-targeting-parp-protein-4und/kajal-s-nadaf
International Journal of Trend in Scientific Research and Development (IJTSRD)
Volume 5 Issue 6, September-October 2021 Available Online: www.ijtsrd.com e-ISSN: 2456 – 6470
@ IJTSRD | Unique Paper ID – IJTSRD47680 | Volume – 5 | Issue – 6 | Sep-Oct 2021
Page 1495
In-silico Study of Oyster Mushroom
(Pleurotus Ostreatus) Targeting PARP Protein (4UND)
Kajal S. Nadaf
1
, Dr. Pravin Badhe
2
1Student, Department of Pharmacy, 2Associate Professor, Pharmaceutics Department,
1,2Navasahyadri Institute of Pharmacy, Pune, Maharashtra, India
ABSTRACT
Oyster mushroom (Pleurotus ostreatus) is belong to the group of
healthy foods, as they contain high levels of proteins, vitamins and
different classes of compounds, it is discovered that oyster mushrooms
could play a key role in maintaining good health. Oyster mushroom
(Pleurotus sp.) Class Basidiomycetes and Family Agaricaceae are
widely known as ‘dhingri’ in India. Pleurotus Ostreatus have several
medicinal properties including;, antitumor, immune modulatory, anti-
inflammatory, anticancer, antigenotoxic, anti-arthritic, hypo-
cholesterolaemic, antihyperglycaemic, antioxidant, antihypertensive,
antiplatelet aggregating, antiviral and antimicrobial activities.. In this
paper studied that effects of chemical constituents of oyster mushroom
(Pleurotus sp.) on DNA damaging protein which analyzed its activity
of PARP inhibiting or vice – versa.
For this analysis we choose the molecular docking technique to check
the effects of different chemical constituents of oyster mushroom
(Pleurotus sp.) on DNA damaging protein and compare their results to
PARP inhibitory drugs which taken as standard. We perform the
molecular docking in between chemical constituents of oyster
mushroom (Pleurotus sp.) and 4UND protein compare to performance
of molecular docking in between standard PARP inhibitory drugs and
4UND protein with the help of PyRx and BIOVIA Discovery studio
software.
The analysis of molecular docking shows that some chemical
consti