Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the
Securities and Exchange Commission pursuant to Rule 24b-2 under the Securities Exchange Act of 1934, as amended, and 17
CFR §§200.80(b)(4) and 200.83.
SECOND AMENDMENT TO BIOPROCESSING SERVICES AGREEMENT
Diosynth RTP, Inc. Change Orders 9, 10, 10a, 11, 12 and 13
Diosynth RTP, Inc., f/k/a Covance Biotechnology Services Inc., having its principal place of business at 101 J. Morris
Commons Lane, Morrisville, North Carolina 27560 (“Diosynth” and “CBSI”) and Dendreon Corporation, having its principal
place of business at 3005 1 st Avenue, Seattle, Washington 98121 (“Dendreon” and “Sponsor”), make this Second Amendment
to that certain Bioprocessing Services Agreement dated March 16, 2001, as amended May 8, 2003, to which Diosynth and
Dendreon are parties (the “Agreement”). The effective date of this Second Amendment is October 29th, 2004.
Diosynth and Dendreon amend the Agreement as follows:
Pursuant to Section 27 of the Agreement, Diosynth and Dendreon have met and modified (“Modified”) the Agreement,
including the Scope, via Change Orders 9, 10, 10a, 11, 12 and 13.
The blocks of work in Change Orders 9, 10, 10a and 11 have been substantially completed, invoiced and paid.
Change Order 12, the “Validation Scope” and Change Order 13, the “Conformance Scope”, are each agreed
upon contemporaneously with the effective date of this Second Amendment.
Sub-section 1 m) is revised so that the Scope means the detailed Scope of Work attached to the Agreement as Appendix
One, as previously Modified by Change Orders 8, 9, 10, 10a, 11 and as Modified herein by Change Orders 12 and 13.
Change Orders 12 and 13 are delivered simultaneously with this Second Amendment.
Diosynth and Dendreon contemplate that one or both of Change Order 12 and Change Order 13 may be
Modified by agreement