tion F, similarly diluted, did not kill either organism
minutes. When diluted with three volumes of distilled water,
none of the antiseptics or solutions tested had any demonstrable
germicidal action even when the time of exposure of the organ¬
increased to fifteen minutes.
Tests were also made on
the ability of the solutions under
consideration to kill bacteria in fifteen seconds at a temperature
of 37 C.
The organisms used were B.
typhosus, B. coli,
Staphylococcus aureus, Streptococcus viridans and Streptococcus
hemolyticus. The results are given
in table 6.
tests. Solutions C and D showed no
tested unless small numbers of
moderately resistant organisms, such as
the streptococci, were
Even in this case
there is some doubt concerning
killing power because of the difficulty
teria in the ordinary broth medium. A more delicate medium
was therefore substituted so that
the tests did not correspond
exactly to those obtained with B. typhosus, B. coli and Staphylo¬
In all the tests,
the solutions were used with¬
out dilution. There was no apparent difference in the germicidal
action of Listerine, Liquor Antisepticus N. F., solution A,
solution E and solution F.
[End of Dr. Norton's report.]
These bactériologie results bear out
the pronouncement that
Torald Sollmann made many years ago when dealing with "The
Broader Aims of the Council on Pharmacy and Chemistry."
an article entitled "Some Studies
in Bottled Psychotherapy,"
Dr. Sollmann appraised the efficiency of Listerine thus :
fine antiseptic odor and
taste are possessed by thymol! After
the odor and taste of a saturated solution of
thymol with a
5 per cent solution of phenol, or a 1 per cent solution of corrosive sub¬
limate, could one doubt for a moment which is the most active? Evidently
not, for thymol, plus small quantities of boric and benzoic acid, under the
name of Listerine, sells at a dollar a bottle.