AMENDMENT NO. 1 TO MANUFACTURING AND SUPPLY AGREEMENT
This Amendment No. 1 to Manufacturing and Supply Agreement (“Amendment”) is made and entered into as of
June 30, 2010 (the “Effective Date of the Amendment”) by and between Alexza Pharmaceuticals, Inc., a
Delaware corporation having an address at 2091 Stierlin Court, Mountain View, CA 94043 (“Alexza”) and
Autoliv ASP, Inc., an Indiana corporation having an address at 3350 Airport Road, Ogden, Utah 84405
WHEREAS Alexza and Autoliv are parties to a Manufacturing and Supply Agreement dated November 2, 2007
WHEREAS the parties now wish to amend the Agreement;
NOW, THEREFORE, in consideration of the foregoing and the covenants and promises contained in this
Amendment and in accordance with and subject to the terms and conditions specified below, the parties agree as
Amendment of the Agreement
The parties hereby agree to amend the Agreement as of the Effective Date of the Amendment as provided below.
Capitalized terms used in this Amendment that are not otherwise defined herein shall have the meaning ascribed
to them in the Agreement.
[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and
filed separately with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities
Exchange Act of 1934, as amended.
1. Section 1.31 (“ Pilot Production Line ”) is hereby deleted and replaced with the following:
“‘Commercial Production Line’ means a production line for the commercial manufacture of the Chemical
Heat Packages, and all modifications thereof, which is located at Autoliv’s manufacturing site and is
comprised of two (2) cells, each of which has a nominal production capacity of [ * ] ([ * ]) Chemical
Heat Packages per year. If Autoliv does not achieve such output (i.e., each cell fabricated hereunder
shall have a nominal production capacity of [ * ] ([ * ]) Chemical Heat Packag