Product and Company Identification
SAFETY DATA SHEET
COSMEGEN®
1.
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Revision 25-Sep-2007
PRODUCT NAME:
COSMEGEN®
Label Name
Chemical Name
Not applicable.
Dactinomycin; Actinomycin-D; Meractinomycin
Synonyms
MERCK & CO., INC.
One Merck Drive
Whitehouse Station, NJ 08889-0100
(908) 423-1000
Emergency Telephone Number: 1-732-594-5555
Manufactured/Supplied by
Intended Use
Antineoplastic agent.
Material Product Number
3298; NDC # 0006-3298-22
Composition/Information on Ingredients
2.
Component
CAS Number
Percent (%)
DACTINOMYCIN
C62H86N12O16
1255.47
50-76-0
2.4
MANNITOL
C6H14O6
182.17
69-65-8
97.6
Molecular weight
EC Label
Molecular Formula
Exempt from the EU Dangerous Substances Directive.
Hazards Identification
3.
Appearance
Label Text
Do not get on skin or clothing. Do not get in eyes, on skin or on
clothing. Do not ingest. Avoid breathing dust. Keep container
closed. Use only with adequate ventilation. Avoid exposure during
pregnancy. Wash thoroughly after handling.
Sterile, yellow to orange lyophilized powder. When reconstituted,
COSMEGEN is a clear, gold-colored solution.
DANGER!
FINISHED PHARMACEUTICAL PRODUCT
CYTOTOXIC ANTINEOPLASTIC AGENT
HIGHLY TOXIC IF SWALLOWED OR INHALED. CAUSES
RESPIRATORY TRACT, MUCOUS MEMBRANE, EYE AND SKIN
BURNS.
CAUSES BONE MARROW SUPPRESSION.
CAN CAUSE BIRTH DEFECTS.
CAN CAUSE CANCER.
Potential Health Effects
See Section 11 for detailed information.
Emergency Overview
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COSMEGEN®
Product name
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Revision 25-Sep-2007
If swallowed, do not induce vomiting unless directed to do so by
medical personnel. Never give anything by mouth to an
unconscious person. Get medical attention immediately.
Skin Contact
In case of contact, immediately flush eyes with plenty of water for
at least 15 minutes. Get medical attention immediately.
In case of contact, immediately flush skin with plenty of water for at
least 15 minutes while removing contaminated clothing and shoes.
Contaminated clothing should be destroyed. Thoroughly clean
shoes before r