FIRST AMENDMENT TO LEASE
This FIRST AMENDMENT TO LEASE (this “Amendment” ) is made as of November 29, 2005 (the
“Effective Date” ) by and between DIV NEEDHAM 115 LLC, a Massachusetts limited liability company with an address of c/o
The Davis Companies, One Appleton Street, Boston, MA 02116 ( “Landlord” ) and AVANT IMMUNOTHERAPEUTICS, INC.,
a Delaware corporation, with an address of 119 Fourth Avenue, Needham, Massachusetts 02494 ( “Tenant” ).
A. Fourth Avenue Ventures Limited Partnership ( “Fourth Avenue Ventures” ), as landlord, and
T Cell Sciences, Inc. ( “T Cell” ) entered into that certain lease dated May 1, 1996, as amended by letter
agreement dated April 23, 2001 (collectively, the “Lease” ) of certain premises consisting of 54,317 rentable
square feet of space located on a portion of the first ( 1 st ) floor and a portion of the second (2 nd ) floor (the
“Original Premises” ) in the building located at and commonly known as 115-119 Fourth Avenue, Needham,
Massachusetts (the “Building” ).
B. Landlord is the successor in interest to Fourth Avenue Ventures.
C. Tenant is the successor in interest to T Cell.
D. The Lease Term commenced on May 1, 1996 and is currently scheduled to expire on April 30,
E. Landlord and Tenant wish to amend the Lease to (i) reduce the Original Premises to consist of
35,189 rentable square feet on the first (1 st ) floor of the Building as delineated on Exhibit A attached hereto
(the “Retained Premises” ) and terminate the Lease as to the remainder of the Original Premises effective as of
the Early Termination Date (as defined in Section 2 of this Amendment); (ii) set forth the obligations of Landlord
to perform and pay for the Base Building Work (as defined in Exhibit C attached hereto) and the respective
obligations of Landlord and Tenant to perform and pay for the Tenant Improvement Work (as defined in Exhibit
C attached hereto) to th