Research Article Biology and Medicine, Vol 1 (3): 15-19, 2009
Assessment of side-effects of administration of artemether in humans
1AS Adekunle*, 3CO Falade, 2EO Agbedana, 3A Egbe
1Department of Biochemistry, Ladoke Akintola University of Technology, Ogbomoso, Nigeria.
2Department of Pharmacology and Therapeutics, University of Ibadan, Nigeria.
3Department of Chemical Pathology, University of Ibadan, Nigeria.
*Corresponding author: firstname.lastname@example.org
P.O. Box 14066, U.I. Ibadan, Oyo State. Nigeria.
In animal in-vivo study, we have reported some significant changes such as reduced sperm counts, degeneration of
seminiferous epithelium and interstitial leydig cells in the testicle. Therefore human study was designed to assess the
effects of artemether on some biochemical parameters in individuals treated with artemether. Moderate and transient
side effects were observed after administration. This implies that administration of artemether is still tolerated and the
moderate side effects are not comparable with the debilitating effects of malaria infection it is meant to cure.
Artemisinine is still a tolerable antimalaria drug with no major side effects on human.
Keywords: Artemether, Antimalaria, Biochemical parameters, Side-effects, Humans.
Artemisinine is the most rapid-acting class of
antimalaria drugs for both uncomplicated and
severe malaria. They act against the asexual
stage gametocytes and they block sexual stage.
Artemisinine is a natural antimalaria drug
derived from the plant Artemisia annual. It is
in traditional Chinese drug for
management of fever resulting from malaria. To
improve its bioavailability, its derivatives such as
(methyl ether of
dihydroartemisinin) is derived from artemisinine
(Chinese plant Quinghaosu), and extract of the
herb artemisia annual L.