Neglected Burden of Human vivax Malaria:
Comparative Analysis of Plasmodium vivax and Key Related Species
Plasmodium Comparative Genomics Writing Group:
John Barnwell:
Malaria Research and Development Laboratories Unit, CDC
Jane Carlton:
Dept. Medical Parasitology, NYU School of Medicine
William Collins:
Division of Parasitic Diseases, CDC
Ananias Escalante:
School of Life Sciences, Arizona State University
Jim Mullikin:
Comparative Genomics Unit, NHGRI
Allan Saul:
Laboratory of Malaria and Vector Research, NIAID
August 13, 2007
This proposal represents the first of a trio of white papers which are being proposed by the
malaria and anopheline research communities to target specific areas of malaria research that will be
significantly enhanced through the availability of genome sequence data. This first paper proposes
sequencing isolates of Plasmodium vivax, the major cause of malaria outside Africa, and several related
monkey species which are used as robust and faithful model systems for the study of human malaria. The
second white paper is concerned with the generation of additional sequence data from Plasmodium
falciparum, the major cause of malaria in Africa, which will add to the list of strains that have already
been sequenced during the generation of a genetic diversity map. The third white paper addresses the
need for additional sequence data of the mosquito vector Anopheles, species of which transmit the
malaria parasite. All three papers are complimentary and represent a focused attempt to integrate of the
needs of the various scientific communities The Anolpheles white paper is nearing completion and
development of the P. falciparum white paper is well underway; both are anticipated to be
submitted this fall.
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Table of Contents
I. Executive Summary.................................................................................................................................3
II. Introduction a