December 16, 2008
13884 Catawba Circle
Athens, AL 35611
Attention: James P. English
Re: Amendment to Commercial Real Estate Lease
Reference is made to that Commercial Real Estate Lease (the “Lease”) entered into by and between Durect Corporation, a
Delaware corporation, (“LESSEE”) and EWE, Inc., an Alabama corporation dated September 21, 2004 (“LESSOR”). All
capitalized terms used herein shall have the meaning ascribed to such terms in the Lease.
LESSOR and LESSEE hereby agree as follows, effective on the date that both LESSOR and LESSEE have executed this
The term of the Lease set forth in Paragraph 3 shall be extended by one year such that the Lease shall terminate on
September 30, 2010 instead of September 30, 2009.
The rent payable during the period from October 1, 2009 to September 30, 2010 shall be the same rent as payable during
Year 5 as set forth in Paragraph 6 of the Lease.
Except as expressly modified above, all remaining terms of the Lease shall remain the same. LESSOR and LESSEE have
hereunto set or caused to be set their respective signatures and seals on this dates set forth herein.
/s/ James E. Brown
James E. Brown
AGREED TO BY EWE, INC.
/s/ James P. English
Title: Vice President