Does Placental Growth Factor Play a Role in The Etiopathogenesis of Psoriasis?
Hanan M Saleh*, Nehal M Zu Elfakkar*, Mona G Al Husseny** and Nebal M Darweesh***
Egyptian Dermatology Online Journal 3 (1): 2, June 2007
* Departments of Dermatology*, Internal Medicine and Rehabilitation** and Microbiology and
Immunology***,Ain Sham University
Accepted for publication in May, 2007.
Objective: psoriasis is a chronic dermatosis characterized by the presence of heavy neutrophilic
infiltrate in both the dermis and epidermis, together with elongated tortuous blood vessels in dermal
papillae. Several factors are found to be behind such a type of inflammation, including PlGF.
Recognition of how this factor involved in the pathogenesis of psoriasis may be of great help in the
development of a new specific therapeutic modality of this disease.
Aim of the study: We aimed in this work to evaluate the role of PlGF as one of the factors
underlying the pathogenesis of psoriasis and psoriatic arthritis through induction of angiogenesis and
recruitment of the neutrophilic infiltrate and its correlation with disease severity.
Patients and methods: forty psoriatic patients were included in this study; examination and
determination of the disease severity using PASI score and disease duration were done. Measurement
of the serum PlGF level using ELISA technique was performed and correlation of disease severity and
duration with its level was also done.
Results: we found that PlGF was high in 92.5% of patients and was significantly high in those
with sever and moderate disease activity in comparison to those of mild activity and control group.
There was also insignificant difference in its serum level between the patients with mild disease
activity and control group. While, the correlation between the disease severity and its level was a
statistically significant positive correlation, the correlation between the disease duration and the serum
level of PlGF was insignificant. Conclusion: PlGF h