A COMPARATIVE STUDY OF SUBCUTANEOUS NODULES IN
RHEUMATIC FEVER AND RHEUMATOID ARTHRITIS*t
BY M. H. DAWSON, M.D.
(From the Department of Medicine of the College of Physicians and Surgeons,
Columbia University, and the Arthritis Clinic of the Presbyterian Hospital,~
PLATES 50 TO 55
(Received for publication, February 1, 1933)
Since the original observations of Meynet (1) and Barlow and
Warner (2) on the occurrence of subcutaneous nodules in rheumatic
fever, numerous studies on these lesions have appeared.
It is now well
recognized that subcutaneous nodules are a frequent manifestation of
the disease rheumatic fever and that these lesions present a highly
characteristic histological structure. Occasional reference (3) has also
been made to the presence of subcutaneous nodules in rheumatoid
arthritis but, until recent years, detailed pathological descriptions of
the lesions in this disease have not been presented.
In the last few
years, however, communications have appeared (4-7), which have
shown that subcutaneous nodules are of not infrequent occurrence in
rheumatoid arthritis and that these lesions also possess a highly char-
acteristic histological structure. These observations have led to a
comparative study of the nodules in the two diseases and to a con-
sideration of the relationship between the clinical entities, rheumatic
fever and rheumatoid arthritis (3).
In the present communication there is presented a detailed study
of the subcutaneous nodules in the two diseases. This study has
* This paper was presented in abstract before the twenty-third annual meeting
of the American Society for Clinical Investigation, Atlantic City, May, 1931.
t The term rheumatoid arthritis is used synonymously with the terms chronic
infectious and atrophic arthritis.
:~ The Arthritis Clinic of the Presbyterian Hospital is supported by the Faulkner
on December 1, 2009 jem.rupress.orgDownloaded from
Published May 1, 1933
RHEUMATIC FEVER AND RHEUMATOID ARTHRITI