Arnold, L. L. Barnes and J. L. Bienias
D. A. Bennett, R. S. Wilson, J. A. Schneider, D. A. Evans, C. F. Mendes de Leon, S. E.
Education modifies the relation of AD pathology to level of cognitive function in
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CME Education modifies the relation of
AD pathology to level of cognitive
function in older persons
D.A. Bennett, MD; R.S. Wilson, PhD; J.A. Schneider, MD; D.A. Evans, MD; C.F. Mendes de Leon, PhD;
S.E. Arnold, MD; L.L. Barnes, PhD; and J.L. Bienias, ScD
Abstract—Objective: To test the hypothesis that years of formal education modifies the relation of AD pathology to level
of cognitive function. Methods: A total of 130 older Catholic clergy participating in the Religious Orders Study underwent
annual cognitive function testing and brain autopsy at the time of death. Individual cognitive function tests were z-scored
and averaged to yield a global measure of cognitive function and summary measures of five different cognitive abilities.
Neuritic and diffuse plaques and neurofibrillary tangles were counted in separate 1 mm2 areas of maximal density.
Counts were converted to standard scores by dividing by their SD, and combined to yield a global AD pathology score and
summary scores of each postmortem index. Linear regression was used to examine the relation of education and AD
pathology scores to level of cognitive function proximate to death, controlling for age and sex. Subsequent analyses tested
the interaction between