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Innovations in Pharmaceuticals and Pharmacotherapy
Gastro-retentive drug delivery systems offer the advantage in prolonging the gastric emptying time for
drugs having a narrow absorption window in the gastrointestinal tract (GIT) resulting in poor
absorption. Ciprofloxacin and metronidazole both have a short half-life resulting in increase in dosage
regimen. Metronidazole is a nitro imidazole antibiotic and is ineffective on aerobic bacteria.
Ciprofloxacin on the other hand is a broad spectrum ﬂuoroquinolone antibacterial agent, the
combination of both, is active against a broad spectrum of obligate anaerobic bacteria. The purpose of
this study was to design, optimize and evaluate gastro- retentive floating tablet of Metronidazole and
Ciprofloxacin hydrochloride combination to increase the residence time in the stomach and thereby
giving prolong action of each drug individually. Screening of the various grades of HPMC polymer for
optimization of matrix forming polymer, followed by optimization of the ratio of the polymer, and the
quantity of the swelling agent guar gum. The micromeritic properties, tablet evaluation properties,
floating behavior and drug release studies for ciprofloxacin and metronidazole were conducted as per
guidelines and compared to the marketed product dissolution profile. The tablets showed acceptable
physicochemical properties. The optimization showed that HPMC E10M and HPMC K100M in the ratio
of 1:2 were the best suited polymers for the matrix whereas guar gum at 3.3 % was the ideal
concentration for the desired floating and drug release profile. The optimized batch was subjected to
stability studies at 40 °C/75% RH for 3 months and depicted a stable formulation.
Key words: Ciprofloxacin, metronidazole, gastro-retentive drug delivery systems, matrix forming polymer.
*Corresponding author: Mr. Rohit Lowalekar, Bhupal Nobles Institute of Pharm